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PITX2 enhances progression of lung adenocarcinoma by transcriptionally regulating WNT3A and activating Wnt/β-catenin signaling pathway
BackgroundThe homeodomain transcription factor, PITX2 is associated with tumorigenesis of multiple cancers. In this research, we aimed to study the...
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Chromosome 4q25 Variants rs2200733, rs10033464, and rs1906591 Contribute to Ischemic Stroke Risk
Previous studies have shown an association between chromosome 4q25 variants (rs2200733, rs10033464, and rs1906591) and the risk of ischemic stroke....
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Association of common genetic variants related to atrial fibrillation and the risk of ventricular fibrillation in the setting of first ST-elevation myocardial infarction
BackgroundCohort studies have revealed an increased risk for ventricular fibrillation (VF) and sudden cardiac death (SCD) in patients with atrial...
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Progress of Genomics in Cardiac Conduction and Rhythm Disorders
Genes and genetic loci linked thus far to cardiac electrical function and arrhythmia have been primarily uncovered through numerous studies. The...
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Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia in clinical routine. AF is related to significant morbidity and mortality caused by...
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Genetics of congenital hypogonadotropic hypogonadism: peculiarities and phenotype of an oligogenic disease
A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be defined in almost 50% of cases, albeit not necessarily the complete...
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The role of osteopontin in kidney diseases
BackgroundOsteopontin (OPN) is a pleiotropic glycoprotein expressed in various cell types in animals and in humans, including bone, immune, smooth...
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CDKN2B downregulation and other genetic characteristics in T-acute lymphoblastic leukemia
We identified principal genetic alterations in 97.1% (99/102) of patients with T-acute lymphoblastic leukemia (T-ALL) using integrative genetic...
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MicroRNA-655-3p and microRNA-497-5p inhibit cell proliferation in cultured human lip cells through the regulation of genes related to human cleft lip
BackgroundThe etiology of cleft lip with or without cleft palate (CL/P), a common congenital birth defect, is complex and involves the contribution...
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Monogenic, Polygenic, and MicroRNA Markers for Ischemic Stroke
Ischemic stroke (IS) is a leading disease with high mortality and disability, as well as with limited therapeutic window. Biomarkers for earlier...
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Molecular pathogenesis of interstitial cystitis based on microRNA expression signature: miR-320 family-regulated molecular pathways and targets
Interstitial cystitis (IC), also known as bladder pain syndrome, is a chronic inflammatory disease that affects the bladder. The symptoms of IC vary,...
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Multipoint genome-wide linkage scan for nonword repetition in a multigenerational family further supports chromosome 13q as a locus for verbal trait disorders
Verbal trait disorders encompass a wide range of conditions and are marked by deficits in five domains that impair a person’s ability to communicate:...
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Multi-ethnic genome-wide association study for atrial fibrillation
Atrial fibrillation (AF) affects more than 33 million individuals worldwide
1 and has a complex heritability2 . We conducted the largest meta-analysis...
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Genetics of Adult and Fetal Forms of Long QT Syndrome
Long QT syndrome (LQTS) is an inherited cardiac disease characterized by prolongation of QT interval at surface ECG, T-wave abnormalities, and high...
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Risks associated with the stroke predisposition at young age: facts and hypotheses in light of individualized predictive and preventive approach
Stroke is one of the most devastating pathologies of the early twenty-first century demonstrating 1-month case-fatality rates ranging from 13 to 35%...
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Genetic Testing for Inheritable Cardiac Channelopathies
Inheritable cardiac channelopathies (ICC) are defined as primary electrical disorders without identifiable cardiac structural abnormalities and are...