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Tiagabine and zonisamide differentially regulate the glial properties in an astrocyte-microglia co-culture model of inflammation
Due to the role of astrocytes and microglia in the pathophysiology of epilepsy and limited studies of antiseizure medication (ASM) effects on glial...
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Beneficial effects of levetiracetam in streptozotocin-induced rat model of Alzheimer’s disease
Alzheimer’s disease (AD) is the most common neurodegenerative disorder among the elderly. In the light of increasing AD prevalence and lack of...
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Evaluation of CYP2C19 activity using microdosed oral omeprazole in humans
PurposeTo investigate the suitability of microdosed oral omeprazole for predicting CYP2C19 activity in vivo in combination with simultaneous...
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Ketamine in seizure management and future pharmacogenomic considerations
Ketamine is a noncompetitive N -methyl- D -aspartate antagonist with emerging evidence for use in medically refractory epilepsy. We describe the novel...
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Targeting synapse function and loss for treatment of neurodegenerative diseases
Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate with cognitive decline. However, the mechanisms and...
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Design and synthesis of novel cycloalkanecarboxamide parabanic acid hybrids as anticonvulsants
Aiming to develop novel anticonvulsant agents a new series of novel cycloalkanecarboxamide parabanic acid hybrids series 8 , 9 and 10 possessing the...
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Unexpected beneficial effects of drugs: an analysis of cases in the Dutch spontaneous reporting system
IntroductionDrug use is inherently related to both beneficial effects on health as well as the occurrence of risks. The beneficial effects may be...
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Molecular Genetic Techniques in Biomarker Analysis Relevant for Drugs Centrally Approved in Europe
On the basis of scientific evidence, information on the option, recommendation or requirement to test for pharmacogenetic or pharmacogenomic...
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Epilepsy and COVID-19: Management of Patients and Optimization of Antiepileptic Treatment in the Pandemic
There are as yet no data pointing to any increase in the incidence of the novel coronavirus infection (COVID-19) or a more severe course of illness...
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Drug Interactions
Drug-drug interactions (DDIs) are considered as change of drug-related effects due to the simultaneous administration of another drug. As a...
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Drug Interactions
Drug-drug interactions (DDIs) are considered as change of drug-related effects due to the simultaneous administration of another drug. As a...
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State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References
The Biopharmaceutics Drug Disposition Classification system (BDDCS) is a four-class approach based on water solubility and extent of...
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Improving Tabletability of Excipients by Metal-Organic Framework-Based Cocrystallization: a Study of Mannitol and CaCl2
PurposeTo improve tabletability of pharmaceutical excipient mannitol by forming cocrystal with metal-organic framework (MOF) structure.
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Cannabidiol Therapy for Refractory Epilepsy and Seizure Disorders
Cannabis-derived cannabinoids have neuroactive properties. Recently, there has been emerging interest in the use of cannabidiol (CBD)-enriched...
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A novel PAK1 variant causative of neurodevelopmental disorder with postnatal macrocephaly
p21-activated kinases (PAKs) are protein serine/threonine kinases stimulated by Rho-family p21 GTPases such as CDC42 and RAC. PAKs have been...
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The Toxicology Investigators Consortium 2022 Annual Report
Since 2010, medical toxicology physicians from the American College of Medical Toxicology (ACMT) Toxicology Investigators Consortium (ToxIC) have...
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Global distribution of CYP2C19 risk phenotypes affecting safety and effectiveness of medications
Genetic variability of CYP2C19 may affect safety or efficacy of many clinically important medications as outlined in the clinical pharmacogenetics...
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Multi-disciplinary Approach for Drug and Gene Delivery Systems to the Brain
Drug delivery into the brain has for long been a huge challenge as the blood–brain barrier (BBB) offers great resistance to entry of foreign...
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Antiepileptic drug therapy in the elderly: a clinical pharmacological review
Seizure disorder is the third most common neurological disorder in the elderly after stroke and dementia. With the increasing geriatric population,...