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Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain
Tau seed amplification assays (SAAs) directly measure the seeding activity of tau and would therefore be ideal biomarkers for clinical trials...
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Introduction of a multiplex amplicon sequencing assay to quantify DNA methylation in target cytosine markers underlying four selected epigenetic clocks
BackgroundDNA methylation analysis has proven to be a powerful tool for age assessment. However, the implementation of epigenetic age prediction in...
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A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics
The rapid repurposing of antivirals is particularly pressing during pandemics. However, rapid assays for assessing candidate drugs typically involve...
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Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip
Creating in vitro models of diseases of the pancreatic ductal compartment requires a comprehensive understanding of the developmental trajectories of...
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AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis
BackgroundBasal-like breast cancer (BLBC) is the most aggressive subtype of breast cancer due to its aggressive characteristics and lack of effective...
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The MYBL2–CCL2 axis promotes tumor progression and resistance to anti-PD-1 therapy in ovarian cancer by inducing immunosuppressive macrophages
BackgroundAn immunosuppressive tumor microenvironment in ovarian cancer facilitates tumor progression and resistance to immunotherapy. The function...
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Microfluidic Systems and Organ (Human) on a Chip
In the previous chapters we learned how cells are cultivated in 3D and how the surrounding gel matrix is optimized. However, to achieve even higher...
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Chromatin Immunoprecipitation from Formaldehyde Cross-Linked Olfactory Sensory Neurons
Chromatin immunoprecipitation (ChIP) allows a researcher to determine the genomic occupancy of nuclear proteins, providing insight into the roles of...
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A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke
The therapeutic efficacy of stem cells transplanted into an ischaemic brain depends primarily on the responses of the neurovascular unit. Here, we...
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Droplet-Based Microfluidic Chip Design, Fabrication, and Use for Ultrahigh-Throughput DNA Analysis and Quantification
DNA is widely used as a biomarker of contamination, infection, or disease, which has stimulated the development of a wide palette of detection and...
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The HIFIA/LINC02913/IGF1R axis promotes the cell function of adipose-derived mesenchymal stem cells under hypoxia via activating the PI3K/AKT pathway
ObjectivePromoting angiogenesis is crucial for tissue repair. Adipose-derived mesenchymal stem cells (ADSCs) are endowed with the ability of...
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The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration
BackgroundMyelin sheath is a crucial accessory to the functional nerve-fiber unit, its disruption or loss can lead to axonal degeneration and...
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E2F1 combined with LINC01004 super-enhancer to promote hepatocellular carcinoma cell proliferation and metastasis
IntroductionSuper-enhancer-associated lncRNAs play important roles in the occurrence and development of malignant tumors, including hepatocellular...
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Integrative analysis of a novel super-enhancer-associated lncRNA prognostic signature and identifying LINC00945 in aggravating glioma progression
BackgroundSuper-enhancers (SEs), driving high-level expression of genes with tumor-promoting functions, have been investigated recently. However, the...
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ATF3-induced activation of NF-κB pathway results in acquired PARP inhibitor resistance in pancreatic adenocarcinoma
PurposeOlaparib, an inhibitor of poly-(adenosine diphosphate-ribose) polymerase (PARP), has been shown to have anticancer benefits in patients with...
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PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer
BackgroundAberrant epigenetic remodeling events contribute to progression and metastasis of breast cancer (Bca). The specific mechanims that...
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Development of an ultra-sensitive human IL-33 biomarker assay for age-related macular degeneration and asthma drug development
BackgroundOver the past decade, human Interleukin 33 (hIL-33) has emerged as a key contributor to the pathogenesis of numerous inflammatory diseases....
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PAQR5 inhibits the growth and metastasis of clear cell renal cell carcinoma by suppressing the JAK/STAT3 signaling pathway
BackgroundClear cell renal cell carcinoma (ccRCC) has a high degree of malignancy and poor overall prognosis in advanced and metastatic patients....
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Gene expression analysis in NSAID-induced rat small intestinal disease model with the intervention of berberine by the liquid chip technology
ObjectiveInvestigate the effect and mechanism of berberine on the small intestinal mucosa of non-steroidal anti-inflammatory drugs (NSAIDs) related...
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P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC
BackgroundN7-methylguanosine (m7G) modification is, a more common epigenetic modification in addition to m6A modification, mainly found in mRNA...
