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NGS Analysis of Plasma cfDNA and cfmiRNA Signatures in Melanoma Brain Metastasis Patients
Cutaneous melanoma patients suffer from poor prognosis particularly when the disease has spread to the brain. Hence, it is critical the...
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Leprosy Vaccines: Developments for Prevention and Treatment
Over 200,000 new leprosy cases are reported globally every year. A vaccine for leprosy can eliminate the debilitating, biblical, and stigmatised...
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miRNA Dysregulation in Schizophrenia
Schizophrenia is a complex neuropsychiatric disorder that alters synapse activity as well as neural circuits. An intricate intracellular network of...
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A breathing mask attenuates acute airway responses to exercise in sub-zero environment in healthy subjects
PurposeCold air exposure is associated with increased respiratory morbidity and mortality. Repeated inhalation of cold and dry air is considered the...
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Clinical applications of metagenomics next-generation sequencing in infectious diseases
Infectious diseases are a great threat to human health. Rapid and accurate detection of pathogens is important in the diagnosis and treatment of...
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Immunotherapy: an emerging modality to checkmate brain metastasis
The diagnosis of brain metastasis (BrM) has historically been a dooming diagnosis that is nothing less than a death sentence, with few treatment...
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Neurotuberculosis: an update
Tuberculous (TB) meningitis (TBM), accounting for 70–80% of cases of neurotuberculosis, is one of the most severe forms of extrapulmonary...
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Pneumonia
Pneumonia is an acute lower respiratory tract infection affecting the bronchioles, alveoli, and distal airways. Such infections are primarily caused...
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Factors Influencing Collateral Circulation Formation After Indirect Revascularization for Moyamoya Disease: a Narrative Review
Indirect revascularization is one of the main techniques for the treatment of Moyamoya disease. The formation of good collateral circulation is a key...
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Multicenter Experience of Hematopoietic Stem Cell Transplantation in WHIM Syndrome
PurposeWHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome is a rare disease, caused by CXCR4 gene mutations, which...
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Hematopoietic Stem Cell Transplantation in ARPC1B Deficiency
Mutations in the ARPC1B isoform component of human actin-related protein 2/3 complex have been recently associated with an inborn error of immunity...
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Association of LAG3 genetic variation with an increased risk of PD in Chinese female population
BackgroundEmerging evidence suggests that α-synuclein (α-syn) aggregation and intercellular transmission contributes to pathogenesis of Parkinson’s...
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Neuroinflammatory Disease as an Isolated Manifestation of Hemophagocytic Lymphohistiocytosis
Isolated neuroinflammatory disease has been described in case reports of familial hemophagocytic lymphohistiocytosis (FHL), but the clinical spectrum...
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Associations of IL-17 and IL-17 receptor polymorphisms with Behçet’s disease in Denizli Province of Turkey
Although the etiopathogenesis of Behçet’s disease is not known, studies conducted in different populations show that it is a multifactorial disease...
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Impacts of CR1 genetic variants on cerebrospinal fluid and neuroimaging biomarkers in alzheimer’s disease
BackgroundThe complement component (3b/4b) receptor 1 gene ( CR1 ) gene has been proved to affect the susceptibility of Alzheimer’s disease (AD) in...
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Role of Tumour-Associated Macrophages in Colon Cancer Progression and Its Therapeutic Targeting
Cancer tissues are invariably infiltrated by cells of the immune system, and macrophages constitute the major portion of these. Experimental pieces...
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Iatrogenic Alzheimer’s disease in recipients of cadaveric pituitary-derived growth hormone
Alzheimer’s disease (AD) is characterized pathologically by amyloid-beta (Aβ) deposition in brain parenchyma and blood vessels (as cerebral amyloid...
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The Emerging Role of Toll-Like Receptor-Mediated Neuroinflammatory Signals in Psychiatric Disorders and Acquired Epilepsy
The new and evolving paradigms of psychiatric disorders pathogenesis are deeply inclined toward chronic inflammation that leads to disturbances in...
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Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
BackgroundAbout 25% of patients with acute hepatitis C virus (HCV) infection show spontaneous clearance within the first six months of infection but...
