Search
Search Results
-
Size matters: the impact of nucleus size on results from spatial transcriptomics
BackgroundVisium Spatial Gene Expression (ST) is a method combining histological spatial information with transcriptomics profiles directly from...
-
Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression
Astrocytes are one of the brain’s major cell types and are responsible for maintaining neuronal homeostasis via regulating the extracellular...
-
Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway
Heart failure with preserved ejection fraction (HFpEF) is closely associated with metabolic derangement. Sodium glucose cotransporter-2 inhibitors...
-
Relationship between sex biases in gene expression and sex biases in autism and Alzheimer’s disease
BackgroundSex differences in the brain may play an important role in sex-differential prevalence of neuropsychiatric conditions.
Methods ...
-
Influenza A Virus: Cellular Entry
The frequent emergence of pathogenic viruses with pandemic potential has posed a significant threat to human health and economy, despite enormous...
-
Analysis and experimental validation of necroptosis-related molecular classification, immune signature and feature genes in Alzheimer’s disease
Necroptosis, a programmed cell death pathway, has been demonstrated to be activated in Alzheimer’s disease (AD). However, the precise role of...
-
Single-nucleus transcriptomic analysis reveals the relationship between gene expression in oligodendrocyte lineage and major depressive disorder
BackgroundMajor depressive disorder (MDD) is a common mental illness that affects millions of people worldwide and imposes a heavy burden on...
-
Adeno-associated virus-mediated trastuzumab delivery to the central nervous system for human epidermal growth factor receptor 2+ brain metastasis
Trastuzumab improves overall survival for HER2+ breast cancer, but its short half-life in the cerebrospinal fluid (~2–4 days) and delivery...
-
Dynamics of peripheral T cell exhaustion and monocyte subpopulations in neurocognitive impairment and brain atrophy in chronic HIV infection
BackgroundHIV-associated neurocognitive disorders (HAND) is hypothesized to be a result of myeloid cell-induced neuro-inflammation in the central...
-
Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis
Rasmussen encephalitis (RE) is a rare childhood neurological disease characterized by progressive unilateral loss of function, hemispheric atrophy...
-
Single-nucleus RNA sequencing and deep tissue proteomics reveal distinct tumour microenvironment in stage-I and II cervical cancer
BackgroundCervical cancer (CC) is the 3 rd most common cancer in women and the 4 th leading cause of deaths in gynaecological malignancies, yet the...
-
Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols
Macroglia (astrocytes and oligodendrocytes) are required for normal development and function of the central nervous system, yet many questions remain...
-
CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice
Methamphetamine (Meth), a commonly used central nervous system stimulant, is highly addictive. Currently, there is no effective treatment for Meth...
-
Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis
Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination of the central nervous system (CNS). Autologous hematopoietic cell...
-
Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain
A key aspect of nearly all single-cell sequencing experiments is dissociation of intact tissues into single-cell suspensions. While many protocols...
-
In silico stress fibre content affects peak strain in cytoplasm and nucleus but not in the membrane for uniaxial substrate stretch
Existing in silico models for single cell mechanics feature limited representations of cytoskeletal structures that contribute substantially to the...
-
Process Analysis and Parameter Selection of Cardiomyocyte Electroporation Based on the Finite Element Method
PurposePulsed-field ablation (PFA) has attracted attention for the treatment of atrial fibrillation. This study aimed to further explore the...
-
Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer’s disease
The gene-regulatory landscape of the brain is highly dynamic in health and disease, coordinating a menagerie of biological processes across distinct...
-
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory cancer. Molecular stratification in pancreatic cancer remains...
-
Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens
Single-cell genomics enables dissection of tumor heterogeneity and molecular underpinnings of drug response at an unprecedented resolution
1 –11 ....