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The HLA ligandome of oropharyngeal squamous cell carcinomas reveals shared tumour-exclusive peptides for semi-personalised vaccination
BackgroundThe immune peptidome of OPSCC has not previously been studied. Cancer-antigen specific vaccination may improve clinical outcome and...
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Structural insights into somatostatin receptor 5 bound with cyclic peptides
Somatostatin receptor 5 (SSTR5) is highly expressed in ACTH-secreting pituitary adenomas and is an important drug target for the treatment of...
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Collagen-binding peptides for the enhanced imaging, lubrication and regeneration of osteoarthritic articular cartilage
Treatments for osteoarthritis would benefit from the enhanced visualization of injured articular cartilage and from the targeted delivery of...
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Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer
BackgroundImmunotherapy based on checkpoint inhibitors is highly effective in mismatch repair deficient (MMRd) colorectal cancer (CRC). These tumors...
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Peptides and Their Delivery to the Brain
There has been great progress in utilizing peptides as therapeutic agents in clinical settings. More than 500 peptides are being investigated in...
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Designing High Binding Affinity Peptides for MHC Class I Using MAM: An In Silico Approach
The availability of extensive MHC-peptide binding data has boosted machine learning-based approaches for predicting binding affinity and identifying...
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Effect of Short Peptides of Pregnancy-Specific β1-Glycoprotein on Differentiation of Human Regulatory T Cells In Vitro and on Their Cytokine Profile
Pregnancy-specific β1-glycoprotein (PSG), one of the most important proteins of pregnancy, has a pronounced immunosuppressive effect. Short peptides...
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Challenges and Strategies to Enhance the Systemic Absorption of Inhaled Peptides and Proteins
Proteins and peptides-based therapeutics are making substantial access to the market due to their obvious advantages of strong potency, high...
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Human Hepatic Transporter Signature Peptides for Quantitative Targeted Absolute Proteomics: Selection, Digestion Efficiency, and Peptide Stability
PurposeQuantitative targeted absolute proteomics (QTAP) quantifies proteins by measuring the signature peptides produced from target proteins by...
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Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway
The tumor-elicited inflammation is closely related to tumor microenvironment during tumor progression. S100A8 , an endogenous ligand of Toll-like...
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Urinary peptides provide information about the risk of mortality across a spectrum of diseases and scenarios
BackgroundThere is evidence of pre-established vulnerability in individuals that increases the risk of their progression to severe disease or death,...
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Aqueous remote loading of model cationic peptides in uncapped poly(lactide-co-glycolide) microspheres for long-term controlled release
Remote loading microencapsulation of peptides into polymer microspheres without organic solvent represents a promising alternative to develop...
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Investigating the role of peptides in effective therapies against cancer
Early diagnosis and effective treatment of cancer are challenging. To diagnose and treat cancer effectively and to overcome these challenges,...
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T cell independent antibody responses with class switch and memory using peptides anchored on liposomes
Vaccines generally require T lymphocytes for B-cell activation and immunoglobulin class switching in response to peptide or protein antigens. In the...
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Mass spectrometric analysis of chondroitin sulfate-linked peptides
Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix components composed of linear glycosaminoglycan (GAG) side chains attached to a...
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Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions
Short half-lives in circulation and poor transport across the blood–brain barrier limit the utility of cytokines and growth factors acting as...
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Two peptides derivate from Acinetobacter baumannii outer membrane protein K as vaccine candidates: a comprehensive in silico study
BackgroundThe lack of appropriate vaccines is an obstacle to the effective management of A. baumannii infections. Peptide vaccines offer an...
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Functionalized zein nanoparticles targeting neonatal Fc receptor to enhance lung absorption of peptides
Peptides have a distinguished therapeutic potential for several chronic conditions, and more than 80 peptides exist in the global market. However,...
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Differential regulation of progranulin derived granulin peptides
BackgroundHaploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). PGRN is comprised of 7.5 granulin...
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Flagellin conjugated Per a 10 and its T cell peptides attenuate airway inflammation and restore cellular function
Adjuvants were used to modulate response towards relevant immune cells. The present study aims to investigate FlaA-conjugated Per a 10 and T cell...
