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Cadonilimab with chemotherapy in HER2-negative gastric or gastroesophageal junction adenocarcinoma: the phase 1b/2 COMPASSION-04 trial
Treatment with anti-programmed cell death protein 1 (PD-1) therapy and chemotherapy prolongs the survival of patients with unresectable advanced or...
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Homogeneous inhibition is optimal for the phase precession of place cells in the CA1 field
Place cells are hippocampal neurons encoding the position of an animal in space. Studies of place cells are essential to understanding the processing...
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Influence of Micro- and Macronutrients on the Clonal Phase of the Adaptive Immune Response
In the clonal defense phase of the adaptive immune response, the defense reaction is implemented by the so-called clonal selection and expansion of...
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Polycomb repression of Hox genes involves spatial feedback but not domain compaction or phase transition
Polycomb group proteins have a critical role in silencing transcription during development. It is commonly proposed that Polycomb-dependent changes...
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RANKL blockade for erosive hand osteoarthritis: a randomized placebo-controlled phase 2a trial
Erosive hand osteoarthritis (OA) is a prevalent and disabling disease with limited treatment options. Here we present the results of a monocentric,...
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Phase separation of low-complexity domains in cellular function and disease
In this review, we discuss the ways in which recent studies of low-complexity (LC) domains have challenged our understanding of the mechanisms...
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Phase separation in immune regulation and immune-related diseases
Phase separation is an emerging paradigm for understanding the biochemical interactions between proteins, DNA, and RNA. Research over the past decade...
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Conspicuity of malignant pleural mesothelioma in contrast enhanced MDCT – arterial phase or late phase?
BackgroundTo determine if late phase is superior to arterial phase intraindividually regarding conspicuity of MPM in contrast enhanced chest MDCT.
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A verification phase adds little value to the determination of maximum oxygen uptake in well-trained adults
PurposeThe objective was to investigate if performing a sub-peak or supra-peak verification phase following a ramp test provides additional value for...
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Phase I study of LZM005 in patients with HER2-positive metastatic breast cancer
The prognosis of human epidermal growth factor receptor 2 (HER2) positive metastatic breast cancer (MBC) remained unsatisfactory currently, more...
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Global research hotspots, development trends and prospect discoveries of phase separation in cancer: a decade-long informatics investigation
Liquid-liquid phase separation (LLPS) is a complex and subtle phenomenon whose formation and regulation take essential roles in cancer initiation,...
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