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Downregulation of Claudin5 promotes malignant progression and radioresistance through Beclin1-mediated autophagy in esophageal squamous cell carcinoma
BackgroundEsophageal squamous cell carcinoma (ESCC) is a highly prevalent and aggressive cancer with poor treatment outcomes. Despite the critical...
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Massive digital gene expression analysis reveals different predictive profiles for immune checkpoint inhibitor therapy between adenocarcinoma and squamous cell carcinoma of advanced lung cancer
BackgroundImmune checkpoint inhibitors prolong the survival of non-small cell lung cancer (NSCLC) patients. Although it has been acknowledged that...
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Targeting histone deacetylases in head and neck squamous cell carcinoma: molecular mechanisms and therapeutic targets
The onerous health and economic burden associated with head and neck squamous cell carcinoma (HNSCC) is a global predicament. Despite the advent of...
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Tumor specificity of WNT ligands and receptors reveals universal squamous cell carcinoma oncogenes
BackgroundThe WNT signal pathway has myriad family members, which are broadly involved in embryonic development and human cancer. Over-activation of...
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The tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy
The development of head and neck squamous cell carcinoma (HNSCC) is a multi-step process, and its survival depends on a complex tumor ecosystem,...
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Prognosis of Midkine and AT1R expression in resectable head and neck squamous cell carcinoma
BackgroundResearch studies have demonstrated that Midkine (MDK) can influence the expression and activity of Renin-angiotensin system (RAS)...
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Characterization of stemness features and construction of a stemness subtype classifier to predict survival and treatment responses in lung squamous cell carcinoma
BackgroundCancer stemness has been proven to affect tumorigenesis, metastasis, and drug resistance in various cancers, including lung squamous cell...
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A preliminary study of IgG4 expression and its prognostic significance in oral squamous cell carcinoma
BackgroundIgG4, which plays a pivotal role in the progression of phenotypically diverse tumors, serves as a prognostic marker because of its...
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miR-451a was selectively sorted into exosomes and promoted the progression of esophageal squamous cell carcinoma through CAB39
Exosomes are emerging mediators of cell-cell communication, which are secreted from cells and may be delivered into recipient cells in cell...
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Identification of a cytokine-dominated immunosuppressive class in squamous cell lung carcinoma with implications for immunotherapy resistance
BackgroundImmune checkpoint blockade (ICB) therapy has revolutionized the treatment of lung squamous cell carcinoma (LUSC). However, a significant...
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ESCCPred: a machine learning model for diagnostic prediction of early esophageal squamous cell carcinoma using autoantibody profiles
BackgroundEsophageal squamous cell carcinoma (ESCC) is a deadly cancer with no clinically ideal biomarkers for early diagnosis. The objective of this...
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Switched alternative splicing events as attractive features in lung squamous cell carcinoma
BackgroundAlternative splicing (AS) plays important roles in transcriptome and proteome diversity. Its dysregulation has a close affiliation with...
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A novel pyroptosis-related lncRNA prognostic signature associated with the immune microenvironment in lung squamous cell carcinoma
BackgroundA growing body of evidence suggests that pyroptosis-related lncRNAs (PRncRNAs) are associated with the prognoses of tumor patients and...
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Low expression of PRDM5 predicts poor prognosis of esophageal squamous cell carcinoma
BackgroundThe role of the PRDM5 in esophageal squamous cell carcinoma (ESCC) has not been revealed. This study investigated the relationship between...
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USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1
BackgroundUSP51 is a deubiquitinase (DUB), that is involved in diverse cellular processes. Accumulating evidence has demonstrated that USP51...
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Polycomb repressive complex 2 and its core component EZH2: potential targeted therapeutic strategies for head and neck squamous cell carcinoma
The polycomb group (PcG) comprises a set of proteins that exert epigenetic regulatory effects and play crucial roles in diverse biological processes,...
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Comparative clinical significance and biological roles of PFKFB family members in oral squamous cell carcinoma
BackgroundCancer cells promote glycolysis, which supports rapid cell growth and proliferation. Phosphofructokinase-fructose bisphosphatases (PFKFBs),...
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Antibody-Drug Conjugates as Novel Therapeutic Agents for Non-Small Cell Lung Carcinoma with or without Alterations in Oncogenic Drivers
Antibody-drug conjugates (ADCs) are an emerging class of therapeutics for lung cancer, and several are currently in development for this malignancy....
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Autophagy and nuclear morphometry are associated with histopathologic features in esophageal squamous cell carcinoma
AbstractLess than 15% of patients with esophageal squamous cell carcinoma (ESCC) survive 5 years after diagnosis. A better understanding of the...
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Nrf2/HO-1 Alleviates Disulfiram/Copper-Induced Ferroptosis in Oral Squamous Cell Carcinoma
Accumulating evidence indicates that the disulfiram/copper complex (DSF/Cu) has been shown to have potent antitumor activity against various cancers....
