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Silencing ApoC3 alleviates LPS-induced acute lung injury by inhibiting TLR signaling pathway
This study aims to confirm whether apolipoprotein C3 (ApoC3) can regulate the inflammatory response and tissue damage in acute lung injury (ALI) and...
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Exploiting viral sensing mediated by Toll-like receptors to design innovative vaccines
Toll-like receptors (TLRs) are transmembrane proteins belonging to the family of pattern-recognition receptors. They function as sensors of invading...
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Investigating the TLR4/TAK1/IRF7 axis in NLRP3-Mediated Pyroptosis in Parkinson's Disease
In the realm of Parkinson's disease (PD) research, NLRP3 inflammasome-mediated pyroptosis has recently garnered significant attention as a potential...
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Evaluation of the TLR negative regulatory network in CVID patients
Common variable immunodeficiency (CVID), a clinically symptomatic primary immunodeficiency disease (PID), is characterized by hypogammaglobulinemia...
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New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation
AbstractInflammasomes are important modulators of inflammation. Dysregulation of inflammasomes can enhance vulnerability to conditions such as...
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The relationship between TRAF6 and tumors
Tumor necrosis factor receptor (TNFR)-related factors (TRAFs) are important linker molecules in the tumor necrosis factor superfamily (TNFSF) and the...
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Signal-Strength and History-Dependent Innate Immune Memory Dynamics in Health and Disease
Innate immunity exhibits memory characteristics, reflected not only in selective recognition of external microbial or internal damage signals, but...
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Exosomal PPARγ derived from macrophages suppresses LPS-induced peritonitis by negative regulation of CD14/TLR4 axis
BackgroundIntercellular communication between macrophages and peritoneal mesothelial cells (PMCs) has been suggested as a key factor regulating...
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Docosahexaenoic fatty acid reduces the pro‐inflammatory response induced by IL-1β in astrocytes through inhibition of NF-κB and AP-1 transcription factor activation
BackgroundAstrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the...
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The Neuroimmune System and the Cerebellum
The recognition that there is an innate immune system of the brain, referred to as the neuroimmune system, that preforms many functions comparable to...
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Exploring the immune interactions between Oncomelania hupensis and Schistosoma japonicum, with a cross-comparison of immunological research progress in other intermediate host snails
Schistosomiasis, the second largest parasitic disease in the world after malaria, poses a significant threat to human health and causes public health...
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Role of Toll-Like Receptors in Molecular and Cellular Mechanisms of Respiratory Diseases
The family of toll-like receptors (TLRs) is receiving considerable attention as potential regulators and controllers of the immune response through...
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Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells
Dendritic cells (DCs) are professional antigen presenting cells that play a critical role in bridging innate and adaptive immunity. Numerous studies...
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Detection of Deregulated miRNAs in Childhood Epileptic Encephalopathies
The term “epileptic encephalopathy” is used to describe a possible relationship between epilepsy and developmental delay. The pathogenesis of...
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The genetic basis of pneumococcal and staphylococcal infections: inborn errors of human TLR and IL-1R immunity
Many bacteria can cause pyogenic lesions in humans. Most of these bacteria are harmless in most individuals, but they, nevertheless, cause...
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The wheat stem rust resistance gene Sr43 encodes an unusual protein kinase
To safeguard bread wheat against pests and diseases, breeders have introduced over 200 resistance genes into its genome, thus nearly doubling the...
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Macrophage Targeting for Therapy of Cardiovascular Diseases (CVD)
Cardiac macrophages can be classified into primitive resident macrophages and blood-borne infiltrating macrophages. Primitive resident macrophages...
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Endotoxin tolerance and low activation of TLR-4/NF-κB axis in monocytes of COVID-19 patients
AbstractHigher endotoxin in the circulation may indicate a compromised state of host immune response against coinfections in severe COVID-19...
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Processing stimulus dynamics by the NF-κB network in single cells
Cells at the site of an infection experience numerous biochemical signals that vary in amplitude, space, and time. Despite the diversity of dynamic...
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Medicinal uses, phytochemistry, pharmacology, and taxonomy of Poygonum aviculare L.: a comprehensive review
Polygonum aviculare is a plant widely distributed in all continents and very common in temperate regions of the world. The different parts of this...
