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Relation of Promoter Methylation of the Oxytocin Gene to Stressful Life Events and Depression Severity
Oxytocin (OT) is a neuropeptide associated with trauma, sociality, and depression. Despite the widely accepted assumption of OT playing a role in the...
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The future of rodent models in depression research
Currently, over 300 million people worldwide have depression, and the socioeconomic burden of this debilitating disorder is anticipated to increase...
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Early Life Stress and DNA Methylation
DNA methylation and demethylation can be influenced by several environmental factors including diet, smoking, drug consumption, parental behavior and...
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Women’s Psychiatry
Brain disorders and mental diseases, in particular, are common and considered as a top global health challenge for the twenty-first century....
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Parental Behavior
Maternal behavior (MB) in mammals is a goal-directed behavior adapted for ensuring the survival of a female’s offspring. It includes a constellation...
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Risk Factors and Prevention Strategies for Anxiety Disorders in Childhood and Adolescence
Anxiety is prevalent in childhood and adolescence. Youth with maladaptive responses to common situations and stressors are at risk of having anxiety...
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Translating insights from neuropsychiatric genetics and genomics for precision psychiatry
The primary aim of precision medicine is to tailor healthcare more closely to the needs of individual patients. This requires progress in two areas:...
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Pharmacological Targets and Mechanisms of Action of Antipsychotic Substances in the Context of the Neurochemical Theory of the Pathogenesis of Schizophrenia
Schizophrenia is characterized by neurochemical, morphological, bioelectrical, and behavioral changes in the body, which overall produce a system of...
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White matter microstructure in women with acute and remitted anorexia nervosa: an exploratory neuroimaging study
Anorexia nervosa (AN) is a highly heritable psychiatric disorder characterized by starvation and emaciation and associated with changes in brain...
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DNA Methylation and Hydroxymethylation and Behavior
Environmentally sensitive molecular mechanisms in the brain, such as DNA methylation, have become a significant focus of neuroscience research...
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Hormonal and Behavioral Characteristics of Prenatally Stressed Female Rats in an Experimental Model of Depression
Changes in behavior and hypothalamo-hypophyseal-adrenal system (HHAC) activity were studied in adult prenatally stressed female rats in an...
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SRF and SRFΔ5 Splicing Isoform Recruit Corepressor LSD1/KDM1A Modifying Structural Neuroplasticity and Environmental Stress Response
Ten to 20% of western countries population suffers from major depression disorder (MDD). Stressful life events represent the main environmental risk...
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Prenatal maternal antidepressants, anxiety, and depression and offspring DNA methylation: epigenome-wide associations at birth and persistence into early childhood
BackgroundMaternal mood disorders and their treatment during pregnancy may have effects on the offspring epigenome. We aim to evaluate associations...
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Parental Behavior
Maternal behavior (MB) in mammals is a goal-directed behavior adapted for ensuring the survival of a female’s offspring. It includes a constellation...
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The Role of Aberrations in the Immune-Inflammatory Response System (IRS) and the Compensatory Immune-Regulatory Reflex System (CIRS) in Different Phenotypes of Schizophrenia: the IRS-CIRS Theory of Schizophrenia
Several lines of evidence indicate that aberrations in immune-inflammatory pathways may contribute to the pathophysiology of schizophrenia spectrum...
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Exploring the effect of antenatal depression treatment on children’s epigenetic profiles: findings from a pilot randomized controlled trial
BackgroundChildren prenatally exposed to maternal depression more often show behavioral and emotional problems compared to unexposed children,...
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Prenatal Stress and Neurodevelopmental Plasticity: Relevance to Psychopathology
Prenatal development constitutes a critical time for sha** adult behaviour and may set the stage for vulnerability to disease later in life. A...
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Review of Schizophrenia Research Using MEG
Schizophrenia is a severe form of mental illness characterized by hallucinations, delusions, changes in affect, and serious cognitive and social...
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Quantification of the Biological Age of the Brain Using Neuroimaging
The cosmetic and behavioural aspects of ageing become increasingly apparent with the passing years. The individual variability in physical ageing can...
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Early-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge?
Accumulating evidence suggests that adversities at critical periods in early life, both pre- and postnatal, can lead to neuroendocrine perturbations,...
