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A pragmatic randomized controlled trial testing the effects of the international scientific SCI exercise guidelines on SCI chronic pain: protocol for the EPIC-SCI trial
Study designProtocol for a pragmatic randomized controlled trial (the
E xercise guidelineP romotion andI mplementation inC hronic SCI [EPIC-SCI]...
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The PRO-ACTIVE trial protocol: a randomized study comparing the effectiveness of PROphylACTic swallow InterVEntion for patients receiving radiotherapy for head and neck cancer
BackgroundSwallowing therapy is commonly provided as a treatment to lessen the risk or severity of dysphagia secondary to radiotherapy (RT) for head...
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Pragmatics Electrified
The electrical activity of the brain while elaborating linguistic material that is pragmatically charged surfaces in three ERP components (N400,...
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Point prevalence study of antibiotic appropriateness and possibility of early discharge from hospital among patients treated with antibiotics in a Swiss University Hospital
BackgroundThe growing threat of multidrug resistant organisms have led to increasingly promote prudent and rational use of antimicrobials as well as...
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Study protocol for a multicenter randomised controlled trial on the (cost)
e ffectiveness of biopsy combined with same-sessionM R-guided LITT versus biopsy alone in patients with primary irresectable glioblastoma (EMITT trial)BackgroundGlioblastoma (GBM) is the most common primary, malignant brain tumour with a 5-year survival of 5%. If possible, a glioblastoma is resected...
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Test, evidence, transition projects in Scotland: develo** the evidence needed for transition of effective interventions in cancer care from innovation into mainstream practice
BackgroundA robust evidence base is required to assist healthcare commissioners and providers in selecting effective and sustainable approaches to...
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Patients’ perceptions and practices of informing relatives: a qualitative study within a randomised trial on healthcare-assisted risk disclosure
In a multicentre randomised controlled trial (DIRECT), we evaluate whether an intervention of providing direct letters from healthcare professionals...
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EEG and ERPs in the Study of Language and Social Knowledge
Event-related potentials (ERPs) represent the ideal methodological approach for investigating the time course of language reading and comprehension...
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Angiotensin blockade therapy and survival in pancreatic cancer: a population study
BackgroundPancreatic cancer (PC) is one of the most aggressive and challenging cancer types to effectively treat, ranking as the fourth-leading cause...
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The impact of enteric coating of aspirin on aspirin responsiveness in patients with suspected or newly diagnosed ischemic stroke: prospective cohort study: results from the (ECASIS) study
Background and purposeUncertainty remains regarding the impact of enteric-coated aspirin (EC-ASA) on secondary prevention of ischemic stroke compared...
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Teclistamab in relapsed refractory multiple myeloma: multi-institutional real-world study
The objective of our study was to report real-world data on the safety and efficacy of standard-of-care teclistamab in patients with...
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The National COVID Cancer Antibody Survey: a hyper-accelerated study proof of principle for cancer research
The COVID-19 pandemic has led to a range of novel and adaptive research designs. In this perspective, we use our experience coordinating the National...
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Clinical research stakeholders’ experiences of clinical research during COVID-19: a qualitative study
BackgroundThe COVID-19 pandemic created a complex high-risk clinical research environment with clinical research activities significantly impacted....
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The interplay between respectfulness and lexical-semantic in reading Chinese: evidence from ERPs
Language comprehension requires the processing of both linguistic and extra-linguistic information, such as syntax, semantics, and pragmatic...
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Development and validation of the provider assessed quality of consultations with language interpretation scale (PQC-LI)
ObjectiveWith the growing immigrant communities in the western world, there is an urgent need to address language barriers to care, and health...
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Robotic technology (ROBERT®) to enhance muscle strength in the hip flexor muscles following spinal cord injury: a feasibility study
Study designFeasibility study.
ObjectiveTo determine the feasibility of conducting a large trial designed to determine whether the ROBERT ® can be...
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Early and intensive motor training to enhance neurological recovery in people with spinal cord injury: trial protocol
Study designProtocol for a multi-centre randomised controlled trial (the SCI-MT trial).
ObjectivesTo determine whether 10 weeks of intensive motor...
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Real-World Evidence: A Primer
Real-world evidence (RWE) is clinical evidence on a medical product’s safety and efficacy that is generated using real-world data (RWD) resulting...
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Imatinib with intensive chemotherapy in AML with t(9;22)(q34.1;q11.2)/BCR::ABL1. A DATAML registry study
Acute myeloid leukemia (AML) with t(9;22) (q34.1; q11.2)/ BCR::ABL1 , a distinct entity within the group of AML with defining genetic abnormalities,...
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Adolescents’ experiences and views of the national school-based thalassaemia screening programme in Malaysia: a qualitative study
In 2016, a national school-based thalassemia screening programme was implemented in Malaysia. This study aimed to explore the experiences and views...