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“Reversed polarization” of Na/K-ATPase—a sign of inverted transport in the human endolymphatic sac: a super-resolution structured illumination microscopy (SR-SIM) study
The human endolymphatic sac (ES) is believed to regulate inner ear fluid homeostasis and to be associated with Meniere’s disease (MD). We analyzed...
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A Functional Interaction Between Na,K-ATPase β2-Subunit/AMOG and NF2/Merlin Regulates Growth Factor Signaling in Cerebellar Granule Cells
The Na,K-ATPase, consisting of a catalytic α-subunit and a regulatory β-subunit, is a ubiquitously expressed ion pump that carries out the transport...
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Energy optimisation predicts the capacity of ion buffering in the brain
Neurons store energy in the ionic concentration gradients they build across their cell membrane. The amount of energy stored, and hence the work the...
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Diversity, Mechanism, and Optogenetic Application of Light-Driven Ion Pump Rhodopsins
Ion-transporting microbial rhodopsins are widely used as major molecular tools in optogenetics. They are categorized into light-gated ion channels...
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Selective SERCA2a activator as a candidate for chronic heart failure therapy
BackgroundThe sarcoplasmic reticulum (SR) Ca 2+ ATPase (SERCA2a) depression substantially contributes to diastolic dysfunction in heart failure (HF),...
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M-wave changes caused by brief voluntary and stimulated isometric contractions
IntroductionUnder isometric conditions, the increase in muscle force is accompanied by a reduction in the fibers’ length. The effects of muscle...
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Changes in Inflammatory Response, Redox Status and Na+, K+-ATPase Activity in Primary Astrocyte Cultures from Female Wistar Rats Subject to Ovariectomy
Astrocytes are dynamic glial cells that maintain brain homeostasis, particularly metabolic functions, inflammatory response, and antioxidant defense....
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The ESCRT-III molecules regulate the apical targeting of bile salt export pump
BackgroundThe bile salt export pump (BSEP) is a pivotal apical/canalicular bile salt transporter in hepatocytes that drives the bile flow. Defects in...
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Resting membrane state as an interplay of electrogenic transporters with various pumps
In this study, a new idea that electrogenic transporters determine cell resting state is presented. The previous assumption was that pumps,...
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Rejuvenating the Potential of Antimicrobials Via Targeted Therapy of Efflux Pumps: The Advent of Phytotherapeutics
Antimicrobial resistance (AMR) and the emergence of multidrug-resistant organisms are one of the most eminent impediments of recent times. The...
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Very low-calorie ketogenic diet (VLCKD): an antihypertensive nutritional approach
BackgroundObesity is accompanied by hormonal, inflammatory and endothelial alterations. These alterations induce a stimulation of several other...
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Efflux pump activity, biofilm formation and antibiotic resistance profile of Klebsiella spp. isolated from clinical samples at Lagos University Teaching Hospital
ObjectiveNosocomial and community acquired multidrug resistant Klebsiella infections are wide spread resulting in high morbidity and mortality due...
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Kalium channelrhodopsins are natural light-gated potassium channels that mediate optogenetic inhibition
Channelrhodopsins are used widely for optical control of neurons, in which they generate photoinduced proton, sodium or chloride influx. Potassium (K + ...
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Concomitant Treatment with Proton Pump Inhibitors and Cephalosporins Does Not Enhance QT-Associated Proarrhythmia in Isolated Rabbit Hearts
Recent results from data mining analyses and reports of adverse drug events suggest a QT-prolonging drug–drug interaction resulting from the...
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Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure
BackgroundDisturbances in the brain fluid balance can lead to life-threatening elevation in the intracranial pressure (ICP), which represents a vast...
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Purple pitanga extract (Eugenia uniflora) attenuates oxidative stress induced by MPTP
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been widely used due to its specific and reproducible neurotoxic effect on the nigrostriatal...
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ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy
Despite advancements in treating metastatic melanoma, many patients exhibit resistance to targeted therapies. Our study focuses on ATP1A1, a sodium...
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Theory of Excitability
Essential for membrane excitability is the action potential. The generation and propagation is based on the Hodgkin–Huxley description, which shall...
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Blueberry Extract Modulates Brain Enzymes Activities and Reduces Neuroinflammation: Promising Effect on Lipopolysaccharide-Induced Depressive-Like Behavior
Major depressive disorder (MDD) is one of the most common neuropsychiatric disorders with high rates of prevalence and mortality. MDD is...
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Possible Antinociceptive Mechanisms Triggered by Nanomolar Ouabain Concentrations in Primary Sensory Neurons
The responses of primary sensory neurons to subnanomolar and nanomolar ouabain concentrations, corresponding to the endogenous ouabain (EO)...