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DR6 Augments Colorectal Cancer Cell Growth, Invasion, and Stemness by Activating AKT/NF-κB Pathway
This study aims to elucidate the role and mechanisms of Death Receptor 6 (DR6), a member of the tumor necrosis factor receptor superfamily, in the...
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The role of LOXL2 induced by glucose metabolism-activated NF-κB in maintaining drug resistance through EMT and cancer stemness in gemcitabine-resistant PDAC
AbstractGemcitabine is considered a standard treatment for pancreatic cancer, but develo** drug resistance greatly limits the effectiveness of...
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TC2N inhibits distant metastasis and stemness of breast cancer via blocking fatty acid synthesis
BackgroundTandem C2 domains, nuclear (TC2N) is a C2 domain-containing protein that belongs to the carboxyl-terminal type (C-type) tandem C2 protein...
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Exposure of piperlongumine attenuates stemness and epithelial to mesenchymal transition phenotype with more potent anti-metastatic activity in SOX9 deficient human lung cancer cells
Phytocompounds have shown hopeful results in cancer therapy. Piperlongumine (PIP), a naturally derived bioactive alkaloid found in our dietary spice,...
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USP51 promotes non-small cell lung carcinoma cell stemness by deubiquitinating TWIST1
BackgroundUSP51 is a deubiquitinase (DUB), that is involved in diverse cellular processes. Accumulating evidence has demonstrated that USP51...
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Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma
BackgroundAltered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the...
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Transition of amyloid/mutant p53 from tumor suppressor to an oncogene and therapeutic approaches to ameliorate metastasis and cancer stemness
The tumor suppressor p53 when undergoes amyloid formation confers several gain-of-function (GOF) activities that affect molecular pathways crucial...
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HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway
BackgroundHepatic inflammation is a common initiator of liver diseases and considered as the primary driver of hepatocellular carcinoma (HCC)....
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Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy
BackgroundThe mechanism of tumor immune escape and progression in colorectal cancer (CRC) is widely investigated in-vitro to help understand and...
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Protein homeostasis maintained by HOOK1 levels promotes the tumorigenic and stemness properties of ovarian cancer cells through reticulum stress and autophagy
BackgroundOvarian cancer has a high mortality rate mainly due to its resistance to currently used therapies. This resistance has been associated with...
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Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B
Cancer stem cells (CSCs) are a subpopulation of cancer cells endowed with high tumorigenic, chemoresistant and metastatic potential. Nongenetic...
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Therapeutics of Oxidative Stress and Stemness in Breast Cancer
Oxidative stress (OS) is induced by chemical reactions triggered inside our body by generation of reactive oxygen and nitrogen species and externally...
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Essential role of PLD2 in hypoxia-induced stemness and therapy resistance in ovarian tumors
BackgroundHypoxia in solid tumors is an important source of chemoresistance that can determine poor patient prognosis. Such chemoresistance relies on...
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m6A modified BACE1-AS contributes to liver metastasis and stemness-like properties in colorectal cancer through TUFT1 dependent activation of Wnt signaling
BackgroundLiver metastasis is one of the most important reasons for high mortality of colorectal cancer (CRC). Growing evidence illustrates that...
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Metformin abrogates Fusobacterium nucleatum-induced chemoresistance in colorectal cancer by inhibiting miR-361-5p/sonic hedgehog signaling-regulated stemness
BackgroundChemotherapy resistance is the major cause of recurrence in patients with colorectal cancer (CRC). A previous study found that Fusobacterium...
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BEX1 supports the stemness of hepatoblastoma by facilitating Warburg effect in a PPARγ/PDK1 dependent manner
BackgroundHepatoblastoma (HB) is a highly aggressive paediatric malignancy that exhibits a high presence of cancer stem cells (CSCs), which related...
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Integrated analysis of single-cell and bulk RNA sequencing data reveals a pan-cancer stemness signature predicting immunotherapy response
BackgroundAlthough immune checkpoint inhibitor (ICI) is regarded as a breakthrough in cancer therapy, only a limited fraction of patients benefit...
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Identification of prognostic stemness-related genes in kidney renal papillary cell carcinoma
BackgroundKidney renal papillary cell carcinoma (KIRP) is the second most prevalent malignant cancer originating from the renal epithelium. Nowadays,...
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RACGAP1 promotes the progression and poor prognosis of lung adenocarcinoma through its effects on the cell cycle and tumor stemness
ObjectionInvestigating the key genes and mechanisms that influence stemness in lung adenocarcinoma.
MethodsFirst, consistent clustering analysis was...
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FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling
BackgroundMetastasis of malignant tumors accelerates systemic failure and hastens the deaths of pancreatic cancer patients. During the metastatic...
