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Aberrant expression of GSTM5 in lung adenocarcinoma is associated with DNA hypermethylation and poor prognosis
BackgroundGlutathione-S transferases (GSTs) comprise a series of critical enzymes involved in detoxification of endogenous or xenobiotic compounds....
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Bacteria pathogens drive host colonic epithelial cell promoter hypermethylation of tumor suppressor genes in colorectal cancer
BackgroundAltered microbiome composition and aberrant promoter hypermethylation of tumor suppressor genes (TSGs) are two important hallmarks of...
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Hypermethylation of TMEM240 predicts poor hormone therapy response and disease progression in breast cancer
BackgroundApproximately 25% of patients with early-stage breast cancer experience cancer progression throughout the disease course. Alterations in TMEM240...
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Hypermethylation of PDX1, EN2, and MSX1 predicts the prognosis of colorectal cancer
Despite numerous observations regarding the relationship between DNA methylation changes and cancer progression, only a few genes have been verified...
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Pervasive promoter hypermethylation of silenced TERT alleles in human cancers
BackgroundIn cancers, maintenance of telomeres often occurs through activation of the catalytic subunit of telomerase, encoded by TERT . Yet, most...
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Promoter Hypomethylation Upregulates ANXA2 Expression in Pancreatic Cancer and is Associated with Poor Prognosis
Pancreatic cancer (PC) is one of the world’s most aggressive and deadly cancers, owing to non-specific early clinical symptoms, late-stage diagnosis,...
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Promoter methylation-regulated miR-148a-3p inhibits lung adenocarcinoma (LUAD) progression by targeting MAP3K9
Lung adenocarcinoma (LUAD) characterized by high metastasis and mortality is the leading subtype of non-small cell lung cancer. Evidence shows that...
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PCDH17 gene promoter methylation status in a cohort of Egyptian women with epithelial ovarian cancer
Background and objectiveOvarian cancer is a leading cause of female mortality. Epigenetic changes occur in early stages of carcinogenesis and...
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M2 Macrophage-Derived Exosomes Regulate miR-199a-3p Promoter Methylation Through the LINC00470-Mediated myc/DNMT3a Axis to Promote Breast Cancer Development
Breast cancer (BC) is the most common invasive cancer in women. M2 macrophage exosomes promote cancer development and play multiple roles in the...
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Hypermethylation of heparanase 2 promotes colorectal cancer proliferation and is associated with poor prognosis
BackgroundThe epigenetic abnormality of tumor-associated genes contributes to the pathogenesis of colorectal carcinoma (CRC). However, methylation in...
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The prognostic value and immune correlation of IL18 expression and promoter methylation in renal cell carcinoma
BackgroundRenal cell carcinoma (RCC) is not sensitive to immunotherapy and has poor prognosis. DNA methylation regulates gene expression, and its...
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BDNF exon IV promoter methylation and antidepressant action: a complex interplay
BackgroundBDNF exon IV promoter methylation is a potential biomarker for treatment response to antidepressants in MDD. We have previously shown...
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Aberrant hydroxymethylation in promoter CpG regions of genes related to the cell cycle and apoptosis characterizes advanced chronic myeloid leukemia disease, poor imatinib respondents and poor survival
BackgroundThere is strong evidence that disease progression, drug response and overall clinical outcomes of CML disease are not only decided by...
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Hypermethylation of Long Non-Coding RNA Genes Group in the Breast Cancer Development and Progression
We analyzed changes in the level of methylation of CpG islands in four long non-coding RNA (lncRNA) genes MEG3 , ZNF667-AS1 , GAS5 , and SEMA3B-AS1 as...
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SOX14 hypermethylation as a tumour biomarker in cervical cancer
BackgroundThe association between SOX14 and cancer has been reported. The aim of this study was to identify and validate the potential value of SOX14...
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The influence of Nrf2 gene promoter methylation on gene expression and oxidative stress parameters in preeclampsia
Background and aimsPreeclampsia (PE) is a serious medical condition that usually causes high blood pressure and affects multiple organs. Considering...
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CpG Methylation of the Proximal Promoter Region Regulates the Expression of NAC6D Gene in Response to High Temperature in Wheat (Triticum aestivum)
AbstractMethylation of DNA promoter sequences at the CpG islands has become a molecular tool for gene regulation. NAC6D gene is induced by different...
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Evaluating the link between DIO3-FA27 promoter methylation, biochemical indices, and heart failure progression
BackgroundHeart failure (HF) is a disease that poses a serious threat to individual health, and DNA methylation is an important mechanism in...
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Inhibitory immune checkpoints PDCD-1 and LAG-3 hypermethylation may reduce the risk of colorectal cancer
BackgroundChanges in DNA methylation of immunosuppressive checkpoints may impact express and consequently affect antigen processing and presentation...
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DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma
BackgroundAdrenocortical carcinoma is rare and aggressive endocrine cancer of the adrenal gland. Within adrenocortical carcinoma, a recently...
