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Diving ergospirometry with suspended weights: breathing- and fin-swimming style matter
PurposeScuba diving is a complex condition including elevated ambient pressure, limited air supply, increased breathing work, and unfamiliar...
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Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey
Accurate prediction of human clearance (CL) and volume of distribution at steady state (V d,ss ) for small molecule drug candidates is an essential...
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Moving a missing hand: children born with below elbow deficiency can enact hand grasp patterns with their residual muscles
Children with a unilateral congenital below elbow deficiency (UCBED) have one typical upper limb and one that lacks a hand, ending below the elbow at...
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From hazard to risk prioritization: a case study to predict drug-induced cholestasis using physiologically based kinetic modeling
Cholestasis is characterized by hepatic accumulation of bile acids. Clinical manifestation of cholestasis only occurs in a small proportion of...
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Navigation and the efficiency of spatial coding: insights from closed-loop simulations
Spatial learning is critical for survival and its underlying neuronal mechanisms have been studied extensively. These studies have revealed a wealth...
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Adversarial attacks and adversarial training for burn image segmentation based on deep learning
AbstractDeep learning has been widely applied in the fields of image classification and segmentation, while adversarial attacks can impact the...
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Evaluation of the model malaria elimination strategy in Mandla district along with its neighbouring districts: a time series analysis from 2008 to 2020
BackgroundCompared to 2017, India achieved a significant reduction in malaria cases in 2020. Madhya Pradesh (MP) is a tribal dominated state of India...
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SleepBoost: a multi-level tree-based ensemble model for automatic sleep stage classification
Neurodegenerative diseases often exhibit a strong link with sleep disruption, highlighting the importance of effective sleep stage monitoring. In...
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Acute Mechanical Consequences of Vessel-Specific Coronary Bypass Combinations
PurposePremature coronary artery bypass graft (CABG) failure has been linked to geometric, mechanical, and compositional discrepancies between host...
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Gray-to-color image conversion in the classification of breast lesions on ultrasound using pre-trained deep neural networks
AbstractBreast ultrasound (BUS) image classification in benign and malignant classes is often based on pre-trained convolutional neural networks...
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Robust thalamic nuclei segmentation from T1-weighted MRI using polynomial intensity transformation
Accurate segmentation of thalamic nuclei, crucial for understanding their role in healthy cognition and in pathologies, is challenging to achieve on...
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A comparison of misoprostol with and without methylergometrine and oxytocin in outpatient medical abortion: a phase III randomized controlled trial
ObjectiveThe complications associated with miscarriages have surfaced as a major concern in maintaining women’s physical and mental health. The...
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An Experimental and Computational Approach to Development of Mixing Processes for Miscible Liquids in Unbaffled Tanks
PurposeMixing of liquids is a critical unit operation in the biopharmaceutical drug product manufacturing. It commonly consists of mixing miscible...
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Post-stroke hand gesture recognition via one-shot transfer learning using prototypical networks
BackgroundIn-home rehabilitation systems are a promising, potential alternative to conventional therapy for stroke survivors. Unfortunately,...
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Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma
The phase 3 ZUMA-7 trial in second-line large B cell lymphoma demonstrated superiority of anti-CD19 CAR T cell therapy (axicabtagene ciloleucel...
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Convolutional Neural Networks Enable Highly Accurate and Automated Subvisible Particulate Classification of Biopharmaceuticals
Quantification of subvisible particles, which are generally defined as those ranging in size from 2 to 100 µm, is important as critical...
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Prognostic relevance of HRDness gene expression signature in ovarian high-grade serous carcinoma; JGOG3025-TR2 study
BackgroundThis study aimed to evaluate the homologous recombination repair pathway deficiency (HRD) in ovarian high-grade serous carcinoma (HGSC).
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Three Critical Elements of Start-Up Success
Compared to the already complex and difficult pathway to market for innovative start-ups, innovators in forensic sciences face additional challenges...
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mResU-Net: multi-scale residual U-Net-based brain tumor segmentation from multimodal MRI
Brain tumor segmentation is an important direction in medical image processing, and its main goal is to accurately mark the tumor part in brain MRI....
