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Rationale and design of the Diet Restriction and Exercise-induced Adaptations in Metastatic breast cancer (DREAM) study: a 2-arm, parallel-group, phase II, randomized control trial of a short-term, calorie-restricted, and ketogenic diet plus exercise during intravenous chemotherapy versus usual care
BackgroundAn underlying cause of solid tumor resistance to chemotherapy treatment is diminished tumor blood supply, which leads to a hypoxic...
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Fasting to enhance Cancer treatment in models: the next steps
Short-term fasting (STF) is a technique to reduce nutrient intake for a specific period. Since metabolism plays a pivotal role in tumor progression,...
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Fitness correlates of blubber oxidative stress and cellular defences in grey seals (Halichoerus grypus): support for the life-history-oxidative stress theory from an animal model of simultaneous lactation and fasting
Life-history-oxidative stress theory predicts that elevated energy costs during reproduction reduce allocation to defences and increase cellular...
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Effects of short-term warm water immersion on cardiac baroreflex sensitivity in healthy men
Warm water immersion (WWI) causes dizziness presumably due to a substantial drop of blood pressure. The aim of this study was to elucidate the...
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Effects of short-term methionine and cysteine restriction and enrichment with polyunsaturated fatty acids on oral glucose tolerance, plasma amino acids, fatty acids, lactate and pyruvate: results from a pilot study
ObjectiveIn this 7-day pilot study we randomized healthy, normal-weight men and women to either a dietary intervention with methionine and cysteine...
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Effect of a 1-year tailored exercise program according to cancer trajectories in patients with breast cancer: study protocol for a randomized controlled trial
BackgroundPatients with breast cancer undergo various treatments according to their tumor subtype and cancer stages within 1 year after being...
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Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest
PurposeTo compare endocrine responses to intermittent vs continuous enteral nutrition provision during short-term bed rest.
MethodsTwenty healthy...
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Novel Nutritional Therapies for Cancer Treatment and Their Possible Immunological Pathways
Cancer is one of the world’s leading severe illnesses. Cancer incidence is expected to rise further over the globe due to an aging population and the...
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The Natural Course of Impaired Fasting Glucose
Impaired glucose regulation, including diabetes and prediabetes, poses a huge global problem not only in health but also in the epidemiological and...
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Food For Thought: Short-Term Fasting Upregulates Glucose Transporters in Neurons and Endothelial Cells, But Not in Astrocytes
Our group previously reported that 6-h fasting increased both insulin II mRNA expression and insulin level in rat hypothalamus. Given that insulin...
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Lack of detectable short-term effects of a single dose of ivermectin on the human immune system
BackgroundIvermectin is widely used in human and animal medicine to treat and prevent parasite nematode infections. It has been suggested that its...
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Immune-Inflammatory, Metabolic, Oxidative, and Nitrosative Stress Biomarkers Predict Acute Ischemic Stroke and Short-Term Outcome
Immune-inflammatory, metabolic, oxidative, and nitrosative stress (IMO&NS) pathways and, consequently, neurotoxicity are involved in acute ischemic...
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Exercise training and vascular heterogeneity in db/db mice: evidence for regional- and duration-dependent effects
Exercise training (ET) has several health benefits; however, our understanding of regional adaptations to ET is limited. We examined the functional...
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Associations of diabetes, circulating protein biomarkers, and risk of pancreatic cancer
BackgroundType 2 diabetes (T2D) is associated with higher risk of pancreatic cancer (PC), but the underlying mechanisms are not fully understood.
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The Effect of Short-Term Feeding of a High-Coconut Oil or High-Fat Diet on Neuroinflammation and the Performance of an Object–Place Task in Rats
The consumption of high-fat and high-sugar diets, in the form of junk food, and binge eating are now common. Increasing evidence suggests that a...
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Biomarkers in Experimental Diabetes: Studies with Syzygium Cumini (L.) and Links with the Sulfonylurea 1 Receptor
Diabetes mellitus (DM) is showing a global rise in its incidence. Pancreatic beta cell dysfunction, insulin resistance, and inflammation contribute...
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Skip** breakfast does not accelerate the hyperglycemia-induced endothelial dysfunction but reduces blood flow of the brachial artery in young men
PurposePostprandial hyperglycemia is assumed to have a negative impact on flow-mediated dilation (FMD), an index of endothelial function, and blood...
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Effectiveness of high cardiorespiratory fitness in cardiometabolic protection in prediabetic rats
BackgroundCaloric restriction and exercise are lifestyle interventions that effectively attenuate cardiometabolic impairment. However,...
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The effects of an exercise program on inflammation in adults who differ according to obstructive sleep apnea severity
Exercise improves chronic inflammation and is recommended as a first-line medical or behavioral treatment for OSA with obesity. We examined whether...
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Characterization of Risk Factors for Modeling of Type 2 Diabetes Mellitus Induced by a High-Fat Diet in C57BL/6 Mice
Type 2 diabetes mellitus develops due to a combination of genetic and environmental factors. C57BL/6 mice prone to obesity and leptin resistance were...