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Sudden Cardiac Death (SCD) – risk stratification and prediction with molecular biomarkers
Sudden cardiac death (SCD) is a sudden, unexpected death that is caused by the loss of heart function. While SCD affects many patients suffering from...
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Necroptosis, pyroptosis and apoptosis: an intricate game of cell death
Cell death is a fundamental physiological process in all living organisms. Its roles extend from embryonic development, organ maintenance, and aging...
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Sudden Cardiac Arrest in an Asymptomatic Zinc Phosphide-Poisoned Patient: A Case Report
Zinc phosphide is a gray to black powder mainly used as a rodenticide. In contact with gastric fluid, it releases phosphine which is the main toxic...
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The Genetics of Human Congenital Coronary Vascular Anomalies
The genetics of human congenital coronary vascular anomaliesCoronaryvascular anomalies (hCCVA) remains largely underresearched. This is surprising,...
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Opioids-Induced Long QT Syndrome: A Challenge to Cardiac Health
The challenge posed by opioid overdose has become a significant concern for health systems due to the complexities associated with drug prohibition,...
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Physiologic Measures in Diabetes: QTc Prolongation
Cardiovascular disease is the leading cause of mortality in diabetes, necessitating biomarkers beyond traditional methods to stratify risk in these...
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Human Genetics of Cardiac Arrhythmias
Inherited forms of cardiac arrhythmias mostly are rare diseases (prevalence <1:2000) and considered to be either “primary electrical heart disorders”...
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Clinical and Genetic Characteristics of Congenital Long QT Syndrome
AbstractLong QT syndrome is a rare ion channel cardiac disorder, the main manifestations of which are prolongation of the QT interval on the ECG and...
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The Role of Ion Channel in Epilepsy Including SUDEP Cases
Epilepsy is a central nervous system disorder characterized by recurrent seizures. Identification of seizures with excessive electrical activity can...
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The Role of Ion Channel in Epilepsy Including SUDEP Cases
Epilepsy is a central nervous system disorder characterized by recurrent seizures. Identification of seizures with excessive electrical activity can...
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Cell death in the human infant central nervous system and in sudden infant death syndrome (SIDS)
The brainstem has been a focus of sudden infant death syndrome (SIDS) research with amassing evidence of increased neuronal apoptosis. The present...
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Detection of a novel pathogenic variant in KCNH2 associated with long QT syndrome 2 using whole exome sequencing
BackgroundLong QT syndrome (LQTS) is a cardiac channelopathy characterized by impaired myocardial repolarization that predisposes to life-threatening...
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Acute Coxsackievirus B3-induced meningo-cerebellitis in an immunocompetent adult patient
We report an acute Coxsackievirus B3 (CVB3)-induced meningo-cerebellitis in an immunocompetent adult patient. CVB3 has a global distribution and is...
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Genome Editing and Inherited Cardiac Arrhythmias
Inherited arrhythmic disorders are a group of heterogeneous diseases predisposing to life-threatening arrhythmias and sudden cardiac death. Their...
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The Short QT Syndrome
The short QT syndrome (SQTS) is characterised by abbreviated QT intervals on the electrocardiogram and by an increased risk of atrial and ventricular...
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Impact of Prenatal Nicotine Exposure on Placental Function and Respiratory Neural Network Development
Smoking during pregnancy is associated with multiple undesirable outcomes in infants, such as low birth weight, increased neonatal morbidity and...
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Defects in Ankyrin-based Protein Targeting Pathways in Human Arrhythmia
Ion channels and transporters regulate transmembrane electrochemical gradients to control cardiomyocyte depolarization/repolarization and cell...
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Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology
The cardiac troponin T variations have often been used as an example of the application of clinical genoty** for prognostication and risk...
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Transporter Hypothesis in Pharmacoresistant Epilepsies: Is it at the Central or Peripheral Level?
The multidrug resistance (MDR) phenotype characterizes patients with refractory epilepsy (RE). Seizures are not controlled despite receiving various...
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Decision-making and experiences of preimplantation genetic diagnosis in inherited heart diseases: a qualitative study
Preimplantation genetic diagnosis (PGD) ensures a disease-causing variant is not passed to the next generation, including for inherited heart...
