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In Vivo and In Vitro Immunohistochemical Visualization of Neural Cell Apoptosis and Autophagy
In this chapter, we discuss several immunohistochemicalimmunohistochemical methods to monitor apoptosisapoptosis...
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Ryanodine Receptor 1 and Associated Pathologies
In skeletal muscle a rise in the cytosolic calcium concentration is the first trigger able to initiate the contraction of the sarcomere....
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Tumor Development
This subchapter deals with the properties of tumors that occur in humans and experimental animals. The chapter starts with the definition of tumors,...
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Long-distance retrograde neurotrophic factor signalling in neurons
The specialized architecture of neurons necessitates unique modes of intracellular communication to allow for cell survival, the ability to detect...
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Paradoxical contribution of SK3 and GIRK channels to the activation of mouse vomeronasal organ
The vomeronasal organ (VNO) is essential for intraspecies communication in many terrestrial vertebrates. The ionic mechanisms of VNO activation...
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Mitochondrial Disorders
Mitochondria, double-membrane organelles, are the major site of energy production and vital components of all eukaryotic cells because of the...
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A Young Adult with Sarcosinemia. No Benefit from Long Duration Treatment with Memantine
Sarcosinemia is a rare inborn error of metabolism that is characterised by an increased level of sarcosine (N-methylglycine) in the plasma and urine....
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Synaptic Wnt signaling—a contributor to major psychiatric disorders?
Wnt signaling is a key pathway that helps organize development of the nervous system. It influences cell proliferation, cell fate, and cell migration...
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Regulation of Cytoskeletal Composition in Neurons: Transcriptional and Post-transcriptional Control in Development, Regeneration, and Disease
The neuronal cytoskeleton consists of microfilaments, microtubules, and neurofilaments, which are composed of actins, tubulins, and neurofilament...
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microRNAs and genetic diseases
microRNAs (miRNAs) are a class of small RNAs (19-25 nucleotides in length) processed from double-stranded hairpin precursors. They negatively...
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Origin of renal myofibroblasts in the model of unilateral ureter obstruction in the rat
Tubulo-interstitial fibrosis is a constant feature of chronic renal failure and it is suspected to contribute importantly to the deterioration of...
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Changes in open-field activity and novelty-seeking behavior in periadolescent rats neonatally treated with monosodium glutamate
Monosodium glutamate (MSG) treatment of neonatal rodents leads to degeneration of the neurons in the arcuate nucleus, inner retinal layers and...