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Impaired migratory phenotype of CD4+ T cells in Parkinson’s disease
Dysfunctions in the immune system appear implicated in both disease onset and progression of Parkinson’s disease (PD). Neurodegeneration observed in...
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CXCR5+PD-1++ CD4+ T cells colonize infant intestines early in life and promote B cell maturation
Gastrointestinal infections are a major cause for serious clinical complications in infants. The induction of antibody responses by B cells is...
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Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissue
The study of HIV infection and pathogenicity in physical reservoirs requires a biologically relevant model. The human immune system (HIS) mouse is an...
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T Cell Subsets and Immune Homeostasis
T cells are a heterogeneous group of cells that can be classified into different subtypes according to different classification methods. The body’s...
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CTLA4 protects against maladaptive cytotoxicity during the differentiation of effector and follicular CD4+ T cells
As chronic antigenic stimulation from infection and autoimmunity is a feature of primary antibody deficiency (PAD), analysis of affected patients...
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Comprehensive Analysis of the miRNA-mRNA Pathological Regulatory Network of Intestinal CD4 + T Cells in Parkinson’s Disease
Infiltration of CD4 + T cells was found in brain tissue samples from PD patients, suggesting their involvement in develo** central nervous system...
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Adoptive Transfer of Cryptococcus neoformans-Specific CD4 T-Cells to Study Anti-fungal Lymphocyte Responses In Vivo
CD4 T-cells are important for long-term control and clearance of several fungal infections in humans, particularly those caused by Cryptococcus...
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Establishment and recall of SARS-CoV-2 spike epitope-specific CD4+ T cell memory
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination elicit CD4 + T cell responses to the spike protein, including...
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Regulatory T-Cells Methods and Protocols
This volume provides methods and models for investigating the immunosuppressive subset of CD4+ T-cells, regulatory T-cells (Treg). Chapters guide...
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Regulation of c-SMAC formation and AKT-mTOR signaling by the TSG101-IFT20 axis in CD4+ T cells
CD4 + T cells play major roles in the adaptive immune system, which requires antigen recognition, costimulation, and cytokines for its elaborate...
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Generation of Murine T Cell Effector Populations In Vitro
Expansion of T cell subsets in vitro is a valuable tool for exploration of effector function and differentiation. Here we provide protocols for in...
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Trimodal single-cell profiling reveals a novel pediatric CD8αα+ T cell subset and broad age-related molecular reprogramming across the T cell compartment
Age-associated changes in the T cell compartment are well described. However, limitations of current single-modal or bimodal single-cell assays,...
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mTOR pathway mediates endoplasmic reticulum stress-induced CD4+ T cell apoptosis in septic mice
Endoplasmic reticulum stress (ERS) has been well documented to participate in the pathophysiological processes of apoptosis in many diseases....
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Establishing a whole blood CD4+ T cell immunity measurement to predict response to anti-PD-1
BackgroundBiomarkers that can accurately predict the efficacy of immune checkpoint inhibitors (ICIs) against programmed death 1 (PD-1) ligand in...
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CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation
Objectivec-Met, a tyrosine kinase receptor, is the unique receptor for hepatocyte growth factor (HGF). The HGF/c-Met axis is reported to modulate...
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Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation
During activation, T cells undergo extensive gene expression changes that shape the properties of cells to exert their effector function....
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High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro
IntroductionThe humanized anti-α4 integrin blocking antibody natalizumab (NTZ) is an effective treatment for relapsing–remitting multiple sclerosis...
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Inhibition of CD4 + T cells by fanchinoline via miR506-3p/NFATc1 in Sjögren’s syndrome
The hyperproliferation and hyperactivation of CD4 + T cells in salivary gland tissues are hallmarks of Sjögren’s syndrome (SS). Fangchinoline (Fan)...
