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Chronic stress impairs the aquaporin-4-mediated glymphatic transport through glucocorticoid signaling
BackgroundThe glymphatic system has recently been proposed to function as a brain-wide macroscopic system for the clearance of potentially harmful...
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Myelination is delayed during postnatal brain development in the mdx mouse model of Duchenne muscular dystrophy
BackgroundIn Duchenne muscular dystrophy (DMD), the loss of the dystrophin component of the dystrophin-glycoprotein complex (DGC) compromises plasma...
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Long and Short QT Syndromes
The long and short QT syndromes are genetically transmitted arrhythmogenic diseases characterized by an abnormal QTc on the basal ECG and by an...
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Progress of Genomics in Cardiac Conduction and Rhythm Disorders
Genes and genetic loci linked thus far to cardiac electrical function and arrhythmia have been primarily uncovered through numerous studies. The...
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Tumor analysis: freeze–thawing cycle of triple-negative breast cancer cells alters tumor CD24/CD44 profiles and the percentage of tumor-infiltrating immune cells
ObjectiveThe use of novel methods to characterize living tumor cells relies on well-conceived biobanks. Herein, we raised the question of whether the...
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Genetic Testing for Inheritable Cardiac Channelopathies
Inheritable cardiac channelopathies (ICC) are defined as primary electrical disorders without identifiable cardiac structural abnormalities and are...
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The Cardiac Sodium Channel and Its Protein Partners
Activation of the electrical signal and its transmission as a depolarizing wave in the whole heart requires highly organized myocyte architecture and...
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Actin depolymerization mediated loss of SNTA1 phosphorylation and Rac1 activity has implications on ROS production, cell migration and apoptosis
Alpha-1-syntrophin (SNTA1) and Rac1 are part of a signaling pathway via the dystrophin glycoprotein complex (DGC). Both SNTA1 and Rac1 proteins are...
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Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury
Recently, there have been emerging interests in the area of microvesicles and exosome (MV/E) released from brain cells in relation to...
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A meta-analysis of public microarray data identifies biological regulatory networks in Parkinson’s disease
BackgroundParkinson’s disease (PD) is a long-term degenerative disease that is caused by environmental and genetic factors. The networks of genes and...
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Sarcoglycanopathies: Clinical, Molecular and Genetic Characteristics, Epidemiology, Diagnostics and Treatment Options
Sarcoglycanopathies are a group of autosomal recessive limb-girdle muscular dystrophies (LGMD) caused by mutations in sarcoglycan genes: SGCA (LGMD...
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GRMD cardiac and skeletal muscle metabolism gene profiles are distinct
BackgroundDuchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene, which codes for the dystrophin protein. While progress has been...
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Discovery and replication of a peripheral tissue DNA methylation biosignature to augment a suicide prediction model
BackgroundSuicide is the second leading cause of death among adolescents in the USA, and rates are rising. Methods to identify individuals at risk...
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A Novel Relationship for Schizophrenia, Bipolar, and Major Depressive Disorder. Part 8: a Hint from Chromosome 8 High Density Association Screen
Convergent evidence from genetics, symptomatology, and psychopharmacology implies that there are intrinsic connections between schizophrenia (SCZ),...
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Cardiac Arrhythmias Related to Sodium Channel Dysfunction
The voltage-gated cardiac sodium channel (Nav1.5) is a mega-complex comprised of a pore-forming α subunit and 4 ancillary β-subunits together with...
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Targeted Gene Resequencing (Astrochip) to Explore the Tripartite Synapse in Autism–Epilepsy Phenotype with Macrocephaly
The frequent co-occurrence of autism spectrum disorders (ASD) and epilepsy, or paroxysmal EEG abnormalities, defines a condition termed...
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Molecular Pathways and Animal Models of Cardiomyopathies
Cardiomyopathies are a heterogeneous group of disorders of heart muscle that ultimately result in congestive heart failure (CHF), sudden cardiac...
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