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Digital biomarkers and sex impacts in Alzheimer’s disease management — potential utility for innovative 3P medicine approach
Digital biomarkers are defined as objective, quantifiable physiological and behavioral data that are collected and measured by means of digital...
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Artificial intelligence in ovarian cancer drug resistance advanced 3PM approach: subtype classification and prognostic modeling
BackgroundOvarian cancer patients’ resistance to first-line treatment posed a significant challenge, with approximately 70% experiencing recurrence...
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Development and validation of a routine blood parameters-based model for screening the occurrence of retinal detachment in high myopia in the context of PPPM
Background/aimsTimely detection and treatment of retinal detachment (RD) could effectively save vision and reduce the risk of progressing visual...
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Fecal Microbiota Transplantation in Diseases Not Associated with Clostridium difficile: Current Status and Future Therapeutic Option
Fecal microbiota transplantation (FMT) is one of several effective methods for modifying altered intestinal microbiota and treating certain...
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Quantitative phosphoproteomics reveals molecular pathway network alterations in human early-stage primary hepatic carcinomas: potential for 3P medical approach
ObjectiveHepatic carcinoma is one of the most common types of malignant tumors in the digestive system, and its biological characteristics determine...
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Challenging management of severe chronic disorders in acute pandemic situation: Chronic liver disease under COVID-19 pandemic as the proof-of-principle model to orchestrate the measures in 3PM context
Chronic liver disease management is a comprehensive approach requiring multi-professional expertise and well-orchestrated healthcare measures...
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Clinically relevant stratification of lung squamous carcinoma patients based on ubiquitinated proteasome genes for 3P medical approach
RelevanceThe proteasome is a crucial mechanism that regulates protein fate and eliminates misfolded proteins, playing a significant role in cellular...
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Multi-risk factors joint prediction model for risk prediction of retinopathy of prematurity
PurposeRetinopathy of prematurity (ROP) is a retinal vascular proliferative disease common in low birth weight and premature infants and is one of...
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Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications—risks and mitigation
Proliferative diabetic retinopathy (PDR) the sequel of diabetic retinopathy (DR), a frequent complication of diabetes mellitus (DM), is the leading...
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Vascular dysregulation in glaucoma: retinal vasoconstriction and normal neurovascular coupling in altitudinal visual field defects
PurposeVision loss in glaucoma is not only associated with elevated intraocular pressure and neurodegeneration, but vascular dysregulation (VD) is a...
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Association of systemic inflammation indices with visual field loss progression in patients with primary angle-closure glaucoma: potential biomarkers for 3P medical approaches
RelevanceAccumulating evidence suggests a dysfunction of the para-inflammation in the retinal ganglion cell layer and the optic nerve head in...
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Overview of omics biomarkers in pituitary neuroendocrine tumors to design future diagnosis and treatment strategies
Pituitary neuroendocrine tumors (PitNETs) are the second most common type of intracranial neoplasia. Since their manifestation usually causes hormone...
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Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation
Despite their subordination in humans, to a great extent, mitochondria maintain their independent status but tightly cooperate with the “host” on...
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Clinically relevant immune subtypes based on alternative splicing landscape of immune-related genes for lung cancer advanced PPPM approach
BackgroundAlternative splicing (AS) occurs in the process of gene post-transcriptional process, which is very important for the correct synthesis...
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Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways
Inflammation is an essential pillar of the immune defense. On the other hand, chronic inflammation is considered a hallmark of cancer initiation and...
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Immune-related gene methylation prognostic instrument for stratification and targeted treatment of ovarian cancer patients toward advanced 3PM approach
BackgroundDNA methylation is an important mechanism in epigenetics, which can change the transcription ability of genes and is closely related to the...
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Targeting phytoprotection in the COVID-19-induced lung damage and associated systemic effects—the evidence-based 3PM proposition to mitigate individual risks
The risks related to the COVID-19 are multi-faceted including but by far not restricted to the following: direct health risks by poorly understood...
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Positive influence of gut microbiota on the effects of Korean red ginseng in metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial
BackgroundGinseng, a traditional herbal medicine, has been used for thousands of years to treat various diseases including metabolic syndrome (MS)....
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Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes
RelevanceIvermectin, as an old anti-parasite drug, can suppress almost completely the growth of various human cancers, including ovarian cancer (OC)....
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Diabetes Forecasts and Statistics for the Coming Decades
Diabetes has become one of the foremost diseases worldwide, even though growth and prevalence are geographically heterogeneous, according to such...