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How germ granules promote germ cell fate
Germ cells are the only cells in the body capable of giving rise to a new organism, and this totipotency hinges on their ability to assemble...
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Live Cell Imaging of Dynamic Processes in Adult Zebrafish Retinal Cross-Section Cultures
Following retinal injury, zebrafish possess the remarkable capacity to endogenously regenerate lost retinal neurons from Müller glia-derived neuronal...
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Mitochondrial genetics through the lens of single-cell multi-omics
Mitochondria carry their own genetic information encoding for a subset of protein-coding genes and translational machinery essential for cellular...
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LRRC10 regulates mammalian cardiomyocyte cell cycle during heart regeneration
Leucine-rich repeat containing 10 (LRRC10) is a cardiomyocyte-specific protein, but its role in cardiac biology is little understood. Recently Lrrc10...
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New insights into the epitranscriptomic control of pluripotent stem cell fate
Each cell in the human body has a distinguishable fate. Pluripotent stem cells are challenged with a myriad of lineage differentiation options....
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SREBP signaling is essential for effective B cell responses
Our previous study using systems vaccinology identified an association between the sterol regulatory binding protein (SREBP) pathway and humoral...
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CD4+ T cell memory
Specialized subpopulations of CD4 + T cells survey major histocompatibility complex class II–peptide complexes to control phagosomal infections, help...
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Endogenous Neural Stem Cell–induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives
Ischemic stroke is a very common cerebrovascular accident that occurred in adults and causes higher risk of neural deficits. After ischemic stroke,...
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Cell Migration in the Mammalian Cortex
One of the hallmarks of the develo** central nervous system (CNS) is the migration of diverse newly born cells from embryonic germinal regions to...
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Cell Migration in the Mammalian Cortex
One of the hallmarks of the develo** central nervous system (CNS) is the migration of diverse newly born cells from embryonic germinal regions to...
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Harnessing cancer stem cell-derived exosomes to improve cancer therapy
Cancer stem cells (CSCs) are the key “seeds” for tumor initiation and development, metastasis, and recurrence. Because of the function of CSCs in...
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Identification of a novel lymphangiogenesis signature associated with immune cell infiltration in colorectal cancer based on bioinformatics analysis
BackgroundLymphangiogenesis plays an important role in tumor progression and is significantly associated with tumor immune infiltration. However, the...
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Cellular metabolism regulates the differentiation and function of T-cell subsets
T cells are an important component of adaptive immunity and protect the host from infectious diseases and cancers. However, uncontrolled T cell...
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Cell fate determination and Hippo signaling pathway in preimplantation mouse embryo
First cell fate determination plays crucial roles in cell specification during early phases of embryonic development. Three classical concepts have...
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Biology, Chemistry, and Physics of Cancer Cell Motility and Metastasis
A malignant tumor has ability to invade the nearby tissues and colonize distant sites (organs) through the lymphatic/vascular system. From...
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Loss of ndrg2 Function Is Involved in Notch Activation in Neuromast Hair Cell Regeneration in Zebrafish
The regeneration of hair cells in zebrafish is a complex process involving the precise regulation of multiple signaling pathways, but this...
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Linking unfolded protein response to ovarian cancer cell fusion
BackgroundPolyploid giant cancer cells (PGCCs) have been observed in epithelial ovarian tumors. They can resist antimitotic drugs, thus participating...
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Reactive Oxygen Species in Oral Squamous Cell Carcinoma Progression and Importance of Stem Cells in Cancer Therapeutics
Oral squamous cell carcinoma is the most frequent oral malignancy worldwide classified under the head and neck cancer category. Reactive oxygen...
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Reactive Oxygen Species in Oral Squamous Cell Carcinoma Progression and Importance of Stem Cells in Cancer Therapeutics
Oral squamous cell carcinoma is the most frequent oral malignancy worldwide classified under the head and neck cancer category. Reactive oxygen...
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Cell-Mediated Neurorestorative Mechanisms Underpinning Beneficial Effects in Ischemic Stroke
Stroke is the most common cause of death and disability throughout the world. The development of promising stem cell-based interventions with the...