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Physicochemical characterization and genotoxicity of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities
BackgroundCarbon nanotubes and nanofibers (CNT/F) have known toxicity but simultaneous comparative studies of the broad material class, especially...
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Somatic Cell Alterations in Interespecific Hybrids of Cenchrus purpureum (Schumach.) and Cenchrus americanus (L.) Morrone by Genomic in Situ Hybridization
AbstractThe cross between Cenchrus purpureum (Schumach.) (Napier grass) and Cenchrus americanus (L.) Morrone (pearl millet) produce triploid and...
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The cGAS/STING/TBK1/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels
Chromosomal instability (CIN) in cancer cells has been reported to activate the cGAS–STING innate immunity pathway via micronuclei formation, thus...
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Cytogenetic Effects of Carbendazim on Mouse Bone Marrow Cells
AbstractA study of the genotoxic activity of fungicide carbendazim was carried out. It was demonstrated that the tested technical grade active...
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Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements
Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. Based on large-scale DNA sequencing of human tumours, the...
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AP4 suppresses DNA damage, chromosomal instability and senescence via inducing MDC1/Mediator of DNA damage Checkpoint 1 and repressing MIR22HG/miR-22-3p
BackgroundAP4 (TFAP4) encodes a basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor and is a direct target gene of the oncogenic...
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Study of the DNA Damage in Peripheral Blood Lymphocytes Using Micronucleus Test in Residents of the Techa Riverside Villages Who Were Chronically Exposed in Utero and Postnatally
AbstractThe paper presents the results of the assessment of the frequency of the peripheral blood Т lymphocytes with micronuclei in Techa riverside...
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Methods of Detection and Mechanisms of Origin of Complex Structural Genome Variations
Based on classical karyoty**, structural genome variations (SVs) have generally been considered to be either “simple” (with one or two breakpoints)...
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A missense variant in NUF2, a component of the kinetochore NDC80 complex, causes impaired chromosome segregation and aneuploidy associated with microcephaly and short stature
Mutations in proteins involved in cell division and chromosome segregation, such as microtubule-regulating, centrosomal and kinetochore proteins, are...
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The role of genetic polymorphisms for inducing genotoxicity in workers occupationally exposed to benzene: a systematic review
Benzene is used worldwide as a major raw material in a number of industrial processes and also a potent airborne pollutant emitted from traffic...
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Genetic Toxicology Studies
Genetic toxicology is a sub-discipline of toxicology dealing with the potential of compounds to cause damage to the genetic material,...
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cGAS Mediates the Inflammatory Responses of Human Microglial Cells to Genotoxic DNA Damage
Genomic instability is a key driving force for the development and progression of many age-related neurodegenerative diseases and central nervous...
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Identification of the cytoplasmic DNA-Sensing cGAS-STING pathway-mediated gene signatures and molecular subtypes in prostate cancer
BackgroundConsidering the age relevance of prostate cancer (PCa) and the involvement of the cGAS-STING pathway in aging and cancer, we aim to...
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DNA replication stress and mitotic catastrophe mediate sotorasib addiction in KRASG12C-mutant cancer
BackgroundSotorasib is the first KRAS G12C inhibitor approved by the US Food and Drug Administration for treating KRAS G12C -mutant non-small-cell lung...
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Effect of the THBS1 Gene Knockout on the Radiation-Induced Cellular Response in a Model System In Vitro
AbstractIn this study, the effect of the THBS1 gene knockout on the survival of human tumor cells, the frequency of spontaneous and...
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Single-Cell MTT: A Simple and Sensitive Assay for Determining the Viability and Metabolic Activity of Polyploid Giant Cancer Cells (PGCCs)
Solid tumors and tumor-derived cell lines commonly contain highly enlarged (giant) cancer cells that enter a state of transient dormancy (active...