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A CNV Catalogue
Rapid incorporation of microarray analysis/aCGHArray CGH (aCGH) for studies of children with developmental disabilities and its endorsement as a...
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Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an...
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Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent....
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An analysis of the association between prostate cancer risk loci, PSA levels, disease aggressiveness and disease-specific mortality
Background:Genome-wide association studies have identified multiple single-nucleotide polymorphsims (SNPs) associated with prostate cancer (PCa)....
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Germline mutations predisposing to non-small cell lung cancer
Lung cancer in multiple first degree relatives had previously been attributed to smoking and to inherited enzymes associated with increased...
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Correlation of CLPTM1L polymorphisms with lung cancer susceptibility and response to cisplatin-based chemotherapy in a Chinese Han population
The implication of genetic factors in predisposition to cancer is a recognized fact. The Cleft lip and palate transmembrane 1-like ( CLPTM1L ) gene...
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Triple-negative breast cancer in African-American women: disparities versus biology
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately affects BRCA1 mutation carriers and young women...
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A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia
Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable...
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Multiplex ligation-dependent probe amplification and array comparative genomic hybridization analyses for prenatal diagnosis of cytogenomic abnormalities
BackgroundThe aims of this study were to evaluate the clinical utility of multiplex ligation-dependent probe amplification (MLPA) and array...
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Generation of BAC Transgenic Mice for Functional Analysis of Neural Circuits
Functional analysis of neural circuits in the living brain is an exceptional challenge that has been greatly advanced in the modern molecular...
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Quantitative assessment of common genetic variants on chromosome 5p15 and lung cancer risk
Several genome-wide association studies on lung cancer (LC) have reported similar findings of a new susceptibility locus, 5p15. After that, a number...
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Increased lung cancer risk associated with the TERT rs2736100 polymorphism: an updated meta-analysis
The rs2736100 polymorphism in the telomerase reverse transcriptase ( TERT ) gene has been implicated in lung cancer risk in multiple populations, but...
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Lung cancer risk and genetic variants in East Asians: a meta-analysis
Inconsistent results are often found regarding the risk of genetic variants in lung cancer association studies. To alleviate these conflicts, we...
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Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity
Urothelial carcinoma of the bladder comprises two long-recognized disease entities with distinct molecular features and clinical outcome. Low-grade...
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Association between TERT rs2736100 polymorphism and lung cancer susceptibility: evidence from 22 case–control studies
The 5p15.33 locus has been recently identified to associate with multiple cancer types including lung, urinary bladder, prostate, and cervical...
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Familial testicular germ cell tumor: no associated syndromic pattern identified
BackgroundTesticular germ cell tumor (TGCT) is the most common malignancy in young men. Familial clustering, epidemiologic evidence of increased risk...
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Melanoma Susceptibility Genes and Risk Assessment
Familial melanoma accounts for approximately a tenth of all melanoma cases. The most commonly known melanoma susceptibility gene is the highly...
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A fast multilocus test with adaptive SNP selection for large-scale genetic-association studies
As increasing evidence suggests that multiple correlated genetic variants could jointly influence the outcome, a multilocus test that aggregates...
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LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk
Background:Aberrant global DNA methylation is shown to increase cancer risk. LINE-1 has been proven a measure of global DNA methylation. The...
