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Cell-to-Cell Crosstalk: A New Insight into Pulmonary Hypertension
Pulmonary hypertension (PH) is a disease with high pulmonary arterial pressure, pulmonary vasoconstriction, pulmonary vascular remodeling, and...
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Extracellular Matrix as a Metabolic Niche in Cancer
Heterogeneity in tumor mass with an altered tumor microenvironment is a hallmark of cancer metabolism, which provides a metabolic niche for cells....
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Metabolic Pathways and Cell Signaling
This chapter overviews the basic features of metabolic pathways concerning the three main classes of energetic substrates – carbohydrates, lipids and...
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Crosstalk between oxidative phosphorylation and immune escape in cancer: a new concept of therapeutic targets selection
BackgroundCancer is increasingly recognized as a metabolic disease, with evidence suggesting that oxidative phosphorylation (OXPHOS) plays a...
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Crosstalk between autophagy and microbiota in cancer progression
Autophagy is a highly conserved catabolic process seen in eukaryotes and is essentially a lysosome-dependent protein degradation pathway. The...
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The Crosstalk Between Neurons and Glia in Methamphetamine-Induced Neuroinflammation
Methamphetamine (METH), an illicit psycho-stimulant, is widely known as an addictive drug that may cause neurotoxic effects. Previous researches on...
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Crosstalk Between Abnormal Electrical Activity and Angiotensin II Cell Signaling in the Hyperglycemic Mammalian Heart
It has been well-accepted that an up-regulation of not only the systemic but also local cardiac renin angiotensin systemRenin angiotensin system...
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Role of Distinct Fat Depots in Metabolic Regulation and Pathological Implications
People suffering from obesity and associated metabolic disorders including diabetes are increasing exponentially around the world. Adipose tissue...
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An update on chronic complications of diabetes mellitus: from molecular mechanisms to therapeutic strategies with a focus on metabolic memory
Diabetes mellitus, a chronic metabolic disease, often leads to numerous chronic complications, significantly contributing to global morbidity and...
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The role of BCAA metabolism in metabolic health and disease
It has long been postulated that dietary restriction is beneficial for ensuring longevity and extending the health span of mammals, including humans....
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Spatial transcriptomics atlas reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment components in colorectal cancer
BackgroundThe tumor-promoting role of tumor microenvironment (TME) in colorectal cancer has been widely investigated in cancer biology....
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A Systemic View of Metastatic Disease: Inter-Organ Crosstalk and Therapeutic Implications
As cancer progresses, the communication and crosstalk between cancer cells and the tumor microenvironment become a key determinant of successful...
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Prospective Advances of Extracellular Vesicles Investigation in Cardiovascular and Metabolic Research
Extracellular vesicles (EVs) play an important role in cardiovascular and metabolic diseases through intercellular communication. Although there has...
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Immuno-Oncology Crosstalk and Metabolism
This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and...
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Metabolic Reprogramming and Infectious Diseases
Cellular organization is possible through metabolic processes that ensure the construction of biomass and energy supply. Central metabolic pathways...
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Crosstalk Between Cell Death and Spinal Cord Injury: Neurology and Therapy
Spinal cord injury (SCI) often leads to neurological dysfunction, and neuronal cell death is one of the main causes of neurological dysfunction....
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Metabolic regulation of tumor-associated macrophage heterogeneity: insights into the tumor microenvironment and immunotherapeutic opportunities
Tumor-associated macrophages (TAMs) are a heterogeneous population that play diverse functions in tumors. Their identity is determined not only by...
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Landscape of molecular crosstalk between SARS-CoV-2 infection and cardiovascular diseases: emphasis on mitochondrial dysfunction and immune-inflammation
BackgroundSARS-CoV-2, the pathogen of COVID-19, is a worldwide threat to human health and causes a long-term burden on the cardiovascular system....
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Metabolic subtypes and immune landscapes in esophageal squamous cell carcinoma: prognostic implications and potential for personalized therapies
BackgroundThis study aimed to identify metabolic subtypes in ESCA, explore their relationship with immune landscapes, and establish a metabolic index...
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FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis
The escalating obesity epidemic and aging population have propelled metabolic dysfunction-associated steatohepatitis (MASH) to the forefront of...
