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A new anabolic compound, LLP2A-Ale, reserves periodontal bone loss in mice through augmentation of bone formation
BackgroundCurrently, there are no effective medications to reverse periodontal disease (PD)-induced bone loss. The objective of this study was to...
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Development of a PVA/PCL/CS-Based Nanofibrous Membrane for Guided Tissue Regeneration and Controlled Delivery of Doxycycline Hydrochloride in Management of Periodontitis: In Vivo Evaluation in Rats
Antibiotic administration is an adjacent therapy to guided tissue regeneration (GTR) in the management of periodontitis. This is due to the major...
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UPR attenuates the proinflammatory effect of HPDLF on macrophage polarization
Human periodontal ligament fibroblast (HPDLF) is a major component of the resident cells in the periodontal microenvironment, and plays important...
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Prospective clinical investigations of children with periodontal Ehlers–Danlos syndrome identify generalized lack of attached gingiva as a pathognomonic feature
PurposeWe report prospective clinical investigations of children affected with periodontal Ehlers–Danlos syndrome (pEDS). The main clinical features...
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Galla Turcica alleviates gingiva inflammation and alveolar bone resorption via regulating Th1/Th17 in a mouse model of periodontitis
It establishes that inflammatory disorder of Th1 and Th17 cells promotes alveolar bone damage during periodontitis. It is proved that Galla Turcica...
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Improved osteogenic differentiation by extremely low electromagnetic field exposure: possible application for bone engineering
Human periodontal ligament mesenchymal stem cells (hPDLSCs) are a promising cell type model for regenerative medicine applications due to their...
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Role of noncoding RNAs in orthodontic tooth movement: new insights into periodontium remodeling
Orthodontic tooth movement (OTM) is biologically based on the spatiotemporal remodeling process in periodontium, the mechanisms of which remain...
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Optimization of In Situ Gel-Forming Chlorhexidine-Encapsulated Polymeric Nanoparticles Using Design of Experiment for Periodontitis
Periodontitis is a chronic inflammatory disease of the gums caused by pathogenic microorganisms damaging and destroying periodontal tissues....
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TRPV1 Regulates Proinflammatory Properties of M1 Macrophages in Periodontitis Via NRF2
Periodontitis, characterized by progressive alveolar bone destruction, leads to the loss of attachment and stability of the affected teeth....
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METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis
BackgroundPeriodontitis is a highly prevalent oral disease characterized by bacterium-induced periodontal inflammation and alveolar bone destruction....
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Polarization Profiles of T Lymphocytes and Macrophages Responses in Periodontitis
Periodontitis is a multifactorial, chronic inflammatory disease affecting the supporting structures of teeth triggered by the complex interactions...
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Sudachitin Inhibits Matrix Metalloproteinase-1 and -3 Production in Tumor Necrosis Factor-α-Stimulated Human Periodontal Ligament Cells
Sudachitin, a polymethoxylated flavonoid found in the skin of Citrus sudachi , is a biologically active substance. The aim of this study was to...
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Disorders of the Biochemical Composition of the Periodontium in Rats with Periodontitis and Chronic Pain Syndrome
We analyzed the composition of the periodontal tissue in rats with experimental periodontitis and chronic pain syndrome. Chronic pain syndrome was...
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Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase
The treatment of chronic inflammation with systemically administered anti-inflammatory treatments is associated with moderate-to-severe side effects,...
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Aggregatibacter actinomycetemcomitans: From Basic to Advanced Research
Aggregatibacter actinomycetemcomitans is a major periodontal pathogen that was identified firstly in actinomycotic lesions and later in advanced...
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γδ T cells in oral diseases
Objectiveγδ T cells are a distinct subset of unconventional T cells, which link innate and adaptive immunity by secreting cytokines and interacting...
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Natural polyphenol self-assembled pH-responsive nanoparticles loaded into reversible hydrogel to inhibit oral bacterial activity
Periodontitis is one of the most prevalent chronic inflammatory diseases and Polyphenols isolated from Turkish gall play a major role in the...
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Antibacterial-Anti-Inflammatory-Bone Restoration Procedure Achieved by MIN-Loaded PLGA Microsphere for Efficient Treatment of Periodontitis
The main development process of periodontitis involves periodontal pathogenic bacteria as the initiating factor causing the onset of destructive...
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Advanced glycation end products impair bone marrow mesenchymal stem cells osteogenesis in periodontitis with diabetes via FTO-mediated N6-methyladenosine modification of sclerostin
BackgroundDiabetes mellitus (DM) and periodontitis are two prevalent diseases with mutual influence. Accumulation of advanced glycation end products...
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Coffee consumption and periodontitis: a Mendelian Randomization study
BackgroundCoffee is one of the most consumed beverages in the world, coffee consumption has been growing in the United States over the past 20 years....
