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Nanoparticles of conformation-stabilized canine distemper virus hemagglutinin are highly immunogenic and induce robust immunity
BackgroundCanine distemper virus (CDV) infection of ferrets, dogs, and giant pandas causes an acute systemic disease involving multiple organ...
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Deletion of a decoy epitope in porcine circovirus 2 (PCV2) capsid protein affects the protective immune response in mice
The swine pathogen porcine circovirus type 2 (PCV2) causes significant economic damage worldwide. The PCV2 capsid (CP) residues 169-STIDYFQPNNKR-180...
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Functional Analysis of Sulfatide in Influenza A Virus Infection and Replication
3-O-sulfation synthesizes sulfatide in the galactose moiety of galactosylceramide. Sulfatide is expressed in many organs such as the gastrointestinal...
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Expression of influenza A virus-derived peptides on a rotavirus VP6-based delivery platform
Recombinant protein technology enables the engineering of modern vaccines composed of a carrier protein displaying poorly immunogenic heterologous...
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A virus like particle approach to study the Chikungunya virus envelope protein mutations
Virus like particles (VLPs) are used as a tool to study the mutations in the structural genes that influence the virus assembly and entry process. We...
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A Surface Plasmon Resonance-Based Strategy to Characterize Interactions of NLR Proteins with Associated Factors
NOD-like receptors (NLRs) are established as key regulators of the innate immune system. In recent years, an increasing number of interaction...
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Cloning, baculoviral expression, detergent optimization and purification of human serotonin 5-HT2A G-protein-coupled receptor
The serotonin 5-HT 2A receptor is a member of G-protein-coupled receptor (GPCR) superfamily. Human 5-HT 2A (hu5-HT 2A ) receptor is broadly distributed...
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Virus matrix interference on assessment of virucidal activity of high-touch surfaces designed to prevent hospital-acquired infections
Objectives/purposeHigh-touch surfaces are a critical reservoir in the spread of nosocomial infections. Although disinfection and infection control...
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Viral Tools for Neural Circuit Tracing
Neural circuits provide an anatomical basis for functional networks. Therefore, dissecting the structure of neural circuits is essential to...
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The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate
BackgroundControl and elimination of malaria can be accelerated by transmission-blocking interventions such as vaccines. A surface antigen of Plasmodi...
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3H-31, A Non-structural Protein of Heliothis virescens ascovirus 3h, Inhibits the Host Larval Cathepsin and Chitinase Activities
3h-31 of Heliothis virescens ascovirus 3h (HvAV-3h) is a highly conserved gene of ascoviruses. As an early gene of HvAV-3h, 3h-31 codes for a...
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Autographa Californica Multiple Nucleopolyhedrovirus orf13 Is Required for Efficient Nuclear Egress of Nucleocapsids
Autographa californica multiple nucleopolyhedrovirus (AcMNPV) orf13 ( ac13 ) is a conserved gene in all sequenced alphabaculoviruses. However, its...
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Cell-line-dependent crystal morphology and sublocalization of the Thyrinteina arnobia cypovirus polyhedrin expressed from a recombinant baculovirus
We describe an unexpected feature observed for the heterologous expression of the Thyrinteina arnobia cypovirus polyhedrin from a recombinant...
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VLPs containing stalk domain and ectodomain of matrix protein 2 of influenza induce protection in mice
BackgroundAs a result of antigenic drift, current influenza vaccines provide limited protection against circulating influenza viruses, and vaccines...
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Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
Dipeptidyl peptidase-4 (DPP4) plays a crucial role in regulating the bioactivity of glucagon-like peptide-1 (GLP-1) that enhances insulin secretion...
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Generation and immunogenicity of virus-like particles based on mink enteritis virus capsid protein VP2 expressed in Sf9 cells
Mink enteritis virus (MEV) is a parvovirus that causes acute enteritis in mink. The capsid protein VP2 of MEV is a major immunogenicity that is...
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Hepatitis B virus virion secretion is a CRM1-spike-mediated late event
BackgroundHepatitis B virus (HBV) is a major human pathogen worldwide. To date, there is no curative treatment for chronic hepatitis B. The mechanism...
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PF-D-Trimer, a protective SARS-CoV-2 subunit vaccine: immunogenicity and application
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had and continues to have a significant impact on global public health. One of the...
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Optimization of viral protein ratios for production of rAAV serotype 5 in the baculovirus system
Recombinant adeno-associated virus (rAAV) has become the vector of choice for the development of novel human gene therapies. High-yield manufacturing...
