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Electrophysiological aftereffects of high-frequency transcranial random noise stimulation (hf-tRNS): an EEG investigation
There is evidence that high-frequency transcranial random noise stimulation (hf-tRNS) is effective in improving behavioural performance in several...
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SPOCK1, as a potential prognostic and therapeutic biomarker for lung adenocarcinoma, is associated with epithelial-mesenchymal transition and immune evasion
BackgroundThe occurrence of epithelial-mesenchymal transition (EMT) and immune evasion is considered to contribute to poor prognosis in lung...
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Optimal reaching trajectories based on feedforward control
In human upper-arm reaching movements, the variance of the hand position increases until the middle of the movement and then decreases toward the...
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Noise induced quiescence of epileptic spike generation in patients with epilepsy
Clinical scalp electroencephalographic recordings from patients with epilepsy are distinguished by the presence of epileptic discharges i.e. spikes...
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Applications of single-cell RNA sequencing in drug discovery and development
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods, together with associated computational tools and the growing...
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Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression
Altered transcription is a cardinal feature of acute myeloid leukemia (AML); however, exactly how mutations synergize to remodel the epigenetic...
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Dynamical flexible inference of nonlinear latent factors and structures in neural population activity
Modelling the spatiotemporal dynamics in the activity of neural populations while also enabling their flexible inference is hindered by the...
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Cardiac Pacemaking Is an Emergent Property of Complex Synchronized Signaling on Multiple Scales
The generation of automaticity in the sinoatrial node is a multiscale process involving the integration of complex biochemical and biophysical...
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LCADNet: a novel light CNN architecture for EEG-based Alzheimer disease detection
Alzheimer’s disease (AD) is a progressive and incurable neurologi-cal disorder with a rising mortality rate, worsened by error-prone, time-intensive,...
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The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability
BackgroundCancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor...
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Context-specific Polycomb mechanisms in development
Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of lineage-inappropriate genes and are therefore required for...
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Monosynaptic inference via finely-timed spikes
Observations of finely-timed spike relationships in population recordings have been used to support partial reconstruction of neural microcircuit...
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Arginine vasopressin in the medial amygdala causes greater post-stress recruitment of hypothalamic vasopressin neurons
Arginine vasopressin (AVP) is expressed in both hypothalamic and extra-hypothalamic neurons. The expression and role of AVP exhibit remarkable...
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Dissecting cell fate dynamics in pediatric glioblastoma through the lens of complex systems and cellular cybernetics
Cancers are complex dynamic ecosystems. Reductionist approaches to science are inadequate in characterizing their self-organized patterns and...
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A quantum physics layer of epigenetics: a hypothesis deduced from charge transfer and chirality-induced spin selectivity of DNA
BackgroundEpigenetic mechanisms are informational cellular processes instructing normal and diseased phenotypes. They are associated with DNA but...
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Uncertain prediction of deformable image registration on lung CT using multi-category features and supervised learning
The assessment of deformable registration uncertainty is an important task for the safety and reliability of registration methods in clinical...
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Epigenetics and Aging
In this chapter, we will discuss that the epigenome has a memory function in both somatic and germ cells. The latter is the basis for...