Search
Search Results
-
Expanding Indications for a Ketogenic Diet as an Adjuvant Therapy in Adult Refractory Status Epilepticus: an Exploratory Study Using Moderation Analysis
Refractory status epilepticus (RSE) requires multimodal treatment approaches to achieve rapid seizure cessation and neuroprotection. A ketogenic diet...
-
1H magnetic resonance spectroscopy of 2H-to-1H exchange quantifies the dynamics of cellular metabolism in vivo
Quantitative map** of the in vivo dynamics of cellular metabolism via non-invasive imaging contributes to our understanding of the initiation and...
-
Magnetic Resonance Imaging in Pharmaceutical Safety Assessment
An imaging biomarker is an objective characteristic derived from an in vivo image which can indicate a normal biological process, pathogenic process,...
-
Distinct sex-specific DNA methylation differences in Alzheimer’s disease
BackgroundSex is increasingly recognized as a significant factor contributing to the biological and clinical heterogeneity in AD. There is also...
-
Longitudinal assessment of 1H-MRS (GABA and Glx) and TMS measures of cortical inhibition and facilitation in the sensorimotor cortex
The purpose of the present study was to investigate the long-term stability of water-referenced GABA and Glx neurometabolite concentrations in the...
-
MR Spectroscopy in Health and Disease
Magnetic resonance spectroscopy (MRS) enables the noninvasive quantification of up to 20 neurochemicals in selected brain regions and has found many...
-
Weissella confusa F213 ameliorated inflammation and maintained intestinal mucosa integrity in chemically induced colitis rats
ObjectiveThis study was performed to investigate the potential effects of Weissella confusa F213 (WCF213) on chemically-induced colitis rats. Twelve...
-
Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease
Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is the most common form of dominant SCA worldwide. Magnetic Resonance Imaging...
-
Imaging Biomarkers in Huntington’s Disease
Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an abnormal CAG repeat expansion in the HTT gene, that produces a mutant...
-
Imaging Techniques in Pharmacological Precision Medicine
Biomedical imaging is a powerful tool for medical diagnostics and personalized medicines. Examples of commonly used imaging modalities include...
-
The role of adenosine receptor ligands on inflammatory pain: possible modulation of TRPV1 receptor function
Chronic pain has a debilitating consequences on health and lifestyle. The currently available analgesics are often ineffective and accompanied by...
-
Altered central and blood glutathione in Alzheimer’s disease and mild cognitive impairment: a meta-analysis
BackgroundIncreasing evidence implicates oxidative stress (OS) in Alzheimer disease (AD) and mild cognitive impairment (MCI). Depletion of the brain...
-
Neurobiochemistry Alterations Associated with Major Depression: A Review of Translational Magnetic Resonance Spectroscopic Studies
Conventional magnetic resonance imaging uses water resonance to generate images of brain tissue. Here, we describe how a spectrum of potentially...
-
Reduced cortical GABA and glutamate in high schizotypy
RationaleAbnormal functioning of the inhibitory gamma-aminobutyric acid (GABA) and excitatory (glutamate) systems is proposed to play a role in the...
-
Proton magnetic resonance spectroscopy detects cerebral metabolic derangement in a mouse model of brain coenzyme a deficiency
BackgroundPantothenate kinase (PANK) is the first and rate-controlling enzymatic step in the only pathway for cellular coenzyme A (CoA) biosynthesis....
-
Histamine H2-receptor antagonism improves conduit artery endothelial function and reduces plasma aldosterone level without lowering arterial blood pressure in angiotensin II–hypertensive mice
Aldosterone through the mineralocorticoid receptor MR has detrimental effects on cardiovascular disease. It reduces the bioavailability of nitric...
-
Low-dose acetylsalicylic acid reduces local inflammation and tissue perfusion in dense breast tissue in postmenopausal women
PurposeOne major risk factor for breast cancer is high mammographic density. It has been estimated that dense breast tissue contributes to ~ 30% of...
-
In Vitro Study of Specific Properties of Probiotic Strains for Effective and Personalized Probiotic Therapy
Probiotics have tremendous potential to develop healthy diets, treatment and prevention. Investigation of in vitro cultural properties of...
-
Rapamycin Cannot Reduce Seizure Susceptibility in Infantile Rats with Malformations of Cortical Development Lacking mTORC1 Activation
The mechanistic target of the rapamycin (mTOR) pathway is involved in cortical development. However, the efficacy of mTOR inhibitors in malformations...
-
Cyclodextrin-based delivery systems for in vivo-tested anticancer therapies
Cyclodextrins (CDs) are naturally occurring macromolecules widely used as excipients on pharmaceutical formulations, evidencing a large spectrum of...
