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Itraconazole Confers Cytoprotection Against Neurodegenerative Disease-Associated Abnormal Protein Aggregation
Cells perform regular maintenance to avoid the accumulation of misfolded proteins. Prolonged accumulation of these proteotoxic inclusions generates...
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Integrated Proteomics and Protein Co-expression Network Analysis Identifies Novel Epileptogenic Mechanism in Mesial Temporal Lobe Epilepsy
Over 50 million people worldwide are affected by epilepsy, a common neurological disorder that has a high rate of drug resistance and diverse...
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The first Autumn School on Proteostasis: from molecular mechanisms to organismal consequences
The first Autumn School on Proteostasis was held at the Mediterranean Institute for Life Sciences (MedILS) in Split, Croatia, from November...
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Naturally occurring small molecules with dual effect upon inflammatory signaling pathways and endoplasmic reticulum stress response
The endoplasmic reticulum (ER) is determinant to maintain cellular proteostasis. Upon unresolved ER stress, this organelle activates the unfolded...
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Tenth International Symposium on the Hsp90 chaperone machine
Hsp90 is a molecular chaperone responsible for regulating proteostasis under physiological and pathological conditions. Its central role in a range...
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Crosstalk Between Autophagy and Nutrigenomics in Neurodegenerative Diseases
Proteostasis refers to the dynamic regulation of protein homeostasis which is mediated by a network of molecular machines responsible for both...
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Concept and application of circulating proteasomes
Proteostasis is primarily a function of protein synthesis and degradation. Although the components and processes involved in intracellular...
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Multivalent protein–protein interactions are pivotal regulators of eukaryotic Hsp70 complexes
Heat shock protein 70 (Hsp70) is a molecular chaperone and central regulator of protein homeostasis (proteostasis). Paramount to this role is Hsp70’s...
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How to fix a broken protein: restoring function to mutant human cystathionine β-synthase
Inborn errors of metabolism (IEM) comprise a large class of recessive genetic diseases involving disorders of cellular metabolism that tend to be...
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Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer’s disease
Amyloid precursor protein (APP) metabolism is central to Alzheimer’s disease (AD) pathogenesis, but the key etiological driver remains elusive....
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Calreticulin: a quintessential multifaceted protein with therapeutic potential
Calreticulin is primarily an endoplasmic reticulum (ER) resident protein which has also been identified at different cellular sites. Its...
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Using Single-Molecule Fluorescence Microscopy to Uncover Neuronal Vulnerability to Protein Damage
Neurodegenerative disorders (NDs) are diverse age-related conditions also described as “conformational diseases.” The hallmark of NDs is the...
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Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A -rearranged ( KMT2A-r ) acute myeloid...
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Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma
BackgroundChaperonin-containing tailless complex polypeptide 1 (TCP1) subunit 3 (CCT3) has tumor-promoting effects in lung adenocarcinoma (LUAD)....
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Neuroepigenetic Changes in DNA Methylation Affecting Diabetes-Induced Cognitive Impairment
Chronic diabetic conditions have been associated with certain cerebral complications, that include neurobehavioral dysfunctional patterns and...
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Therapeutic Role of a Cysteine Precursor, OTC, in Ischemic Stroke Is Mediated by Improved Proteostasis in Mice
Oxidative stress aggravates brain injury following ischemia/reperfusion (I/R). We previously showed that ubiquilin-1 (Ubqln1), a ubiquitin-like...
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Utilization of fluid-based biomarkers as endpoints in disease-modifying clinical trials for Alzheimer’s disease: a systematic review
BackgroundClinical trials in Alzheimer’s disease (AD) had high failure rates for several reasons, including the lack of biological endpoints....
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Autophagy Dysfunction in ALS: from Transport to Protein Degradation
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting upper and lower motor neurons (MNs). Since the identification of...
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Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson’s disease
Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, which is characterized by the progressive loss of dopaminergic...
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Withaferin A Induces Heat Shock Response and Ameliorates Disease Progression in a Mouse Model of Huntington’s Disease
Impairment of proteostasis network is one of the characteristic features of many age-related neurodegenerative disorders including autosomal...
