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Echinococcosis
Cystic echinococcosis (CE) and alveolar echinococcosis (AE) are zoonoses of great medical and veterinary importance, caused by Echinococcus...
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Embryonal Tumors of the Central Nervous System with Multilayered Rosettes and Atypical Teratoid/Rhabdoid Tumors
The 2016 WHOWorld Health Organization (WHO) classification of tumors of the central nervous systemCentral nervous system (CNS) affected importantly...
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Advanced Drug Delivery Systems Targeting the Immune System at Cellular Level in Chronic Respiratory Diseases
Cellular components of the human immune system, especially the neutrophils and macrophages play a massive role in the pathogenesis of a variety of...
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Obstructive Airway Diseases
Asthma, COPD (including chronic bronchitis and emphysema), and bronchiectasis are the commonly encountered obstructive airway diseases. Symptomatic...
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Brain and Spinal Tumors Originating from the Germ Line Cells
Primary central nervous systemCentral nervous system (CNS) germ cell tumorsGerm cell tumors (GCT) (CNS GCTs) are part of the GCTs in children and...
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Imprinted gene detection effectively improves the diagnostic accuracy for papillary thyroid carcinoma
BackgroundPapillary thyroid carcinoma (PTC) is the most frequent histological type of thyroid carcinoma. Although an increasing number of diagnostic...
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Malignant Brain and Spinal Tumors Originating from Bone or Cartilage
MalignantMalignant boneBone tumors affecting the brain and spineSpine are a rare and exceedingly difficult-to-treat group of diseases. Most commonly...
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Benign and Malignant Tumors of the Pituitary Gland
Pituitary glandPituitary gland tumors represent approximately 10–15% of all brain tumorsBrain tumor and the most common neoplasmsNeoplasm of the...
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Biomarkers in Renal Cell Carcinoma
Renal cell carcinoma (RCC) constitutes 90% of all kidney tumours. It also accounts for higher mortality rates of up to 30–40% as compared to prostate...
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Brain and/or Spinal Cord Tumors Accompanied with Other Diseases or Syndromes
Several medical conditions that interest both the brain and the spinal cordSpinal cord have been described throughout the history of medicine....
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Par-4 in Apoptosis during Human Salivary Gland Development and Tumorigenesis
Human salivary glands (SGs) are complex structures comprising a system of ducts and acini formed in gradual stages termed the prebud, initial bud,...
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From basic research to clinical application: targeting fibroblast activation protein for cancer diagnosis and treatment
PurposeThis study aims to review the multifaceted roles of a membrane protein named Fibroblast Activation Protein (FAP) expressed in tumor tissue,...
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Characteristics of familial pancreatic cancer families with additional colorectal carcinoma
Familial pancreatic cancer (FPC) is a rare hereditary tumor entity with broad phenotypic heterogeneity, including colorectal carcinoma (CRC) in some...
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Modeling the enigma of complex disease etiology
BackgroundComplex diseases often present as a diagnosis riddle, further complicated by the combination of multiple phenotypes and diseases as...
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Diagnosis of Neoplastic and Paraneoplastic Cerebellar Ataxia
Acquired cerebellar ataxia encompasses various diseases. Neoplastic causes have specific characteristics. First, because of the limited space in the...
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Novel ATXN1/ATXN1L::NUTM2A fusions identified in aggressive infant sarcomas with gene expression and methylation patterns similar to CIC-rearranged sarcoma
CIC -rearranged sarcomas are newly defined undifferentiated soft tissue tumors with CIC- associated fusions, and dismal prognosis. CIC fusions activate...
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Decoding the basis of histological variation in human cancer
Molecular abnormalities that shape human neoplasms dissociate their phenotypic landscape from that of the healthy counterpart. Through the lens of a...
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A novel autoantibody signatures for enhanced clinical diagnosis of pancreatic ductal adenocarcinoma
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a devastating disease that requires precise diagnosis for effective treatment. However, the...
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Brain Tumors Affecting the Orbit Globe and Orbit Tumors Affecting the Brain
Brain tumorsBrain tumor affecting the orbitOrbit and orbital tumorsOrbital tumors affecting the brain are a heterogeneousHeterogeneous group of...