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Personalized neoantigen vaccine prevents postoperative recurrence in hepatocellular carcinoma patients with vascular invasion
BackgroundClinically, prophylactic anti-recurrence treatments for hepatocellular carcinoma (HCC) patients after radical surgery are extremely...
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A 38-gene model comprised of key TET2-associated genes shows additive utility to high-risk prostate cancer cases in the prognostication of biochemical recurrence
BackgroundEarly treatment of patients at risk for develo** aggressive prostate cancer is able to delay metastasis and reduce mortality; as such,...
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Potential values of circulating tumor cell for detection of recurrence in patients of thyroid cancer: a diagnostic meta-analysis
BackgroundSeveral studies have reported that circulating tumor cells (CTCs) are a promising marker for the diagnosis of thyroid cancer (TC) with...
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Roles of Cancer Stem Cells in Therapy Resistance and Disease Recurrence
Cancer stem cells (CSCs), which can self-renew and differentiate into different kinds of cancer cells, are suggested to be responsible for drug...
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Perspectives in Biochemical Staging of Hepatocellular Carcinoma Over the Current Microscopical Methodology
Hepatocellular carcinoma (HCC) is considered the third main cause of cancer-related deaths globally. Comparing with other tumors, survival of HCC...
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Geraniol accelerates the gastric healing, minimizes ulcers recurrence, and reduces anxiolytic-like behavior in ulcerated rodents by oral or inhaled route
BackgroundGeraniol (GE) is dietary acyclic monoterpene alcohol found in essential oils from aromatic plants with therapeutic value against gastric...
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Phase III randomised controlled trial on PSMA PET/CT guided hypofractionated salvage prostate bed radiotherapy of biochemical failure after radical prostatectomy for prostate cancer (PERYTON-trial): study protocol
BackgroundSalvage external beam radiotherapy (sEBRT) for patients with a biochemical recurrence (BCR) after radical prostatectomy provides a 5-year...
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Prognostic significance of AKR1C4 and the advantage of combining EBV DNA to stratify patients at high risk of locoregional recurrence of nasopharyngeal carcinoma
BackgroundDistinguishing patients at a greater risk of recurrence is essential for treating locoregional advanced nasopharyngeal carcinoma (NPC)....
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Prognostic value of 17-Gene genomic prostate score in patients with clinically localized prostate cancer: a meta-analysis
BackgroundThe 17-gene Genomic Prostate Score (GPS) test has been clinically employed to predict adverse prognosis in prostate cancer. In this...
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Neurofilament Light Chain in the Blood As Biochemical Markers in the Critically Ill
Neurofilament light chain (NfL) is a protein of the neuronal cytoskeleton and a biochemical marker specific for neuroaxonal damage when released and...
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Exploratory cost-effectiveness analysis of 68Gallium-PSMA PET/MRI-based imaging in patients with biochemical recurrence of prostate cancer
Men treated for prostate cancer with curative intent face a recurrence rate of up to 53% at 10 years. 68 Ga-PSMA imaging is a new technique that can...
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AFP and eGFR are related to early and late recurrence of HCC following antiviral therapy
BackgroundAn unexpected recurrence of hepatocellular carcinoma (HCC) sometimes occurs in patients with hepatitis C virus (HCV) after treatment with...
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Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival
BackgroundWhile cellular metabolism and acidic waste handling accelerate during breast carcinogenesis, temporal patterns of acid–base regulation and...
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A pre-specified model based on four kallikrein markers in blood improves predictions of adverse pathology and biochemical recurrence after radical prostatectomy
BackgroundA pre-specified model based on four kallikrein markers in blood, commercially available as 4Kscore, predicts Gleason Grade (GG) 3 + 4 or...
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Effect of aspirin on incidence, recurrence, and mortality in prostate cancer patients: integrating evidence from randomized controlled trials and real-world studies
PurposeAspirin has been suggested to reduce the risk of cancer. However, previous studies have been inconsistent regarding the relationship between...
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Metformin and Dapagliflozin Attenuate Doxorubicin-Induced Acute Cardiotoxicity in Wistar Rats: An Electrocardiographic, Biochemical, and Histopathological Approach
Doxorubicin is a widely used anticancer drug whose efficacy is limited due to its cardiotoxicity. There is no ideal cardioprotection available...
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Impact of preoperative antiviral therapy on the prognosis of hepatitis B virus-related hepatocellular carcinoma
BackgroundFor chronic hepatitis B virus (HBV) infection patients, increasing evidence has demonstrated the effectiveness of expanding the indications...
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Genomic classifiers and prognosis of localized prostate cancer: a systematic review
BackgroundRefinement of the risk classification for localized prostate cancer is warranted to aid in clinical decision making. A systematic analysis...
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Testosterone therapy does not increase the risks of prostate cancer recurrence or death after definitive treatment for localized disease
BackgroundThe safety of testosterone therapy (TT) after definitive treatment for localized prostate cancer remains undefined. We analyzed the risks...