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Infection with the enteric pathogen C. rodentium promotes islet-specific autoimmunity by activating a lymphatic route from the gut to pancreatic lymph node
In nonobese diabetic (NOD) mice, C. rodentium promotes priming of islet-specific T-cells in pancreatic lymph nodes (PaLN), which is a critical step...
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Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs
Poor aqueous solubility of new chemical entities presents various challenges in the development of effective drug delivery systems for various...
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Injection pressure levels for creating blebs during subretinal gene therapy
Retinal damage has been associated with increased injection pressure during subretinal gene therapy delivery in various animal models, yet there are...
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Dispersion profile of a needle-free jet injection depends on the interfacial property of the medium
Injections into or through the skin are common drug or vaccine administration routes, which can be achieved with conventional needles, microneedles,...
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Effects of Halloysite Nanotubes and Multi-walled Carbon Nanotubes on Kruppel-like Factor 15-Mediated Downstream Events in Mouse Hearts After Intravenous Injection
Halloysite nanotubes (HNTs) are nanomaterials (NMs) derived from natural clays and have been considered as biocompatible NMs for biomedical uses....
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Outer retinal transduction by AAV2-7m8 following intravitreal injection in a sheep model of CNGA3 achromatopsia
Sheep carrying a mutated CNGA3 gene exhibit diminished cone function and provide a naturally occurring large animal model of achromatopsia....
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Injection of Escherichia coli to Induce Sepsis
Mouse models of bacterial sepsis are widely used in research to investigate the underlying molecular mechanisms of sepsis and to develop clinically...
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Intramyocardial injection of human adipose-derived stem cells ameliorates cognitive deficit by regulating oxidative stress–mediated hippocampal damage after myocardial infarction
AbstractCognitive impairment is a serious side effect of post-myocardial infarction (MI) course. We have recently demonstrated that human...
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Characterization of integration frequency and insertion sites of adenovirus DNA into mouse liver genomic DNA following intravenous injection
While generally referred to as “non-integrating” vectors, adenovirus vectors have the potential to integrate into host DNA via random, illegitimate...
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In Vivo Evaluation of Almotriptan malate Formulation through Intranasal Route for the Treatment of Migraine: Systematic Development and Pharmacokinetic Assessment
Migraine headaches are usually intolerable, and a quick-relief treatment remains an unmet medical need. Almotriptan malate is a serotonin (5-HT 1B/1D )...
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Abuse, dependence and withdrawal associated with fentanyl and the role of its (designated) route of administration: an analysis of spontaneous reports from Europe
PurposeFentanyl, a highly potent synthetic opioid used in cancer and non-cancer pain, is approved for various routes of administration. In Europe,...
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Quercetin-Loaded Nanostructured Lipid Carrier In Situ Gel for Brain Targeting Through Intranasal Route: Formulation, In Vivo Pharmacokinetic and Pharmacodynamic Studies
Quercetin (QT) shows potential for protecting against neurodegenerative diseases like Alzheimer’s. However, its limited bioavailability and...
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Multiphysics Modeling and Simulation of Subcutaneous Injection and Absorption of Biotherapeutics: Model Development
PurposeMany monoclonal antibodies (mAbs) are administered via subcutaneous (SC) injection. Local transport and absorption kinetics and mechanisms,...
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Olfactory mucosa stem cells delivery via nasal route: a simple way for the treatment of Parkinson disease
Finding a simple and effective way for transferring cells to the brain lesion site with minimum side effects mounts a challenge in cell therapy. Cell...
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Subcutaneous Injection Site Pain of Formulation Matrices
PurposeThe objective of this work was to systematically evaluate the effects of formulation composition on subcutaneous injection site pain (ISP)...
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Intracerebellar injection of monocytic immature myeloid cells prevents the adverse effects caused by stereotactic surgery in a model of cerebellar neurodegeneration
BackgroundMyeloid-derived suppressor cells (MDSCs) constitute a recently discovered bone-marrow-derived cell type useful for dealing with...
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Targeted nano-delivery of chemotherapy via intranasal route suppresses in vivo glioblastoma growth and prolongs survival in the intracranial mouse model
Nanotechnology-based drug delivery platforms have shown great potential in overcoming the limitations of conventional therapy for glioblastoma (GBM)....
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Generation of Functional and Mature Sympathetic Neurons from Human Pluripotent Stem Cells via a Neuroepithelial Route
The sympathetic nervous system (SNS) is a crucial branch of the autonomic nervous system (ANS) that is responsible for regulating visceral function...
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Influence of formulation and route of administration on ketamine’s safety and tolerability: systematic review
PurposeKetamine has rapid-onset antidepressant effects in patients with treatment-resistant depression. Common side effects include dissociation (a...
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A single injection of pregabalin induces short- and long-term beneficial effects on fear memory and anxiety-like behavior in rats with experimental type-1 diabetes mellitus
Anxiety Disorders and Posttraumatic Stress Disorders (PTSD) associated with type-1 diabetes mellitus (T1DM) are increasingly common comorbidities and...
