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The detectable anti-interferon-γ autoantibodies in COVID-19 patients may be associated with disease severity
BackgroundNeutralizing anti-interferon (IFN)-γ autoantibodies are linked to adult-onset immunodeficiency and opportunistic infections.
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Severity of Obstructive Sleep Apnea and Associated Comorbidities
PurposeObstructive sleep apnea (OSA) associated comorbidities including hypertension, cardiovascular disease, diabetes mellitus has been reported in...
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Host genetic factors of COVID-19 susceptibility and disease severity in a Thai population
Host genetic factors have been shown to play a role in SARs-CoV-2 infection in diverse populations. However, the genetic landscape differs among...
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A summary index derived from Kinect to evaluate postural abnormalities severity in Parkinson’s Disease patients
Postural abnormalities are common disabling motor complications affecting patients with Parkinson’s disease (PD). We proposed a summary index for...
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Older adults at greater risk for Alzheimer’s disease show stronger associations between sleep apnea severity in REM sleep and verbal memory
BackgroundObstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer’s disease (AD). While the underlying mechanisms remain...
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Longitudinal corpus callosum microstructural decline in early-stage Parkinson’s disease in association with akinetic-rigid symptom severity
Previous diffusion tensor imaging (DTI) studies of Parkinson’s disease (PD) show reduced microstructural integrity of the corpus callosum (CC)...
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Gait classification for early detection and severity rating of Parkinson’s disease based on hybrid signal processing and machine learning methods
Parkinson’s disease (PD) is one of the cognitive degenerative disorders of the central nervous system that affects the motor system. Gait dysfunction...
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Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammation
BackgroundLRRK2-targeting therapeutics that inhibit LRRK2 kinase activity have advanced to clinical trials in idiopathic Parkinson’s disease (iPD)....
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Early and strong antibody responses to SARS-CoV-2 predict disease severity in COVID-19 patients
BackgroundAntibody response to SARS-CoV-2 is a valuable biomarker for the assessment of the spread of the virus in a population and evaluation of the...
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Comparative Study of the Levels of IL-1β, IL-4, IL-8, TNFα, and IFNγ in Stable Course and Exacerbation of Chronic Obstructive Pulmonary Disease of Varying Severity
In patients with chronic obstructive pulmonary disease, the levels of cytokines IL-1β, IL-4, IL-8, TNFα, and IFNγ depended on the degree of bronchial...
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The mitochondrial protein TSPO in Alzheimer’s disease: relation to the severity of AD pathology and the neuroinflammatory environment
The 18kD translocator protein (TSPO) is used as a positron emission tomography (PET) target to quantify neuroinflammation in patients. In Alzheimer’s...
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Negotiating severity behind the scenes: prenatal testing in Germany
Foetal-related severity is a key concept in policy and legislation relating to access to both reproductive technologies and selective abortions in...
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Neutralizing the free radicals could alleviate the disease severity following an infection by positive strand RNA viruses
Free radical release due to oxidative stress is gaining importance in the field of viral pathogenesis. Recent studies suggest the involvement of...
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Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels
BackgroundAdvances in ultrasensitive detection of phosphorylated tau (p-tau) in plasma has enabled the use of blood tests to measure Alzheimer’s...
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Elevated Levels of Soluble CD147 are Associated with Hyperinflammation and Disease Severity in COVID-19: A Proof-of-Concept Clinical Study
To evaluate soluble CD147 levels in COVID-19 and identify whether these are associated with hyperinflammation and disease severity. One-hundred and...
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Cerebellar Volumetry in Ataxias: Relation to Ataxia Severity and Duration
Cerebellar atrophy is the neuropathological hallmark of most ataxias. Hence, quantifying the volume of the cerebellar grey and white matter is of...
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Neutrophil Extracellular Trap Formation Potential Correlates with Lung Disease Severity in COVID-19 Patients
Severe lung inflammation is common in life-threatening coronavirus disease 2019 (COVID-19). This study tested the hypothesis that polymorphonuclear...
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Early-Life Social Determinants of SCA6 Age at Onset, Severity, and Progression
SCA6 patients with the same size CAG repeat allele can vary significantly in age at onset (AAO) and clinical progression. The specific external...
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Sex differences in Alzheimer’s disease: plasma MMP-9 and markers of disease severity
BackgroundStudies have reported higher plasma matrix metalloproteinase-9 (MMP-9) levels in mild cognitive impairment (MCI) and Alzheimer’s disease...
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Beyond severity: utility as a criterion for setting the scope of RGCS
Reproductive genetic carrier screening (RGCS) allows prospective parents to identify and act upon their chances of having a child with a genetic...