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Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling
Phosphoglycerate dehydrogenase (PHGDH) has emerged as a crucial factor in macromolecule synthesis, neutralizing oxidative stress, and regulating...
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Benzoylaconine Modulates LPS-Induced Responses Through Inhibition of Toll-Like Receptor-Mediated NF-κB and MAPK Signaling in RAW264.7 Cells
Previous studies have shown that benzoylaconine (BAC), a representative monoester alkaloid, has a potential anti-inflammatory effect. This study...
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Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation
BackgroundThe involvement of the autonomic nervous system in the regulation of inflammation is an emerging concept with significant potential for...
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5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages
BackgroundAcute lung injury (ALI) arises from sepsis or bacterial infection, which are life-threatening respiratory disorders that cause the leading...
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Monophosphoryl lipid A ameliorates radiation-induced lung injury by promoting the polarization of macrophages to the M1 phenotype
BackgroundRadiation-induced lung injury (RILI) often occurs during clinical chest radiotherapy and acute irradiation from accidental nuclear leakage....
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Targeting the lipid metabolic reprogramming of tumor-associated macrophages: A novel insight into cancer immunotherapy
BackgroundTumor-associated macrophages, as the major immunocytes in solid tumors, show divided loyalty and remarkable plasticity in tumorigenesis....
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Polarization Profiles of T Lymphocytes and Macrophages Responses in Periodontitis
Periodontitis is a multifactorial, chronic inflammatory disease affecting the supporting structures of teeth triggered by the complex interactions...
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Siglec-15 on macrophages suppress the immune microenvironment in patients with PD-L1 negative non-metastasis lung adenocarcinoma
Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is an immune checkpoint molecule with sequence homology to programmed cell death ligand...
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Thymoquinone Effect on Leishmania tropica/infantum and Leishmania-Infected Macrophages
IntroductionLeishmania is a parasitic protozoan that tries to enter and amplify within macrophages. Macrophage cells are also immune defense cells...
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Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapy
BackgroundPlatinum-drugs based chemotherapy in clinic increases the potency of tumor cells to produce M2 macrophages, thus leading to poor...
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Tumor-Associated Macrophages: Therapeutic Targets of Cancer
It has been widely known that macrophages play critical roles during infection and immune responses. While as tumor-infiltrating myeloid cells,...
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Impact of a long-term high-glucose environment on pro-inflammatory responses in macrophages stimulated with lipopolysaccharide
Cumulative evidence has established that macrophages orchestrate inflammatory responses that crucially contribute to the pathogenesis of...
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Saccharomyces cerevisiae β-glucan improves the response of trained macrophages to severe P. aeruginosa infections
Objective P. Aeruginosa(PA), the major pathogen of lung cystic fibrosis (CF), polarizes macrophages into hyperinflammatory tissue damaging phenotype....
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Cavin-1 promotes M2 macrophages/microglia polarization via SOCS3
PurposeOur study aimed to investigate the function of Cavin-1 and SOCS3 in macrophages/microglia M2 polarization and further explored the relevant...
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Synthetic retinoid-mediated preconditioning of cancer-associated fibroblasts and macrophages improves cancer response to immune checkpoint blockade
BackgroundThe proliferation of cancer-associated fibroblasts (CAFs) hampers drug delivery and anti-tumor immunity, inducing tumor resistance to...
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Role of ATF3 triggering M2 macrophage polarization to protect against the inflammatory injury of sepsis through ILF3/NEAT1 axis
BackgroundSepsis is a systemic inflammatory response which is frequently associated with acute lung injury (ALI). Activating transcription factor 3...
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M1 But Not M0 Extracellular Vesicles Induce Polarization of RAW264.7 Macrophages Via the TLR4-NFκB Pathway In Vitro
In response to different stimuli ( e.g. , infections), naive macrophages polarize into M1 macrophages, which have the potential to secrete numerous...
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Delivery of siRNA to Macrophages: Challenges and Opportunities
The discovery of the RNA interference (RNAi) pathway in 1998 and small interfering RNA (siRNA) in 2001 have paved the wave for gene targeting and...
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The role of lung macrophages in acute respiratory distress syndrome
Acute respiratory distress syndrome (ARDS) is an acute and diffuse inflammatory lung injury in a short time, one of the common severe manifestations...
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PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis
Background and objectiveProgranulin (PGRN), a multifunctional growth factor, plays indispensable roles in the regulation of cancer, inflammation,...
