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Identifying novel transcript biomarkers for hepatocellular carcinoma (HCC) using RNA-Seq datasets and machine learning
BackgroundHepatocellular carcinoma (HCC) is one of the leading causes of cancer death in the world owing to limitations in its prognosis. The current...
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Genotype-Dependent Gene Expression in Strawberry (Fragaria x ananassa) Plants Under High Temperature Stress
The differences in tolerance to high temperatures were investigated on the basis of gene expressions in two strawberry ( Fragaria x ananassa Duch)...
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The Use of 3D In Vitro Systems to Model Human Malaria
This chapter contains a discussion on the potential use of liver organoid to understand biological complexity of cellular and molecular mechanisms...
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Crosstalk between endoplasmic reticulum and cytosolic unfolded protein response in tomato
Conditions that cause proteotoxicity like high temperature trigger the activation of unfolded protein response (UPR). The cytosolic (CPR) and...
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Evolution of chaperome gene expression and regulatory elements in the antarctic notothenioid fishes
Confined within the cold-stable Southern Ocean, Antarctic notothenioid fishes have undergone an evolutionary loss of the inducible heat shock...
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The Role of HSP90 Molecular Chaperones in Depression: Potential Mechanisms
Major depressive disorder (MDD) is characterized by high rates of disability and death and has become a public health problem that threatens human...
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Heat shock protein A4 ablation leads to skeletal muscle myopathy associated with dysregulated autophagy and induced apoptosis
BackgroundMolecular chaperones assist protein folding, facilitate degradation of misfolded polypeptides, and thereby maintain protein homeostasis....
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Short-term cold stress and heat shock proteins in the crustacean Artemia franciscana
In their role as molecular chaperones, heat shock proteins (Hsps) mediate protein folding thereby mitigating cellular damage caused by physiological...
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The Evolution of Concepts about the Biological Role of Lampbrush Chromosomes
AbstractThe review is focused on the development of ideas about the role of one of the most mysterious phenomena of developmental biology, i.e., the...
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Heat Shock Factors in Protein Quality Control and Spermatogenesis
Proper regulation of cellular protein quality control is crucial for cellular health. It appears that the protein quality control machinery is...
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Transcriptional Regulation in Sugarcane under Water Deficit during Formative Growth Stage
AbstractPresent study was intended to examine the comparative transcript profile of six drought-responsive genes under water deficit conditions in...
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Exosomes in the pathogenesis and treatment of cancer-related cachexia
Cancer-related cachexia is a metabolic syndrome characterized by weight loss, adipose tissue decomposition, and progressive skeletal muscle atrophy....
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Genome-wide expression analysis reveals different heat shock responses in indigenous (Bos indicus) and crossbred (Bos indicus X Bos taurus) cattle
Environmental heat stress in dairy cattle leads to poor health, reduced milk production and decreased reproductive efficiency. Multiple genes...
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Transcriptome Analysis of Persian Oak (Quercus brantii L.) Decline Using RNA-seq Technology
Since the late 1980s, the oak decline has affected the Zagros oak forests in western Iran. Persian oak ( Quercus brantii L.) the most important tree...
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Alternative splicing in multiple myeloma is associated with the non-homologous end joining pathway
Alternative splicing plays a pivotal role in tumorigenesis and proliferation. However, its pattern and pathogenic role has not been systematically...
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A single-cell transcriptome atlas of human euploid and aneuploid blastocysts
Aneuploidy is frequently detected in early human embryos as a major cause of early pregnancy failure. However, how aneuploidy affects cellular...
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Technologies Used for Analysis of Extracellular Vesicle-Omics
Extracellular vesicles (EVs) are naturally occurring and secreted membrane vesicles that carry proteins, lipids, and RNAs (mRNAs, microRNAs [miRNAs],...
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Astrocyte-Derived Exosomes in an iPSC Model of Bipolar Disorder
Bipolar I Disorder (BP) is a serious, recurrent mood disorder that is characterized by alternating episodes of mania and depression. To begin to...
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Quantum Medicine and the Immune System
Currently, physics plays a central role in medicine, imaging diagnostics, and in oncology, radiotherapy and hadron therapy, photodynamic therapy or...
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Cancer-Associated Fibroblasts Boost Tumorigenesis of Clear Cell Renal Cell Carcinoma via Exosome-Mediated Paracrine SNHG1
Despite the dominant roles of cancer-associated fibroblasts (CAFs) have attached much attention in tumorigenesis, the CAFs-derived molecular...
