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Blocking the Spinal Fbxo3/CARM1/K+ Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief
Many epigenetic regulators are involved in pain-associated spinal plasticity. Coactivator-associated arginine methyltransferase 1 (CARM1), an...
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Anti-hyperalgesic and anti-inflammatory effects of 4R-tobacco cembranoid in a mouse model of inflammatory pain
4R is a tobacco cembranoid that binds to and modulates cholinergic receptors and exhibits neuroprotective and anti-inflammatory activity. Given the...
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Upregulation of Beta4 subunit of BKCa channels in the anterior cingulate cortex contributes to mechanical allodynia associated anxiety-like behaviors
The anterior cingulate cortex (ACC) serves as a critical hub for the anxiety and pain perception. The large-conductance Ca 2+ -activated potassium...
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Models of Diabetes in Rats: A Focus on Diabetic Neuropathy and Biomarkers
The increased prevalence of diabetic neuropathy (DN), as reported by World Health Organization, is seriously alarming. There is an unmet need to...
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Vincamine as an agonist of G-protein-coupled receptor 40 effectively ameliorates diabetic peripheral neuropathy in mice
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, which has yet no curable medication. Neuroinflammation and mitochondrial...
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LXR agonist improves peripheral neuropathy and modifies PNS immune cells in aged mice
BackgroundPeripheral neuropathy is a common and progressive disorder in the elderly that interferes with daily activities. It is of importance to...
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Clavulanic Acid Attenuating Effect on the Diabetic Neuropathic Pain in Rats
Diabetic neuropathy is one of the most common complications of diabetes mellitus. Excess glutamate release and oxidative stress are hypothesized to...
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Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors
With swee** advances in precision delivery systems and manipulation of the genomes and transcriptomes of various cell types, medical biotechnology...
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Astrocytes in Chronic Pain: Cellular and Molecular Mechanisms
Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-effects of therapies. Astrocytes are the most abundant...
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Role of Brain Derived Neurotrophic Factor and Related Therapeutic Strategies in Central Post-Stroke Pain
Brain-derived neurotrophic factor (BDNF) is vital for synaptic plasticity, cell persistence, and neuronal development in peripheral and central...
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The Role of ATP Receptors in Pain Signaling
Since new roles of nucleotides as neurotransmitters were proposed by Geoffrey Burnstock, the roles of ATP and P2 receptors (P2Rs) have been...
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Nanomedicine and voltage-gated sodium channel blockers in pain management: a game changer or a lost cause?
Pain, a complex and debilitating condition affecting millions globally, is a significant concern, especially in the context of post-operative...
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Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial
BackgroundInduction of long-term synaptic depression (LTD) is proposed as a treatment mechanism for chronic pain but remains untested in clinical...
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Excitatory and inhibitory neuronal signaling in inflammatory and diabetic neuropathic pain
Pain, although unpleasant, is an essential warning mechanism against injury and damage of the organism. An intricate network of specialised sensors...
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Expression of Human Immunodeficiency Virus Transactivator of Transcription (HIV-Tat1-86) Protein Alters Nociceptive Processing that is Sensitive to Anti-Oxidant and Anti-Inflammatory Interventions
AbstractDespite the success of combined antiretroviral therapy (cART) in reducing viral load, a substantial portion of Human Immunodeficiency Virus...
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2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors
Neuropathic pain (NP) remains an untreatable disease due to the complex pathophysiology that involves the whole pain neuraxis including the...
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Contribution of P2X4 receptor in pain associated with rheumatoid arthritis: a review
Pain is the most common symptom reported by patients with rheumatoid arthritis (RA) even after the resolution of chronic joint inflammation. It is...
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Modulatory Processes in Craniofacial Pain States
Pain is a common symptom associated with many disorders affecting the craniofacial tissues that include the teeth and their supporting structures,...
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Interleukin-6: evolving role in the management of neuropathic pain in neuroimmunological disorders
BackgroundNeuropathic pain in neuroimmunological disorders refers to pain caused by a lesion or disease of the somatosensory system such as multiple...
