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Repeated cold-water immersion improves autonomic cardiac modulation following five sessions of high-intensity interval exercise
PurposeThe study aimed to investigate the effect of repeated cold-water immersion (CWI) after high-intensity interval exercise sessions on...
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Analyzing Long-Term Changes in Soundscapes Using Power Spectral Band Sums
Various species of fish make sounds (individually and in choruses) while mating and for aggressive encounters. Recording the sounds of fishes in...
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Coenzyme Q10 and exercise training reinstate middle cerebral artery occlusion-induced behavioral deficits and hippocampal long-term potentiation suppression in aging rats
RationalPatients experience post-stroke cognitive impairment during aging. To date, no specific treatment solution has been reported for this...
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Efficacy of water spray for evaporative cooling in athletes with spinal cord injury
Study designInterventional crossover study.
ObjectiveSpinal cord injury (SCI) disrupts afferent input to the hypothalamus and impairs efferent vaso-...
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Immunization against arthropod protein impairs transmission of rickettsial pathogen from ticks to the vertebrate host
Human anaplasmosis caused by Anaplasma phagocytophilum is one of the most common tick-borne diseases in the United States. The black-legged ticks, Ixod...
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Metformin mitigates amyloid β1-40-induced cognitive decline via attenuation of oxidative/nitrosative stress and neuroinflammation
Metformin is an antidiabetic medicine widely used for management of type 2 diabetes with neuroprotective effects and promising potential to attenuate...
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Temporal and spatial summation of laser heat stimuli in cultured nociceptive neurons of the rat
We studied the efficacy of a near-infrared laser (1475 nm) to activate rat dorsal root ganglion (DRG) neurons with short punctate radiant heat pulses...
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Natural Polymers-Based Nanoparticles Targeted to Solid Tumors
Natural polymers have been extensively explored as carriers for encapsulation and delivery of drugs and other bioactive molecules. Natural polymers...
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Independent and combined impact of hypoxia and acute inorganic nitrate ingestion on thermoregulatory responses to the cold
PurposeThis study assessed the impact of normobaric hypoxia and acute nitrate ingestion on shivering thermogenesis, cutaneous vascular control, and...
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Beneficial effects of levetiracetam in streptozotocin-induced rat model of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common neurodegenerative disorder among the elderly. In the light of increasing AD prevalence and lack of...
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Autonomic thermoregulatory responses and subjective thermal perceptions upon the initiation of thermal behavior among resting humans in hot and humid environment
BackgroundWhile thermoregulatory behavior is critical for maintaining homeostasis, our knowledge of behavioral thermoeffectors in humid heat is...
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Applications of Microfluidics
Microfluidics as a field has a plethora of applications in several fields. From heat transfer to biomedical applications, microfluidic techniques are...
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Paeonol Ameliorates Cuprizone-Induced Hippocampal Demyelination and Cognitive Deficits through Inhibition of Oxidative and Inflammatory Events
Multiple sclerosis (MS) is a chronic and inflammatory disorder of the central nervous system with autoimmune nature that is typified by varying...
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Characterization of Freezing Processes in Drug Substance Bottles by Ice Core Sampling
Freezing of biological drug substance (DS) is a critical unit operation that may impact product quality, potentially leading to protein aggregation...
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A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 1: Foundational principles and theories of regulation
This contribution is the first of a four-part, historical series encompassing foundational principles, mechanistic hypotheses and supported facts...
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Nobiletin prevents amyloid β1-40-induced cognitive impairment via inhibition of neuroinflammation and oxidative/nitrosative stress
Alzheimer’s disease (AD) is presented as an age-related neurodegenerative disease with multiple cognitive deficits and amyloid β (Aβ) accumulation is...
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Paeonol Ameliorates Cognitive Deficits in Streptozotocin Murine Model of Sporadic Alzheimer’s Disease via Attenuation of Oxidative Stress, Inflammation, and Mitochondrial Dysfunction
Intracerebroventricular (ICV) microinjection of diabetogenic drug streptozotocin (STZ) in rodents consistently produces a model of sporadic...
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Fabrication of Polymeric Microneedles using Novel Vacuum Compression Molding Technique for Transdermal Drug Delivery
PurposeTo demonstrate the feasibility of vacuum compression molding as a novel technique for fabricating polymeric poly (D, L-lactic-co-glycolic...
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Topical and Transdermal Drug Delivery
This chapter reviews numerous concepts relevant to drug delivery topically and transdermally. Topics covered include the skin’s function barrier,...
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Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats
Hypothyroidism has been reported to be associated with cognitive decline. Considering the role of folic acid (FA) in cognitive performance, the...
