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CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis
BackgroundFerroptosis is a novel form of iron-dependent cell death and participates in the malignant progression of glioblastoma (GBM). Although...
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3, 3,5 and 2,6 Expanded Aza-BODIPYs Via Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions: Synthesis and Photophysical Properties
Novel symmetrical aza-borondipyrromethene (aza-BODIPY) compounds bearing 4-methoxyphenyl, 4-methoxybiphenyl, 2,4-dimethoxybipheny, 4-bromophenyl and...
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Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling
BackgroundTriple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking effective targeted therapies, necessitating innovative...
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Macropinocytosis is an alternative pathway of cysteine acquisition and mitigates sorafenib-induced ferroptosis in hepatocellular carcinoma
BackgroundMacropinocytosis, an important nutrient-scavenging pathway in certain cancer cells, allows cells to compensate for intracellular amino acid...
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Methylated Unsymmetric BODIPY Compounds: Synthesis, High Fluorescence Quantum Yield and Long Fluorescence Time
We show that unsymmetric BODIPY compounds with one, two, and three methyl groups can be synthesized easily and efficiently by the unsymmetric...
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Norbormide-Based Probes and Their Application for Mitochondrial Imaging in Drosophila Melanogaster
Fluorescent live imaging on Drosophila melanogaster is a microscopy technique in rapid expansion. The growing number of probes available to detect...
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Deficiency of SDHC promotes metastasis by reprogramming fatty acid metabolism in colorectal cancer
BackgroundSeveral studies have demonstrated a strong correlation between impaired Succinate dehydrogenase (SDH) function and the advancement of...
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A Light in the Dark: Uncovering Wolbachia-Host Interactions Using Fluorescence Imaging
The success of microbial endosymbionts, which reside naturally within a eukaryotic “host” organism, requires effective microbial interaction with,...
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Divergence exists in the subcellular distribution of intramuscular triglyceride in human skeletal muscle dependent on the choice of lipid dye
Despite over 50 years of research, a comprehensive understanding of how intramuscular triglyceride (IMTG) is stored in skeletal muscle and its...
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Identification and validation of a novel prognostic signature based on mitochondria and oxidative stress related genes for glioblastoma
BackgroundMitochondria represent a major source of reactive oxygen species (ROS) in cells, and the direct increase in ROS content is the primary...
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SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism
BackgroundCigarette smoking (CS) is a strong risk factor for idiopathic pulmonary fibrosis (IPF). It can activate lung fibroblasts (LF) by inducing...
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Synthesis and Spectral Characteristics of BODIPY Dyes with Two or Three Dipyrrin Domains
Several boron-dipyrrin (BODIPY) based fluorophores with two and three dipyrrin cores were synthesized and investigated in solvents under the...
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Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis
BackgroundTargeting ferroptosis has been identified as a promising approach for the development of cancer therapies. Monounsaturated fatty acid...
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Assessment of Imaging Flow Cytometry for the Simultaneous Discrimination of Protein Particles and Silicone Oil Droplets in Biologicals
PurposeSilicone oil droplets in biopharmaceutical products can originate from sources such as siliconized surfaces of primary packaging materials,...
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Lipid droplet accumulation mediates macrophage survival and Treg recruitment via the CCL20/CCR6 axis in human hepatocellular carcinoma
Metabolic changes play a crucial role in determining the status and function of macrophages, but how lipid reprogramming in macrophages contributes...
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Pharmacological Upregulation of Microglial Lipid Droplet Alleviates Neuroinflammation and Acute Ischemic Brain Injury
Lipid droplets (LDs) were reported to play an important role in the modulation of inflammation and various cellular processes among multiple cell...
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Measurement of Intracellular Temperature in Brown Adipocytes Using a Cationic Fluorescent Polymeric Thermometer
Brown adipose tissue specializes in expending energy through non-shivering thermogenesis, and many studies have associated its activity with...
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miR-223 accelerates lipid droplets clearance in microglia following spinal cord injury by upregulating ABCA1
BackgroundSpinal cord injury (SCI) is characterized by extensive demyelination and inflammatory responses. Facilitating the clearance of lipid...
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Fluorescent Organic Molecules as Diagnostic and Theranostic Tools for Alzheimer’s Disease
Diagnosis of Alzheimer’s disease (AD) is crucial especially for the complete comprehension of pathology and clinical therapy of the disorder, as well...
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Microglial ferroptotic stress causes non-cell autonomous neuronal death
BackgroundFerroptosis is a form of regulated cell death characterised by lipid peroxidation as the terminal endpoint and a requirement for iron....
