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Circulating miRNAs in extracellular vesicles related to treatment response in patients with idiopathic membranous nephropathy
BackgroundExtracellular vesicle (EV)-microRNAs (miRNAs) are potential biomarkers for various renal diseases. This study attempted to identify the...
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Identification of invasion-metastasis associated MiRNAs in gallbladder cancer by bioinformatics and experimental validation
BackgroundRecent studies exploring the roles of invasion-metastasis associated miRNAs in gallbladder cancer (GBC) are limited. In the study, we aimed...
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Role of miRNAs in diabetic neuropathy: mechanisms and possible interventions
Accelerating cases of diabetes worldwide have given rise to higher incidences of diabetic complications. MiRNAs, a much-explored class of non-coding...
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The Role of lncRNAs and miRNAs in Therapy-Induced Senescence in Neuroblastoma
Purpose of ReviewNeuroblastoma, a paediatric malignancy of the sympathoadrenal lineage with a variable clinical course, is the most prevalent...
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Techniques for Characterizing Cytomegalovirus-Encoded miRNAs
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level by binding to sites within the 3′...
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A liquid biopsy signature of circulating exosome-derived mRNAs, miRNAs and lncRNAs predict therapeutic efficacy to neoadjuvant chemotherapy in patients with advanced gastric cancer
At present, there is no validated marker to identify the subpopulation of patients with advanced gastric cancer (AGC) who might benefit from...
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From inflammatory bowel disease to colorectal cancer: what’s the role of miRNAs?
Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods. Ulcerative colitis and Crohn’s disease are two...
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Mesenchymal stem cell (MSC)-derived exosomes as novel vehicles for delivery of miRNAs in cancer therapy
Mesenchymal stem cells (MSCs) are known as promising sources for cancer therapy and can be utilized as vehicles in cancer gene therapy. MSC-derived...
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Real-Time Quantitative PCR and Fluorescence In Situ Hybridization for Subcellular Localization of miRNAs in Neurons
Neuronal miRNAs play major roles in regulation of synaptic development and plasticity. The small size of miRNAs and, in some cases, their low level...
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Multiplex Analysis of Cerebrospinal Fluid and Serum Exosomes MicroRNAs of Untreated Relapsing Remitting Multiple Sclerosis (RRMS) and Proposing Noninvasive Diagnostic Biomarkers
Exosomal microRNAs (miRNAs) are emerging diagnostic biomarkers for neurodegenerative diseases. In this study, we aimed to detect relapsing–remitting...
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Analysis of miRNA Expression from the DLK1-DIO3 Locus in CD4+ and CD14+ Cells in Relapsing-Remitting Multiple Sclerosis
Objectives. To analyze the expression of several previously unstudied miRNAs from the DLK1-DIO3 locus in blood mononuclear cells (PBMC) and their CD14
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Alteration of miRNAs in Small Neuron-Derived Extracellular Vesicles of Alzheimer's Disease Patients and the Effect of Extracellular Vesicles on Microglial Immune Responses
Alzheimer ' s disease (AD) is one of the most severe neurodegenerative diseases observed in the elderly population. Although the hallmarks of AD have...
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Cancer-associated miRNAs and their therapeutic potential
MicroRNA (miRNA; miR) is a functionally small non-coding RNA and can negatively regulate gene expression by directly binding to the target gene. Some...
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The selective sponging of miRNAs by OIP5-AS1 regulates metabolic reprogramming of pyruvate in adenoma-carcinoma transition of human colorectal cancer
RNA interactomes and their diversified functionalities have recently benefited from critical methodological advances leading to a paradigm shift from...
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Potential of miRNAs in urinary extracellular vesicles for management of active surveillance in prostate cancer patients
BackgroundActive surveillance is an alternative to radical treatment for patients with low-risk prostate cancer, which could also benefit some...
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Extracellular vesicle-associated miRNAs are an adaptive response to gestational diabetes mellitus
BackgroundGestational diabetes mellitus (GDM) is a serious public health issue affecting 9–15% of all pregnancies worldwide. Recently, it has been...
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Whole-transcriptome sequencing identifies key mRNAs, miRNAs, lncRNAs, and circRNAs associated with unexplained recurrent pregnancy loss
Recurrent pregnancy loss is a common obstetric complication affecting approximately 1–2% of reproductive population worldwide, but the precise causes...
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Urinary Exosomal miRNAs as biomarkers of bladder Cancer and experimental verification of mechanism of miR-93-5p in bladder Cancer
BackgroundBladder cancer (BC) is one of the most common malignancies globally. Early diagnosis of it can significantly improve patients’ survival and...
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Expression profiling of exosomal miRNAs derived from different stages of infection in mice infected with Echinococcus granulosus protoscoleces using high-throughput sequencing
Echinococcosis is a worldwide zoonosis. The mechanism of the establishment, growth, and persistence of parasites in the host has not been fully...
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miRNAs as Therapeutic Target in Obesity and Cancer
MicroRNAs are small non-coding RNAs that regulate the expression of many genes. Alteration of microRNA expressions is associated with the occurrence...