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Implications of Tumor Immune Microenvironment and Molecular Markers for Cancer Immunotherapy
The tumor immune microenvironment (TIME) of solid tumors consists of heterogeneous cell types, including immune cells (T cells, B cells, plasma...
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Overexpressed p-S6 associates with lymph node metastasis and predicts poor prognosis in non-small cell lung cancer
BackgroundRibosomal protein S6 (S6), a downstream effect media of the AKT/mTOR pathway, not only is a part of 40S small subunit of eukaryotic...
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Extracellular Vesicles as Biomarkers for Cancer
Because of the minimally invasive nature of biofluid collection, extracellular vesicles (EVs) have promising applications in the diagnosis,...
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Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis
Cholangiocarcinoma (CC) is the second most common tumor of the liver, originating from the biliary system with increasing incidence and mortality...
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Research advances and treatment perspectives of pancreatic adenosquamous carcinoma
BackgroundAs a malignant tumor, pancreatic cancer has an extremely low overall 5-year survival rate. Pancreatic adenosquamous carcinoma (PASC), a...
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Multidimensional fragmentomic profiling of cell-free DNA released from patient-derived organoids
BackgroundFragmentomics, the investigation of fragmentation patterns of cell-free DNA (cfDNA), has emerged as a promising strategy for the early...
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Dynamic change of serum CA19–9 levels in benign and malignant patients with obstructive jaundice after biliary drainage and new correction formulas
BackgroundCA19–9 is one of the most widely used tumor markers in biliary-pancreatic diseases. The measured value may not factually reflect the...
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How much do we know about the metastatic process?
Cancer cells can leave their primary sites and travel through the circulation to distant sites, where they lodge as disseminated cancer cells (DCCs),...
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Establishment of patient-derived organoids and a characterization-based drug discovery platform for treatment of pancreatic cancer
BackgroundPancreatic cancer is one of the most lethal tumors. The aim of this study is to provide an effective therapeutic discovery platform for...
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Prognostic influence of endoscopic ultrasound-guided fine needle aspiration in IPMN-derived invasive adenocarcinoma
BackgroundEndoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for mucinous cystic neoplasm of the pancreas carries a potential risk of...
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Role of Circulating MicroRNAs in Prognosis and Diagnosis of Cancers
Cancer causes a spectrum of diseases based on the nature of the human disease. The early detection of cancer is still a clinical challenge, despite...
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Circulating tumour DNA: a challenging innovation to develop “precision onco-surgery” in pancreatic adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the third leading cause of cancer-related mortality within the next decade. Management...
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Familial pancreatic cancer with PALB2 and NBN pathogenic variants: a case report
BackgroundFamily history is one of the risk factors for pancreatic cancer. It is suggested that patients with pancreatic cancer who have a familial...
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Pancreatic cancer pathology viewed in the light of evolution
One way to understand ductal adenocarcinoma of the pancreas (pancreatic cancer) is to view it as unimaginably large numbers of evolving living...
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Benign Disorders of the Breast in Pregnancy and Lactation
Benign cystic or solid lumps frequently occur in the breasts of young women, and consequently can also be seen during pregnancy Pregnancies and...
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Molecular signaling in pancreatic ductal metaplasia: emerging biomarkers for detection and intervention of early pancreatic cancer
Pancreatic ductal metaplasia (PDM) is the transformation of potentially various types of cells in the pancreas into ductal or ductal-like cells,...
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Effects of intensive physiotherapy on Quality of Life (QoL) after pancreatic cancer resection: a randomized controlled trial
BackgroundPatients have significantly lower QoL scores after pancreatic resection due to cancer in the physical and psychological domains compared to...
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Research progress on long non-coding RNAs and their roles as potential biomarkers for diagnosis and prognosis in pancreatic cancer
Pancreatic cancer is one of the main causes of tumor-related deaths worldwide because of its low morbidity but extremely high mortality, and is...
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Sortilin-induced lipid accumulation and atherogenesis are suppressed by HNF1b SUMOylation promoted by flavone of Polygonatum odoratum
This study aims to investigate the impact of hepatocyte nuclear factor 1β (HNF1b) on macrophage sortilin-mediated lipid metabolism and aortic...
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Patient-reported burden of intensified surveillance and surgery in high-risk individuals under pancreatic cancer surveillance
In high-risk individuals participating in a pancreatic cancer surveillance program, worrisome features warrant for intensified surveillance or,...
