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Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1
Specific and selective anti-CB 1 antibodies are among the most powerful research tools to unravel the complex biological processes mediated by the CB 1 ...
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Nanoscale Molecular Imaging of Presynaptic Active Zone Proteins in Cultured Hippocampal Neurons
Neurotransmitter release occurs at a specialized region of the nerve terminal known as the presynaptic active zone, where a large number of synaptic...
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Involvement of the Voltage-Gated Calcium Channels L- P/Q- and N-Types in Synapse Elimination During Neuromuscular Junction Development
During the nervous system development, synapses are initially overproduced. In the neuromuscular junction (NMJ) however, competition between several...
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α-Synuclein induced cholesterol lowering increases tonic and reduces depolarization-evoked synaptic vesicle recycling and glutamate release
α-Synuclein (α-syn) is a key molecule linked to Parkinson’s disease pathology. Physiologically, the monomeric α-syn in the presynaptic termini is...
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Immunohistochemical distribution of proteins involved in glutamate release in subepithelial sensory nerve endings of rat epiglottis
To elucidate the efferent functions of sensory nerve endings, the distribution of calretinin and vesicular glutamate transporter 1 (VGLUT1) in...
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Neuromuscular Junction Dysfunction in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by progressive degeneration of motor neurons leading to skeletal...
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Electrophysiology of Dendritic Spines: Information Processing, Dynamic Compartmentalization, and Synaptic Plasticity
For many years, synaptic transmission was considered as information transfer between presynaptic neuron and postsynaptic cell. At the synaptic level,...
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Cell Biology of the Synapse
Synapses are the sites of contact between nerve cells. Synapses convert electrical signals into chemical information, which is conveyed between...
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Postsynaptic synucleins mediate endocannabinoid signaling
Endocannabinoids are among the most powerful modulators of synaptic transmission throughout the nervous system, and yet little is understood about...
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Role of the endocannabinoid system in fragile X syndrome: potential mechanisms for benefit from cannabidiol treatment
Multiple lines of evidence suggest a central role for the endocannabinoid system (ECS) in the neuronal development and cognitive function and in the...
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Synaptosomal Preparation and Its Application in Preclinical Studies
Here we reviewed both established and emerging approaches to study the synaptic function. After an overview on the synaptic morphology and function,...
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Distinct Effects of BDNF and NT-3 on the Dendrites and Presynaptic Boutons of Develo** Olfactory Bulb GABAergic Interneurons In Vitro
Brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3) are known to regulate neuronal morphology and the formation of neural circuits,...
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Bassoon contributes to tau-seed propagation and neurotoxicity
Tau aggregation is a defining histopathological feature of Alzheimer’s disease and other tauopathies. However, the cellular mechanisms involved in...
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Association of variants in the KIF1A gene with amyotrophic lateral sclerosis
BackgroundAmyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease that affects neurons in the central nervous...
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The developmental timing of spinal touch processing alterations predicts behavioral changes in genetic mouse models of autism spectrum disorders
Altered somatosensory reactivity is frequently observed among individuals with autism spectrum disorders (ASDs). Here, we report that although...
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Trophic Factors: Neurotrophic Factors
Neurotrophic factors support survival, process outgrowth, and phenotypic differentiation of neurons during development. Many neurotrophic factors are...
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Electrophysiological and Visual Tags
Just like we can identify friends based on physical characteristics (voice, appearance, etc.), so too can we identify synaptic proteins or neurons...
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Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson's disease
Deep brain stimulation (DBS) is a well-established and effective treatment for patients with advanced Parkinson's disease (PD), yet its underlying...
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Expanding the genetic and phenotypic spectrum of congenital myasthenic syndrome: new homozygous VAMP1 splicing variants in 2 novel individuals
We report the cases of two Spanish pediatric patients with hypotonia, muscle weakness and feeding difficulties at birth. Whole-exome sequencing (WES)...
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Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease
Retina and optic nerve are sites of extra-cerebral manifestations of Alzheimer’s Disease (AD). Amyloid-β (Aβ) plaques and neurofibrillary tangles of...
