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PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine
Anti-programmed death-1 (anti-PD-1) immunotherapy reinvigorates CD8 T cell responses in patients with cancer but PD-1 is also expressed by other...
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Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly...
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Enhancing breadth and durability of humoral immune responses in non-human primates with an adjuvanted group 1 influenza hemagglutinin stem antigen
Seasonal influenza vaccines must be updated annually and suboptimally protect against strains mismatched to the selected vaccine strains. We...
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Natural Human Immune Response Identifies An Unnatural Oncology Target for Immunotherapy
The intelligence of the natural human immune response can be exploited to recognize antigenic targets useful in oncology. A component of this...
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Predicting humoral responses to primary and booster SARS-CoV-2 mRNA vaccination in people living with HIV: a machine learning approach
BackgroundSARS-CoV-2 mRNA vaccines are highly immunogenic in people living with HIV (PLWH) on effective antiretroviral therapy (ART). However,...
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Vertebrate Immune Systems
All cellular organisms have some form of immunity from microbial pathogens. The two main forms of immunity are innate and acquired immunity. Innate...
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Humoral immunity to SARS-CoV-2 in kidney transplant recipients and dialysis patients: IgA and IgG patterns unraveled after SARS-CoV-2 infection and vaccination
BackgroundInfection with SARS-CoV-2 in high-risk groups such as kidney transplant and dialysis patients is shown to be associated with a more serious...
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Humoral immune response to tumor-associated antigen Ubiquilin 1 (UBQLN1) and its tumor-promoting potential in lung cancer
BackgroundThis study aims to investigate the expression of UBQLN1 in lung cancer (LC) tissue and the diagnostic capability of autoantibody to UBQLN1...
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Safety and immune response kinetics of GRAd-COV2 vaccine: phase 1 clinical trial results
Despite the successful deployment of efficacious vaccines and therapeutics, the development of novel vaccines for SARS-CoV-2 remains a major goal to...
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Redox regulation of the immune response
The immune-inflammatory response is associated with increased nitro-oxidative stress. The aim of this mechanistic review is to examine: (a) the role...
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MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination
Global pandemics caused by influenza or coronaviruses cause severe disruptions to public health and lead to high morbidity and mortality. There...
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A longitudinal study of humoral immune responses induced by a 3-dose inactivated COVID-19 vaccine in an observational, prospective cohort
BackgroundTo determine the dynamic SARS-CoV-2 specific antibody levels induced by 3 doses of an inactivated COVID-19 vaccine, CoronaVac. An...
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Assessment of the Gene Therapy Immune Response in the Canine Muscular Dystrophy Model
The immune response is a primary hurdle in the development of gene therapy for neuromuscular diseases. Both innate and adaptive immune responses have...
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The dengue-specific immune response and antibody identification with machine learning
Dengue virus poses a serious threat to global health and there is no specific therapeutic for it. Broadly neutralizing antibodies recognizing all...
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Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection
Ineffective antibody-mediated responses are a key characteristic of chronic viral infection. However, our understanding of the intrinsic mechanisms...
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A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs
BackgroundInfluenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes...
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Humoral immunity for durable control of SARS-CoV-2 and its variants
The coronavirus disease 2019 (COVID-19) pandemic is ongoing because of the repeated emergence of severe acute respiratory syndrome coronavirus 2...
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Th1-dominant cytokine responses in kidney patients after COVID-19 vaccination are associated with poor humoral responses
Cytokines are regulators of the immune response against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, the contribution of...
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Immune response induced by standard and fractional doses of 17DD yellow fever vaccine
The re-emergence of yellow fever (YF) urged new mass vaccination campaigns and, in 2017, the World Health Organization approved the use of the...
