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Do uterine PTGS2, PGFS, and PTGFR expression play a role in canine uterine inertia?
The aetiology of primary uterine inertia (PUI), which is the most common cause of canine dystocia, is still not elucidated. Prostaglandins (PGs) play...
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Association between postoperative cough and thyroidectomy: a prospective study
BackgroundThis study sought to determine whether thyroidectomy is associated with self-reported cough through a prospective analysis.
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Hypercalcemia of Malignancy
This chapter discusses hypercalcemia of malignancy which is the commonest biochemical complication of cancer and recognized as a medical emergency....
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Is prophylaxis for osteoporosis indicated after acute spinal cord injury?
Spinal cord injury (SCI)-related osteoporosis is common complication in people with tetraplegia or paraplegia. Studies have shown that sublesional...
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A phase Ib study of entinostat plus lapatinib with or without trastuzumab in patients with HER2-positive metastatic breast cancer that progressed during trastuzumab treatment
BackgroundHuman epidermal growth factor 2 (HER2) is an effective therapeutic target in breast cancer; however, resistance to anti-HER2 agents such as...
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Dengue fever manifesting with tetany as the first presentation of primary hypoparathyroidism: a case report
BackgroundPrimary hypoparathyroidism is associated with diverse variety of symptomatology of hypocalcemia including seizures and tetany. We report a...
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Effects of butyrateâ on ruminal Ca2+ transport: evidence for the involvement of apically expressed TRPV3 and TRPV4 channels
The ruminal epithelium absorbs large quantities of NH 4 + and Ca 2+ . A role for TRPV3 has emerged, but data on TRPV4 are lacking. Furthermore,...
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Pain and Pain Management
Pain is one of the most common symptoms encountered in palliative medicine. Good pain management involves ensuring pain is screened for, adequately...
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Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi)
Inorganic phosphate (Pi) is an abundant element in the body and is essential for a wide variety of key biological processes. It plays an essential...
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Strongyloides stercoralis infection in imported and local dogs in Switzerland: from clinics to molecular genetics
Strongyloides stercoralis is a worldwide-distributed intestinal nematode affecting mainly humans and dogs. Canine strongyloidosis is generally...
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Tumor Lysis Syndrome
Tumor lysis syndrome refers to the laboratory and clinical results of rapid breakdown of high volumes of malignant cells. Significant electrolyte...
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Neurological Symptoms
Neurological disease is a major cause of disability and death across the world. There is increasing evidence that palliative care is effective in...
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Effect of early treatment with zoledronic acid on prevention of bone loss in patients with acute spinal cord injury: a randomized controlled trial
Study designRandomized controlled trial.
ObjectivesTo determine the effect of zoledronic acid on bone loss in people with acute spinal cord injury...
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A systematic review of lenvatinib and sorafenib for treating progressive, locally advanced or metastatic, differentiated thyroid cancer after treatment with radioactive iodine
BackgroundTreatment with radioactive iodine is effective for many patients with progressive, locally advanced or metastatic, differentiated thyroid...
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Advances in therapeutic peptides targeting G protein-coupled receptors
Dysregulation of peptide-activated pathways causes a range of diseases, fostering the discovery and clinical development of peptide drugs. Many...
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Pathogenic copy number variants that affect gene expression contribute to genomic burden in cerebral palsy
Cerebral palsy (CP) is the most frequent movement disorder of childhood affecting 1 in 500 live births in developed countries. We previously...
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Peripheral Neuropathy, Episodic Rhabdomyolysis, and Hypoparathyroidism in a Patient with Mitochondrial Trifunctional Protein Deficiency
A combination of unexplained peripheral neuropathy, hypoparathyroidism, and the inability to cope with metabolic stress could point to a rare inborn...
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Zebrafish is a predictive model for identifying compounds that protect against brain toxicity in severe acute organophosphorus intoxication
Acute organophosphorus (OP) intoxication is a worldwide clinical and public health problem. In addition to cholinergic crisis, neurodegeneration and...
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The Developmental Origins of Osteoporosis
OsteoporosisOsteoporosis is a disease characterised by poor bone strength and microarchitecture, causing bone fragilityBone fragility, which leads...