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Deconvoluting the relationships between autophagy and metastasis for potential cancer therapy
Autophagy is a highly conserved lysosome-dependent degradation process that may digest some long-lived proteins and damaged organelles. As an...
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Tyrosyl Phosphorylated Serine-Threonine Kinase PAK1 is a Novel Regulator of Prolactin-Dependent Breast Cancer Cell Motility and Invasion
Despite efforts to discover the cellular pathways regulating breast cancer metastasis, little is known as to how prolactin (PRL) cooperates with...
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Thiamin supplementation does not reduce the frequency of adverse events after anti-malarial therapy among patients with falciparum malaria in southern Laos
BackgroundIn a recent study one third of Lao patients presenting with uncomplicated Plasmodium falciparum malaria had biochemical evidence of...
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Role of T-Type Calcium Channels in Neuroendocrine Differentiation
Neuroendocrine cells release their secretory products into the extracellular environment via a calcium-dependent pathway. These particular cells...
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Interleukin-2-Inducible T-Cell Kinase (ITK) Deficiency - Clinical and Molecular Aspects
In patients with underlying immunodeficiency, Epstein-Barr virus (EBV) may lead to severe immune dysregulation manifesting as fatal mononucleosis,...
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Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer
BackgroundThymoquinone (TQ) was shown to reduce tumor growth in several cancer models both in vitro and in vivo . So far only a few targets of TQ,...
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TNF-α signalling and inflammation: interactions between old acquaintances
IntroductionInflammation is a very important part of innate immunity and is regulated in many steps. One such regulating step is the cytokine...
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Tyrosine Kinases in Prostate Cancer
Tyrosine kinases play essential roles in regulating cell proliferation and differentiation. Deregulation of the key tyrosine kinases governing these...
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Regulation of the Jak/STATs Pathways by Histone Deacetylases
The regulation of the Jak/STAT pathways involves multiple mechanisms, some of them exclusive to individual cascades, and other shared amongst them....
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The Role of Inflammation in Kidney Cancer
Renal cell carcinoma (RCC) constitutes more than 90 % of primary kidney tumors with the development of metastatic disease in the lung, bone, liver,...
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Androgen-Independent Induction of Androgen-Responsive Genes by Interleukin-6 Regulation
Androgen receptor (AR) is expressed in recurrent prostate cancer and its increased activation could be a consequence of protein stabilization, point...
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Towards Targeted Therapy of Chronic Lymphocytic Leukemia
The B cell antigen receptor (BCR) and its downstream pathways are pivotal in the pathogenesis of chronic lymphocytic leukemia (CLL). Recently,...