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1. Exploring the mechanism of Icariin in the treatment of depression through BDNF-TrkB pathway based on network pharmacology

   Depression has increasingly become a disease that seriously harms people’s mental health around the world. Icariin is the main active component of Epim...

   **aoke Di, Meiyu Wan, ... Yang Li in Naunyn-Schmiedeberg's Archives of Pharmacology

   Article 20 July 2023
   

2. Transcription Factors and Signal Transduction

   In this chapter, we will present transcription factors as the key controllers of gene expression. The activities of these proteins critically...

   Carsten Carlberg, Eunike Velleuer, Ferdinand Molnár in Molecular Medicine

   Chapter 2023
   

3. Role of HIF-1 in Brain Tumor Development

   HIFs are the transcription factors which respond to the low oxygen concentration in the cellular environment of hypoxia (Smith et al. 2008; Wilkins...

   Mehdi Hayat Shahi in Role of Signaling Pathways in Brain Tumorigenesis

   Chapter 2023
   

4. Harm of circadian misalignment to the hearts of the adolescent wistar rats

   Purpose

   The purpose of this study was to observe the harm of circadian misalignment (CM), caused by an inverted photoperiod (IP), on the hearts of the...

   YunLei Wang, YuanYuan Hou, ... Tong Zhang in Journal of Translational Medicine

   Article Open access 06 August 2022
   

5. Bioinformatics Analysis and Identification of Ferroptosis-Related Hub Genes in Intervertebral Disc Degeneration

   Approximately 80% of individuals encounter lower back pain (LBP), a prevalent clinical issue largely attributed to intervertebral disc degeneration...

   Feng Jiang, **nxin Li, ... Yuntao Wang in Biochemical Genetics

   Article 16 December 2023
   

6. Ubiquitination and deubiquitination in the regulation of N⁶-methyladenosine functional molecules

   N ⁶ methyladenosine (m ⁶ A) is the most prevalent RNA epigenetic modification, regulated by methyltransferases and demethyltransferases and recognized...

   Yue Zhao, Jiaojiao Huang, ... Shengjun Wang in Journal of Molecular Medicine

   Article 30 January 2024
   

7. Osteoarthritis related epigenetic variations in miRNA expression and DNA methylation

   Osteoarthritis (OA) is chronic arthritis characterized by articular cartilage degradation. However, a comprehensive regulatory network for OA-related...

   Lingpeng **, Jun Ma, ... Jiangtao Dong in BMC Medical Genomics

   Article Open access 11 July 2023
   

8. Extracellular Signal-Regulated Kinases, Models of

   Susana R. Neves in Encyclopedia of Computational Neuroscience

   Reference work entry 2022
   

9. RETRACTED ARTICLE: Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia

   Background

   As a form of dementia primarily affecting the elderly, vascular dementia (VD) is characterized by changes in the supply of blood to the...

   **n-Rui Han, **n Wen, ... Yuan-Lin Zheng in Molecular Medicine

   Article Open access 03 May 2018
   

10. The superficial zone of articular cartilage

    The superficial zone of articular cartilage contributes to smooth joint motion through the production of proteoglycan 4 (PRG4), also known as...

    Taku Saito in Inflammation and Regeneration

    Article Open access 02 May 2022
    

11. MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

    MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with...

    Mahboobeh Faramin Lashkarian, Nasrin Hashemipour, ... Seyed Mohsen Aghaei-Zarch in Cancer Cell International

    Article Open access 20 February 2023
    

12. Stiff tumours exhaust T cells

    Lucy Bird in Nature Reviews Immunology

    Article 31 May 2024

13. Specific expression profile of follicular fluid-derived exosomal microRNAs in patients with diminished ovarian reserve

    Background

    Diminished ovarian reserve (DOR) is defined as a reduction in ovarian reserve and oocyte quality. The pathophysiology of DOR has not been...

    Kai-Yuan Shen, **ao-Li Dai, ... **ao-Li Qu in BMC Medical Genomics

    Article Open access 30 November 2023
    

14. Angiomatoid fibrous histiocytoma: an atypical brain location newly described as intracranial mesenchymal tumor FET-CREB fusion-positive

    Leslie Lemnos, Henri Salle, ... Mathilde Duchesne in Acta Neurologica Belgica

    Article 06 May 2022
    

15. Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells

    Background

    Albuterol is the first-line asthma medication used in diverse populations. Although DNA methylation (DNAm) is an epigenetic mechanism...

    Javier Perez-Garcia, Maria Pino-Yanes, ... Esteban G. Burchard in Clinical Epigenetics

    Article Open access 03 October 2023
    

16. Ocular and neural genes jointly regulate the visuospatial working memory in ADHD children

    Objective

    Working memory (WM) deficits have frequently been linked to attention deficit hyperactivity disorder (ADHD). Despite previous studies...

    Yilu Zhao, Yuanxin Zhong, ... Li Yang in Behavioral and Brain Functions

    Article Open access 01 September 2023
    

17. Gene regulation in activated microglia by adenosine A₃ receptor agonists: a transcriptomics study

    Most neurodegenerative disorders, including the two most common, Alzheimer’s disease (AD) and Parkinson’s disease (AD), course with activation of...

    Alejandro Lillo, Joan Serrano-Marín, ... Rafael Franco in Purinergic Signalling

    Article Open access 27 January 2023
    

18. Gene-environment regulatory circuits of right ventricular pathology in tetralogy of fallot

    Abstract

    The phenotypic spectrum of congenital heart defects (CHDs) is contributed by both genetic and environmental factors. Their interactions are...

    Yan Zhao, Xuedong Kang, ... Yibin Wang in Journal of Molecular Medicine

    Article 13 December 2019
    

19. miR-34a-5p as molecular hub of pathomechanisms in Huntington’s disease

    Background

    Although a pivotal role of microRNA (miRNA, miR) in the pathogenesis of Huntington’s disease (HD) is increasingly recognized, the molecular...

    Martin Hart, Caroline Diener, ... Eckart Meese in Molecular Medicine

    Article Open access 03 April 2023
    

20. rs2072580T>A Polymorphism in the Overlap** Promoter Regions of the SART3 and ISCU Genes Associated with the Risk of Breast Cancer

    We analyzed association of potentially regulatory polymorphisms ( rs590352 , rs11542583 , rs3829202 , rs207258 , and rs4796672 ) with breast cancer. A...

    A. O. Degtyareva, E. Y. Leberfarb, ... T. I. Merkulova in Bulletin of Experimental Biology and Medicine

    Article 01 May 2020