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Dopaminergic and Adrenergic Pathways as Targets for Drug Repurposing in the Neuroimmune Network
Dopamine, noradrenaline and adrenaline are catecholamines, and are all produced along the same metabolic pathway. Their discovery dates back to the...
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The Kraepelin Model
Since antiquity, the mental disorders of melancholia, mania, and hereditary insanity had been recognised, but not dementia praecox (now...
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Neuroimmune Interactions and Their Role in Carcinogenesis
The interaction between the nervous and immune systems in response to stressful events (i.e., the fight-or-flight response) has been established for...
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Diabetes and Neurological Disorder
Neurologic issues usually accompany diabetes mellitus, which can be incapacitating. Diabetic patients may have discomfort and sensory anomalies,...
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High Frequency of Autoantibodies in COVID-19 Patients with Central Nervous System Complications: a Multicenter Observational Study
We present a panel of central nervous system (CNS) complications associated with coronavirus disease 2019 (COVID-19) and their clinical...
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Markers of Inflammation, Energy and Glutamate Metabolism, and Antioxidant Defense in Patients with Adolescent Depression
Abstract —The involvement of inflammation, disturbances of glutamate metabolism, and oxidative stress in the pathogenesis of schizophrenia and...
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The Central Effects of Peripherally Administered Immune Cells Modulated by an Original Anticonvulsant in Experimental Alcoholism
Abstract —Disruption of neuroimmune regulatory relationships caused by a change in the functional phenotype of immune cells due to chronic ethanol...
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The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes
The gastrointestinal tract is densely innervated by a complex network of neurons that coordinate critical physiological functions. Here, we summarize...
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REPIMPACT - a prospective longitudinal multisite study on the effects of repetitive head impacts in youth soccer
Repetitive head impacts (RHI) are common in youth athletes participating in contact sports. RHI differ from concussions; they are considered hits to...
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The Fifth Bioelectronic Medicine Summit: today’s tools, tomorrow’s therapies
The emerging field of bioelectronic medicine (BEM) is poised to make a significant impact on the treatment of several neurological and inflammatory...
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Elevated blood and cerebrospinal fluid biomarkers of microglial activation and blood‒brain barrier disruption in anti-NMDA receptor encephalitis
BackgroundAnti-NMDA receptor (NMDAR) encephalitis is an autoimmune disease characterized by complex neuropsychiatric syndrome and cerebrospinal fluid...
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Roles of Macrophages and Their Interactions with Schwann Cells After Peripheral Nerve Injury
The adult peripheral nervous system has a significant ability for regeneration compared to the central nervous system. This is related to the unique...
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Age-dependent favorable visual recovery despite significant retinal atrophy in pediatric MOGAD: how much retina do you really need to see well?
BackgroundTo investigate age-related severity, patterns of retinal structural damage, and functional visual recovery in pediatric and adult cohorts...
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Clinical-Immunological Correlates in Post-COVID-19 Endogenous Psychoses
Objectives . To carry out a clinical and immunological study of the potential impact of coronavirus infection on the course of endogenous psychoses. Mat...
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Optogenetic stimulation of basal forebrain cholinergic neurons prevents neuroinflammation and neuropsychiatric manifestations in pristane induced lupus mice
BackgroundNeuroinflammation has been identified as one of the primary pathogenic factors of neuropsychiatric systemic lupus erythematosus (NPSLE)....
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Neuroendocrine-immune Interactions in Major Depressive Disorder: Glucocorticoids and Glucocorticoid Receptors
Major depressive disorder is a leading cause of disability worldwide; therefore, effective treatment options are crucial. However, due to the highly...