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1. Therapeutic Application of Microbial Metabolites in Free Radical–Induced Tumorigenesis

   Reactive oxygen species (ROS) such as superoxide, hydroxyl radical, and hydrogen peroxide are responsible for the development of tumors by causing...

   Indranil Chattopadhyay in Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

   Reference work entry 2022
   

2. Therapeutic Application of Microbial Metabolites in Free Radical Induced Tumorigenesis

   Reactive oxygen species (ROS) such as superoxide, hydroxyl radical, and hydrogen peroxide are responsible for the development of tumors by causing...

   Indranil Chattopadhyay in Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

   Living reference work entry 2022
   

3. Circulatory metabolites trigger ex vivo arterial endothelial cell dysfunction in population chronically exposed to diesel exhaust

   Background

   Chronic exposure to diesel exhaust has a causal link to cardiovascular diseases in various environmental and occupational settings....

   Wenting Cheng, Huanhuan Pang, ... **glong Tang in Particle and Fibre Toxicology

   Article Open access 22 March 2022
   

4. Bioactive Metabolites from Fungi with Anti-Inflammatory and Antithrombotic Properties: Current Status and Future Perspectives for Drug Development

   Bioactives of natural origin have recently gained a lot of ground in drug discovery due to their enormous structural diversity, diverse...

   Alexandros Tsoupras, Kyeesha Glenn Davi in Fungi Bioactive Metabolites

   Chapter 2024
   

5. Ecstasy metabolites and monoamine neurotransmitters upshift the Na⁺/K⁺ ATPase activity in mouse brain synaptosomes

   3,4-Methylenedioximethamphetamine (MDMA; “ecstasy”) is a psychotropic drug with well-known neurotoxic effects mediated by hitherto not fully...

   Daniel José Barbosa, João Paulo Capela, ... Félix Carvalho in Archives of Toxicology

   Article 14 September 2022
   

6. Endogenous cortisol excess confers a unique lipid signature and metabolic network

   Abstract

   Chronic cortisol excess induces several alterations on protein, lipid and carbohydrate metabolism resembling those found in the metabolic...

   Arturo Vega-Beyhart, Marta Iruarrizaga, ... Felicia A Hanzu in Journal of Molecular Medicine

   Article 21 April 2021
   

7. Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease

   Background

   Braak’s hypothesis states that sporadic Parkinson’s disease (PD) follows a specific progression of pathology from the peripheral to the...

   Yogesh Singh, Christoph Trautwein, ... Nicolas Casadei in Molecular Neurodegeneration

   Article Open access 04 July 2023
   

8. Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation

   Background

   Sleep loss is a serious global health concern. Consequences include memory deficits and gastrointestinal dysfunction. Our previous research...

   **ntong Wang, Zixu Wang, ... Yaoxing Chen in Microbiome

   Article Open access 31 January 2023
   

9. Endophytic Mycoflora: Antibacterial Secondary Metabolites and Their Therapeutic Potential

   Purpose of Review

   Nowadays, the need of novel biological active compounds is growing as there is remarkable increase in antibiotic resistance...

   Ravindra Prasad Aharwal, Suneel Kumar, Sardul Singh Sandhu in Current Pharmacology Reports

   Article 10 August 2021
   

10. Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs

    Medulloblastoma (MB) is the most common malignant brain tumor in children. There remains an unmet need for diagnostics to sensitively detect the...

    Bongyong Lee, Iqbal Mahmud, ... Ranjan J. Perera in Acta Neuropathologica Communications

    Article Open access 24 February 2022
    

11. P-glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Main Active Heroin Metabolites 6-monoacetylmorphine (6-MAM) and Morphine in Mice

    Background & Purpose

    Heroin (diacetylmorphine; diamorphine) is a highly addictive opioid prodrug. Heroin prescription is possible in some countries...

    Margarida L. F. Martins, Nancy H. C. Loos, ... Alfred H. Schinkel in Pharmaceutical Research

    Article 21 June 2023
    

12. Increased exogenous but unaltered endogenous carbohydrate oxidation with combined fructose-maltodextrin ingested at 120 g h⁻¹ versus 90 g h⁻¹ at different ratios

    Purpose

    This study aimed to investigate whether carbohydrate ingestion during 3 h long endurance exercise in highly trained cyclists at a rate of...

    Tim Podlogar, Špela Bokal, ... Gareth A. Wallis in European Journal of Applied Physiology

    Article Open access 11 August 2022
    

13. Milk oligosaccharide-driven persistence of Bifidobacterium pseudocatenulatum modulates local and systemic microbial metabolites upon synbiotic treatment in conventionally colonized mice

    Background

    Bifidobacteria represent an important gut commensal in humans, particularly during initial microbiome assembly in the first year of life....

    Jules A. Larke, Britta E. Heiss, ... Carolyn M. Slupsky in Microbiome

    Article Open access 28 August 2023
    

14. The convergent application of metabolites from Avena sativa and gut microbiota to ameliorate non-alcoholic fatty liver disease: a network pharmacology study

    Background

    Non-alcoholic fatty liver disease (NAFLD) is a serious public health issue globally, currently, the treatment of NAFLD lies still in the...

    Ki-Kwang Oh, Sang-Jun Yoon, ... Ki-Tae Suk in Journal of Translational Medicine

    Article Open access 17 April 2023
    

15. Plant Secondary Metabolites: An Introduction of Their Chemistry and Biological Significance with Physicochemical Aspect

    Nature is the immense source of chemical compounds or substances usually acknowledged as natural products. Plants are the considerable source of an...

    Ajay Sharma, Saurabh Sharma, ... Anil Kumar Sharma in Plant Secondary Metabolites

    Chapter 2022
    

16. Endogenous Kynurenic Acid and Neurotoxicity

    Tryptophan metabolism along with kynurenine pathway yields a number of neuroactive compounds. Among kynurenine derivatives, neuroprotective kynurenic...

    Ewa M. Urbańska, Iwona Chmiel-Perzyńska, ... Björn Owe-Larsson in Handbook of Neurotoxicity

    Living reference work entry 2021
    

17. Combined in vivo metabolic effects of quetiapine and methadone in brain and blood of rats

    Changes in pharmacokinetics and endogenous metabolites may underlie additive biological effects of concomitant use of antipsychotics and opioids. In...

    Laura Smedegaard Heisel, Freja Drost Andersen, ... Kirstine Lykke Nielsen in Archives of Toxicology

    Article Open access 23 October 2023
    

18. Estrogenic in vitro evaluation of zearalenone and its phase I and II metabolites in combination with soy isoflavones

    Humans and animals are exposed to multiple substances in their food and feed that might have a negative health impact. Among these substances, the Fusarium...

    Dino Grgic, Andrea Betschler, ... Doris Marko in Archives of Toxicology

    Article Open access 20 August 2022
    

19. Role of Plant Secondary Metabolites in Metabolic Disorders

    Living cells are actively engaged in conducting various processes, sustaining the survival of cells, depending on highly orchestrated biochemical...

    Younis Ahmad Hajam, Raksha Rani, ... Rajesh Kumar in Plant Secondary Metabolites

    Chapter 2022
    

20. A simple preparation step to remove excess liquid lipids in white adipose tissue enabling improved detection of metabolites via MALDI-FTICR imaging MS

    Matrix-assisted laser desorption ionization (MALDI) Fourier transform ion cyclotron resonance (FTICR) imaging mass spectrometry (MS) is a powerful...

    Qian Wang, Na Sun, ... Axel Walch in Histochemistry and Cell Biology

    Article Open access 07 April 2022