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In vitro activity of aztreonam–avibactam against Enterobacterales isolates collected in Latin America, Africa/Middle East, Asia, and Eurasia for the ATLAS Global Surveillance Program in 2019–2021
This study aimed to report reference method antimicrobial susceptibility results for 24,937 recent (2019–2021) clinical isolates of Enterobacterales...
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External ventriculostomy-associated infection reduction after updating a care bundle
BackgroundDespite the clinical benefits of external ventricular drains (EVD), these devices can lead to EVD-related infections (EVDRI). The drainage...
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Epidemiology of community origin of major multidrug-resistant ESKAPE uropathogens in a paediatric population in South-East Gabon
BackgroundUrinary tract infections (UTIs) in children are very common. They are often associated with a high risk of sepsis and death. In recent...
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High prevalence of MDR gram-negative bacteria in feces of healthy blood donors in Mexico
During the initial stage of a study to recruit universal intestinal microbiota donors in Mexico City, we found multiple “healthy” subjects that...
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The role of hospital environment in transmissions of multidrug-resistant gram-negative organisms
Infections by multidrug-resistant (MDR) Gram-negative organisms (GN) are associated with a high mortality rate and present an increasing challenge to...
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Comparison of colistin-induced nephrotoxicity between two different formulations of colistin in critically ill patients: a retrospective cohort study
BackgroundColistin is widely used in the treatment of nosocomial infections caused by carbapenem-resistant gram-negative bacilli (CR-GNB)....
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New Tetracyclines: Eravacycline and Omadacycline
The development of tetracyclines began in the 1940s with discovery of the natural product, chlortetracycline. Widespread use over the years led to...
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Antimicrobial Resistance: An Overview
Recounting the struggle against infectious diseases reconciles us with the failures. Following discovery, clinical implementation of different...
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Newer Antibiotic Agents in Pipeline
Multi-drug resistance (MDR) and extensive-drug resistance (XDR) have become common, making care of many patients difficult. The rise in resistance...
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Clinical Approach to Treatment of Bacterial Infections
The determination that a patient has a bacterial infection can be made on the basis of the history, physical examination, and clinical setting, or it...
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Gastrointestinal colonization by OXA-48-producing Enterobacterales: risk factors for persistent carriage
Carbapenem-resistant Enterobacterales (CRE) infections are a major health problem. Intestinal colonization is a key factor in develo** infection....
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Medical Importance of ESKAPE Pathogens
Being the ‘escapers’ from the action of antibiotics, the ESKAPE pathogens—Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae,...
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Antimicrobial Resistance: A Crisis in the Making
Antimicrobial resistance (AMR) is considered the silent pandemic that threatens the global public health systems and one of the biggest threats to...
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Short- versus long-course therapy in gram-negative bacilli bloodstream infections
Bacteremia due to gram-negative bacilli (GNB) is one of the most frequent causes of admission and prolongation of hospital stay. Nevertheless,...
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Ceftazidime–avibactam treatment in bacteremia caused by OXA-48 carbapenemase-producing Klebsiella pneumoniae
Therapeutic options for bacteremia caused by carbapenem-resistant Enterobacterales (CRE) OXA-48-type are limited. The objective of this study was to...
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Phenotypic and genotypic identification of carbapenem resistance in Bacteroides fragilis clinical strains
Bacteroides fragilis is an important etiological agent of serious infections in humans. Rapid methods, readily adaptable to use in medical...
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Antimicrobial Therapy
Any chemical used in treatment, relief or prophylaxis of disease is defined as a chemotherapeutic drug or agent. When chemotherapeutic drugs are...
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Extensive outbreak of colistin resistant, carbapenemase (blaOXA-48, blaNDM) producing Klebsiella pneumoniae in a large tertiary care hospital, India
BackgroundExtensive drug resistance in Klebsiella pneumoniae ( K. pneumoniae ) causing major outbreaks in large hospitals is an emerging challenge. We...
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Nucleic Acid Amplification and Molecular Diagnostic Techniques in the Detection of ESKAPE Bacterial Pathogens
The word ESKAPE denotes a particular group of microbial species viz., Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia,...
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High frequency and molecular epidemiology of metallo-β-lactamase-producing gram-negative bacilli in a tertiary care hospital in Lahore, Pakistan
BackgroundMetallo-β-lactamase (MBL)-producing isolates have a strong impact on diagnostic and therapeutic decisions. A high frequency of...
