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Animal Models for Bone Metastasis Study
Cancer-mediated death is promoted by the process of metastasis. Often, bone is the preferred site of metastasis. The process of metastasis at the...
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Linking cell mechanical memory and cancer metastasis
Metastasis causes most cancer-related deaths; however, the efficacy of anti-metastatic drugs is limited by incomplete understanding of the biological...
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Platelets induce CD39 expression in tumor cells to facilitate tumor metastasis
BackgroundTumor cells continue to evolve the metastatic potential in response to signals provided by the external microenvironment during metastasis....
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High-fat diet promotes prostate cancer metastasis via RPS27
BackgroundMetastasis is the leading cause of death among prostate cancer (PCa) patients. Obesity is associated with both PCa-specific and all-cause...
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Melanoma with Brain Metastasis
Melanoma is the third most common skin malignancy but is the one with the highest propensity to metastasize, potentially able to disseminate to any...
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Dissecting metastasis using preclinical models and methods
Metastasis has long been understood to lead to the overwhelming majority of cancer-related deaths. However, our understanding of the metastatic...
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Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis
BackgroundMetastasis accounts for the majority of cancer-related deaths. Actin dynamics and actin-based cell migration and invasion are important...
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An essential gene signature of breast cancer metastasis reveals targetable pathways
BackgroundThe differential gene expression profile of metastatic versus primary breast tumors represents an avenue for discovering new or...
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Biomarkers in Tumor Recurrence and Metastasis
Biomolecules that are produced or secreted by tumor cells themselves or in response to tumor by other cells of body are cancer biomarkers that...
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Chemotherapy-induced metastasis: molecular mechanisms and clinical therapies
Chemotherapy, the most widely accepted treatment for malignant tumors, is dependent on cell death induced by various drugs including antimetabolites,...
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DPY30 promotes colorectal carcinoma metastasis by upregulating ZEB1 transcriptional expression
DPY30 belongs to the core subunit of components of the histone lysine methyltransferase complex, which is implicated in tumorigenesis, cell...
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Metastasis organotropism in colorectal cancer: advancing toward innovative therapies
Distant metastasis remains a leading cause of mortality among patients with colorectal cancer (CRC). Organotropism, referring to the propensity of...
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Metastasis suppressor genes and their role in the tumor microenvironment
The metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells at metastatic sites. Within...
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MiRNA-related metastasis in oral cancer: moving and shaking
Across the world, oral cancer is a prevalent tumor. Over the years, both its mortality and incidence have grown. Oral cancer metastasis is a complex...
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TSPAN1 inhibits metastasis of nasopharyngeal carcinoma via suppressing NF-kB signaling
Nasopharyngeal carcinoma (NPC) originates in the epithelial cells of the nasopharynx and is a common malignant tumor in southern China and Southeast...
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Dissecting the MUC5AC/ANXA2 signaling axis: implications for brain metastasis in lung adenocarcinoma
Non-small cell lung carcinoma (NSCLC) exhibits a heightened propensity for brain metastasis, posing a significant clinical challenge. Mucin 5ac...
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Cancer metastasis through the lymphatic versus blood vessels
Whether cancer cells metastasize from the primary site to the distant sites via the lymphatic vessels or the blood vessels directly into the...
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TFEB: a double-edged sword for tumor metastasis
Transcription factor EB, a member of the microphthalmia-associated transcription factor (MiTF/TFE) family, is a master regulator of autophagy,...
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RAGE inhibitor TTP488 (Azeliragon) suppresses metastasis in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a highly aggressive and metastatic cancer subtype, which is generally untreatable once it metastasizes. We...
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Immune characteristics associated with lymph node metastasis in early-stage NSCLC
PurposeTumor metastasis significantly impacts the prognosis of non-small cell lung cancer (NSCLC) patients, with lymph node (LN) metastasis being the...
